{"id":206,"date":"2025-06-18T03:38:13","date_gmt":"2025-06-17T19:38:13","guid":{"rendered":"http:\/\/www.leishidiet.com\/?p=206"},"modified":"2025-06-19T02:44:06","modified_gmt":"2025-06-18T18:44:06","slug":"%e5%9f%ba%e5%9b%a0%e6%95%b2%e9%99%a4%e5%b0%8f%e9%bc%a0%e7%9b%b8%e5%85%b3%e8%a1%80%e7%ae%a1%e9%92%99%e5%8c%96%e6%a8%a1%e5%9e%8b","status":"publish","type":"post","link":"https:\/\/www.leishidiet.com\/?p=206","title":{"rendered":"\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u76f8\u5173\u8840\u7ba1\u9499\u5316\u6a21\u578b"},"content":{"rendered":"\n

\u57fa\u56e0\u6572\u9664\u5c0f\u9f20<\/a>\u8840\u7ba1\u9499\u5316\u6a21\u578b<\/a>\u662f\u5229\u7528\u8f6c\u57fa\u56e0\u6280\u672f\uff0c\u628a\u5bf9\u8840\u7ba1\u9499\u5316\u6709\u6291\u5236\u4f5c\u7528\u7684\u57fa\u56e0\u7f3a\u5931\u6216\u66ff\u6362\u4ee5\u5236\u5907\u8840\u7ba1\u9499\u5316\u7684\u5c0f\u9f20\u6a21\u578b\u3002\u8fd9\u79cd\u65b9\u6cd5\u6392\u9664\u4e86\u996e\u98df\u548c\u836f\u7269\u8bf1\u5bfc\u8840\u7ba1\u9499\u5316\u65f6\u6240\u4f34\u968f\u7684\u526f\u4f5c\u7528\u548c\u590d\u5408\u56e0\u7d20\uff0c\u4f46\u662f\u5176\u5236\u5907\u8fc7\u7a0b\u590d\u6742\uff0c\u9700\u65f6\u957f\uff0c\u6210\u672c\u8f83\u9ad8\u3002<\/p>\n\n\n\n

\u57fa\u8d28Gla\u86cb\u767d\u7f3a\u9677\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u57fa\u8d28Gla\u86cb\u767d(MGP)\u662f\u4e00\u79cd\u753184\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u7ec4\u6210\u7684\u5206\u5b50\u91cf\u4e3a14kDa\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u86cb\u767d\uff0c\u4e3b\u8981\u5728\u80be\u810f\u3001\u5fc3\u810f\u3001\u8f6f\u9aa8\u3001VSMC\u3001\u5185\u76ae\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7b49\u90e8\u4f4d\u8868\u8fbe\u3002<\/p>\n\n\n\n

\u5728\u8f85\u52a9\u56e0\u5b50\u7ef4\u751f\u7d20K1\u7684\u5b58\u5728\u4e0b\uff0c\u03b3-\u8c37\u6c28\u9178\u7fa7\u5316\u9176\u53ef\u5c06\u65e0\u6d3b\u6027\u7684\u8c37\u6c28\u9178\u6b8b\u57fa\u7fa7\u5316\u4e3a\u6709\u6d3b\u6027\u7684Gla\u6b8b\u57fa\uff0c\u5177\u67095\u4e2aGla\u6b8b\u57fa\u7684MGP\u4e0e\u7f9f\u57fa\u78f7\u7070\u77f3\u5177\u6709\u9ad8\u5ea6\u4eb2\u548c\u529b\uff0c\u53ef\u6291\u5236\u9499\u6c89\u79ef\u53ca\u7f9f\u57fa\u78f7\u7070\u77f3\u6676\u4f53\u589e\u957f\u4ece\u800c\u6291\u5236\u8840\u7ba1\u9499\u5316\u3002<\/p>\n\n\n\n

Robicsek\u7b49\u53d1\u73b0MGP\u5c0f\u9f20\u53ef\u4ea7\u751f\u5e7f\u6cdb\u7684\u52a8\u8109\u5f39\u529b\u5c42\u9499\u5316\uff0c\u5305\u62ec\u4e3b\u52a8\u8109\u53ca\u5176\u5927\u7684\u5206\u652f\u3001\u6240\u6709\u5f39\u6027\u52a8\u8109\u548c\u808c\u8089\u52a8\u8109\uff0c\u540c\u65f6\u51a0\u72b6\u52a8\u8109\u5185\u5f39\u529b\u5c42\u548c\u6c14\u7ba1\u3001\u5c0f\u652f\u6c14\u7ba1\u8f6f\u9aa8\u9499\u5316\uff0c\u4f34\u968f\u4e3b\u52a8\u8109\u7684\u8f6f\u9aa8\u6027\u5316\u751f\uff0c\u8868\u73b0\u4e3a\u8f6f\u9aa8\u6027\u57fa\u8d28\u2161\u578b\u80f6\u539f\u86cb\u767d\u805a\u7cd6\u7684\u51fa\u73b0\u3002<\/p>\n\n\n\n

\u52a8\u8109\u7684\u7ba1\u58c1\u50f5\u786c\uff0c\u8106\u6027\u589e\u5927\uff0c\u6613\u4e8e\u7834\u88c2\u3002\u8be5\u6a21\u578b\u5c0f\u9f20\u51fa\u751f\u540e1\u5468\u51fa\u73b0\u52a8\u8109\u4e2d\u819c\u9499\u5316\uff0c\u4e24\u5468\u65f6\u53d8\u5316\u660e\u663e\uff0c3\u5468\u65f6\u4e2d\u819c\u5168\u90e8\u9499\u5316\uff0c\u4e24\u4e2a\u6708\u65f6\u5e38\u56e0\u4e3b\u52a8\u8109\u7834\u88c2\u6b7b\u4ea1\u3002<\/p>\n\n\n\n

\u5176\u673a\u5236\u53ef\u80fd\u662fMGP\u4e0e\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d2(bone morphogenetic proteins 2\uff0cBMP-2)\u76f8\u7ed3\u5408\u963b\u65ad\u4e86BMP-2\u7684\u4f5c\u7528\uff0c\u800cMGP\u5c0f\u9f20\u4e0d\u80fd\u6291\u5236BMP-2\u7684\u6210\u9aa8\u6d3b\u6027\u800c\u5bfc\u81f4\u8840\u7ba1\u9499\u5316\u7684\u53d1\u751f\u3002<\/p>\n\n\n\n

\u8fd1\u6765\u7814\u7a76\u8fd8\u8bc1\u5b9e\uff0c\u8109\u7ba1\u7cfb\u7edf\u4e2dMGP\u7ec4\u7ec7\u7279\u5f02\u6027\u6572\u9664\u7684\u5c0f\u9f20\u5982\u679c\u518d\u6062\u590d\u8868\u8fbeMGP\u5219\u53ef\u963b\u6b62\u8840\u7ba1\u9499\u5316\u7684\u53d1\u751f\u3002<\/p>\n\n\n\n

\u9aa8\u4fdd\u62a4\u7d20\u7f3a\u9677\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u9aa8\u4fdd\u62a4\u7d20(oateoprotegerin\uff0cOPG)\u662f\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(tumour necrosis factor\uff0cTNF)\u53d7\u4f53\u57fa\u56e0\u8d85\u5bb6\u65cf\u7684\u6210\u5458\uff0c\u5728\u8f6f\u9aa8\u7ec4\u7ec7\u53ca\u52a8\u8109\u4e2d\u5747\u6709\u8868\u8fbe\uff0c\u662f\u4e00\u79cd\u80fd\u5728\u4f53\u5185\u5916\u6291\u5236\u7834\u9aa8\u7ec6\u80de\u53d1\u80b2\u7684\u5206\u6ccc\u6027\u86cb\u767d\u3002<\/p>\n\n\n\n

\u751f\u7406\u72b6\u6001\u4e0b\u4ea7\u751f\u7684OPG\u8fd8\u80fd\u7ef4\u6301\u5185\u76ae\u7ec6\u80de\u7684\u751f\u5b58\uff0c\u964d\u4f4e\u8840\u7ba1\u5bf9\u9aa8\u8d28\u7684\u91cd\u5438\u6536\u3002<\/p>\n\n\n\n

Bucay\u7b49\u5236\u5907\u7684OPG\u5c0f\u9f20\u51fa\u73b0\u603b\u7684\u9aa8\u5bc6\u5ea6\u7684\u4e0b\u964d\u548c\u9aa8\u6298\u53d1\u751f\u7387\u7684\u5347\u9ad8\uff0c\u540c\u65f6\u4ea7\u751f\u52a8\u8109\u5185\u819c\u548c\u4e2d\u819c\u7684\u9499\u5316\uff0c\u5728\u4e24\u5468\u65f6\u51fa\u73b0\uff0c\u4e24\u4e2a\u6708\u65f6\u6700\u4e3a\u660e\u663e\uff0c\u4f46\u6ca1\u6709MGP\u5c0f\u9f20\u52a8\u8109\u9499\u5316\u8303\u56f4\u5e7f\u6cdb\uff0c\u9499\u5316\u4e3b\u8981\u53d1\u751f\u5728\u4e3b\u52a8\u8109\u548c\u80be\u52a8\u8109\uff0c\u5728\u5c0f\u52a8\u8109\u4e2d\u4e0d\u660e\u663e\uff0c\u4f34\u6709\u4e25\u91cd\u7684\u9aa8\u8d28\u758f\u677e\uff0c\u5176\u75c5\u53d8\u8fd8\u53ef\u4ee5\u5728\u5185\u6e90\u6027OPG\u4ea7\u751f\u7684\u90e8\u4f4d\u51fa\u73b0\u3002<\/p>\n\n\n\n

\u7531\u4e8eOPG\u80fd\u901a\u8fc7\u6838\u56e0\u5b50KB\u4fe1\u53f7\u9014\u5f84\u7ade\u4e89\u6027\u6291\u5236\u9aa8\u4fdd\u62a4\u7d20\u914d\u4f53\uff0cOPG\u7684\u7f3a\u5931\u4f7f\u5176\u6291\u5236\u9aa8\u4fdd\u62a4\u7d20\u914d\u4f53\u7684\u4f5c\u7528\u6d88\u5931\u800c\u4ea7\u751f\u8840\u7ba1\u9499\u5316\u3002Orita\u7b49\u526f\u6700\u65b0\u53d1\u73b0\uff0c6\uff5e10\u5468\u9f84\u7684\u96c4\u6027OPG\u5c0f\u9f20\u8fde\u7eed3d\u6ce8\u5c04\u7ef4\u751f\u7d20D3\u540e\u53ef\u89c1\u4e3b\u52a8\u8109\u4e2d\u819cVSMC\u80de\u6d46\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u4e2d\u4e25\u91cd\u7684\u9499\u6c89\u79ef\uff0c\u78b1\u6027\u78f7\u9178\u9176(alkaline phosphatase\uff0cALP)\u7684\u6d3b\u6027\u4e0e\u4e3b\u52a8\u8109\u9499\u5316\u9762\u79ef\u5448\u6b63\u76f8\u5173\uff0c\u4f46\u65e0VSMC\u51cb\u4ea1\u548c\u5de8\u566c\u7ec6\u80de\u6d78\u6da6\u3002<\/p>\n\n\n\n

\u8f7d\u8102\u86cb\u767dE\u7f3a\u9677\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u8f7d\u8102\u86cb\u767dE(apolipoprotein E\uff0cApoE)\u5206\u5e03\u4e8e\u4e73\u7cdc\u5fae\u7c92(carrier protein\uff0cCM)\u3001\u6781\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d(very low density lipoprotein\uff0cVLDL)\u548c\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d(high density lipoprotein\uff0cHDL)\u4e2d\uff0c\u80fd\u8bc6\u522b\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53(low density lipoprotein  receptor\uff0cLDLR)\uff0c\u7ed3\u5408\u548c\u8f6c\u8fd0\u8102\u8d28\u3001\u7a33\u5b9a\u8102\u86cb\u767d\u7ed3\u6784\u800c\u53c2\u4e0e\u8102\u86cb\u767d\u4ee3\u8c22\u3002<\/p>\n\n\n\n

\u8f7d\u8102\u86cb\u767dE\u5c0f\u9f20\u5728\u4e0a\u4e16\u7eaa90\u5e74\u4ee3\u521d\u671f\u5373\u5e7f\u6cdb\u7528\u4e8e\u7814\u7a76\u9ad8\u80c6\u56fa\u9187<\/a>\u8840\u75c7\u548cAs\u7684\u6591\u5757\u8fdb\u5c55\u3002Qiao\u7b49\u7814\u7a76\u53d1\u73b0\u8f7d\u8102\u86cb\u767dE\u5c0f\u9f20\u5728As\u7ea4\u7ef4\u5e3d\u5f62\u6210\u540e\u5373\u53ef\u4ea7\u751f\u8840\u7ba1\u9499\u5316\uff0c2\/3\u7684\u8f7d\u8102\u86cb\u767dE\u5c0f\u9f20\u5728\u6b63\u5e38\u996e\u98df\u4e0b\u540c\u65f6\u53d1\u751f\u4e3b\u52a8\u8109\u548c\u51a0\u72b6\u52a8\u8109\u7684\u9499\u5316\u3002<\/p>\n\n\n\n

\u5728\u9ad8\u8102\u9972\u6599<\/a>\u8f85\u52a9\u4e0b\u8f7d\u8102\u86cb\u767dE\u5c0f\u9f20\u53ef\u51fa\u73b0\u66f4\u4e3a\u5e7f\u6cdb\u7684As\u548c\u8840\u7ba1\u9499\u5316\u3002\u8be5\u6a21\u578b\u5e7f\u6cdb\u7528\u4e8e\u7814\u7a76\u52a8\u8109\u7ca5\u6837\u786c\u5316\u548c\u8840\u7ba1\u9499\u5316\u7684\u53d1\u75c5\u548c\u6cbb\u7597\u3002<\/p>\n\n\n\n

Massy\u7b49\u53d1\u73b0\u8f7d\u8102\u86cb\u767dE\u5c0f\u9f20\u5728\u6162\u6027\u80be\u529f\u80fd\u8870\u7aed\u540e\u671f\u51fa\u73b0\u7684\u5c3f\u6bd2\u75c7\u75c7\u72b6\u80fd\u52a0\u901f\u8f7d\u8102\u86cb\u767d\u5185\u819c\u4ee5\u53ca\u65e0\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u8840\u7ba1\u4e2d\u819c\u7684\u9499\u5316\u5f62\u6210\u3002<\/p>\n\n\n\n

\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u7f3a\u9677\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u5e7f\u6cdb\u5206\u5e03\u4e8e\u809d\u810f\u548c\u52a8\u8109\u58c1\u7ec6\u80de\u7684\u7ec6\u80de\u819c\u8868\u9762\uff0c\u80fd\u7279\u5f02\u6027\u8bc6\u522b\u5e76\u7ed3\u5408LDL\uff0c\u5176\u4e3b\u8981\u4f5c\u7528\u662f\u8f6c\u8fd0\u809d\u810f\u5408\u6210\u7684\u5185\u6e90\u6027\u80c6\u56fa\u9187\uff0cLDLR\u7f3a\u9677\u662f\u5f15\u8d77\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u7684\u91cd\u8981\u539f\u56e0\u3002<\/p>\n\n\n\n

Towler\u7b49\u7528\u666e\u901a\u996e\u98df\u5582\u517bLDLR\u5c0f\u9f20\u5e76\u4e0d\u80fd\u8bf1\u5bfc\u4ea7\u751f\u80a5\u80d6\u3001\u7cd6\u5c3f\u75c5\u3001AS\u548c\u8840\u7ba1\u9499\u5316\uff0c\u800c\u7ed9\u4e888-10\u5468\u9f84LDLR\u5c0f\u9f20\u5582\u517b\u5bfc\u81f4\u7cd6\u5c3f\u75c5\u7684\u9ad8\u8102\u9ad8\u80c6\u56fa\u9187\u9972\u6599(\u542b1.25\uff05\u7684\u80c6\u56fa\u9187\u548c0.5\uff05\u7684\u80c6\u76d0)\uff0c\u5219\u80fd\u4ea7\u751f\u660e\u663e\u7684\u4e3b\u52a8\u8109\u9499\u5316\uff0c\u8868\u73b0\u4e3a\u4fc3\u8fdb\u77ff\u5316\u548c\u6210\u9aa8\u5206\u5316\u7684\u540c\u6e90\u7ed3\u6784\u57df\u8f6c\u5f55\u56e0\u5b50Msx2\u3001Msx1\u4ee5\u53ca\u6210\u9aa8\u7ec6\u80de\u7684\u57fa\u8d28\u86cb\u767d-\u9aa8\u6865\u86cb\u767d(osteopontin\uff0cOPN)\u7684\u8868\u8fbe\u4e0a\u8c03\uff0cvon Kossa\u67d3\u8272\u8bc1\u660e\u4e3b\u52a8\u8109\u548c\u52a8\u8109\u5916\u7ec4\u7ec7\u4e2d\u5e7f\u6cdb\u9499\u6c89\u79ef\uff0c\u8868\u660e\u5bfc\u81f4\u7cd6\u5c3f\u75c5\u7684\u996e\u98df\u8bf1\u5bfcLDLR\u5c0f\u9f20\u8840\u7ba1\u9499\u5316\u662f\u901a\u8fc7\u542f\u52a8\u6210\u9aa8\u7ec6\u80de\u8f6c\u5f55\u8c03\u8282\u8fc7\u7a0b\u6765\u5b9e\u73b0\u7684\u3002<\/p>\n\n\n\n

\u9aa8\u6865\u86cb\u767d\u7f3a\u9677\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u9aa8\u6865\u86cb\u767d(OPN)\u662f\u4e00\u79cd\u5206\u6ccc\u578b\u7cd6\u57fa\u5316\u78f7\u9178\u86cb\u767d\uff0c\u5728\u9aa8\u3001\u8f6f\u9aa8\u3001\u80be\u3001\u8715\u819c\u548c\u80ce\u76d8\u7b49\u7ec4\u7ec7\u4e2d\u5e7f\u6cdb\u8868\u8fbe\uff0cOPN\u80fd\u4e0e\u5b58\u5728\u4e8e\u7834\u9aa8\u7ec6\u80de\u8868\u9762\u7684\u6574\u5408\u7d20\u03b1v\u03b23\u53d7\u4f53\u7ed3\u5408\uff0c\u9178\u5316\u5c40\u90e8\u7684\u5fae\u73af\u5883\uff0c\u4f7f\u77ff\u7269\u8d28\u6eb6\u89e3\uff0c\u6291\u5236\u7f9f\u57fa\u78f7\u7070\u77f3\u7ed3\u6676\u7684\u751f\u957f\uff0c\u5e76\u5206\u6ccc\u86cb\u767d\u9176\u548c\u6c34\u89e3\u9176\uff0c\u964d\u89e3\u80f6\u539f\u548c\u5176\u5b83\u7684\u9aa8\u57fa\u8d28\u86cb\u767d\uff0c\u523a\u6fc0\u7834\u9aa8\u7ec6\u80de\u7684\u9aa8\u91cd\u5438\u6536\u6d3b\u6027\u3002<\/p>\n\n\n\n

OPN\u6291\u5236\u8840\u7ba1\u9499\u5316\u7684\u4f5c\u7528\u53ef\u80fd\u662f\u901a\u8fc7\u5176\u8f6c\u5f55\u540e\u78f7\u9178\u5316\u4fee\u9970\u6765\u5b9e\u73b0\u7684\uff0c\u672a\u78f7\u9178\u5316\u7684OPN\u5219\u65e0\u6b64\u4f5c\u7528\u3002<\/p>\n\n\n\n

Speer MY\u7b49\u7814\u7a76\u53d1\u73b0OPN\u5c0f\u9f20\u7834\u9aa8\u7ec6\u80de\u529f\u80fd\u5f02\u5e38\uff0c\u5bfc\u81f4\u9aa8\u8d28\u7684\u4e22\u5931\uff0c\u4f46\u662f\u8840\u7ba1\u9499\u5316\u7684\u53d1\u751f\u4e0d\u660e\u663e\u3002\u7136\u800cMGP\u548cOPN\u57fa\u56e0\u53cc\u6572\u9664\u7684\u5c0f\u9f20\u57284\u6708\u9f84\u65f6\u52a8\u8109\u9499\u5316\u7684\u7a0b\u5ea6\u6bd4\u5355\u7eafMGP\u5c0f\u9f20\u66f4\u4e3a\u4e25\u91cd\uff0c\u7ec4\u7ec7\u5b66\u68c0\u67e5\u53d1\u73b0\u52a8\u8109\u5f39\u529b\u5c42\u65ad\u88c2\u3001\u8840\u7ba1\u7834\u88c2\u5e76\u5f62\u6210\u52a8\u8109\u7624\uff0c\u540c\u65f6\u53d1\u73b0\u8fd9\u79cd\u53cc\u6572\u5c0f\u9f20\u7684VSMCs\u7684\u6807\u5fd7\u7269\u03b2-actin\u4e27\u5931\uff0c\u81f4\u4f7fVSMC\u7684\u53ef\u5851\u6027\u4e0b\u964d\u5e76\u8f6c\u5316\u4e3a\u6210\u9aa8\u6837\u7ec6\u80de\u6700\u7ec8\u5bfc\u81f4\u8840\u7ba1\u9499\u5316\u7684\u53d1\u751f\u3002\u4ece\u4e3b\u52a8\u8109\u7684von-Kossa\u5207\u7247\u67d3\u8272\u548c\u9499\u5316\u533a\u57df\u7684\u5b9a\u91cf\u5206\u6790\u8868\u660e\uff0c60\u5468\u9f84OPN\u8f7d\u8102\u86cb\u767dE\u5c0f\u9f20\u6bd460\u5468\u9f84\u8f7d\u8102\u86cb\u767dE\u5c0f\u9f20\u5177\u6709\u66f4\u5e7f\u6cdb\u7684\u9499\u5316\u9762\u79ef\u3002<\/p>\n\n\n\n

\u80ce\u7403\u86cb\u767dA\u7f3a\u9677\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u80ce\u7403\u86cb\u767dA(Fetuin-A)\u53c8\u79f0\u03b12-Heremans-Schmid\u7cd6\u86cb\u767d\uff0c\u662f\u4e00\u79cd\u4e0e\u77ff\u7269\u8d28\u5177\u6709\u9ad8\u5ea6\u4eb2\u548c\u529b\u7684\u8840\u6e05\u86cb\u767d\uff0c\u662f\u7f9f\u57fa\u78f7\u7070\u77f3\u524d\u4f53\u6c89\u79ef\u7684\u6291\u5236\u56e0\u5b50\uff0c\u5b83\u53ef\u4f5c\u4e3a\u8c03\u7406\u7d20\u4fc3\u8fdb\u7ec6\u80de\u5bf9\u7ec6\u80de\u5916\u4e0d\u6eb6\u6027\u9499\u7684\u5185\u541e\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u7528\u7535\u5b50\u663e\u5fae\u955c\u548c\u52a8\u6001\u5149\u6563\u5c04\u5b9e\u9a8c\u89c2\u5bdf\u53d1\u73b0\uff0cFetuin-A\u80fd\u591f\u4e0e\u9499\u548c\u78f7\u5f62\u6210\u76f4\u5f84\u4e3a30\uff5e150nm\u7684\u80f6\u8d28\u72b6\u53ef\u6eb6\u6027\u590d\u5408\u7269\u4ece\u800c\u6291\u5236\u7f9f\u57fa\u78f7\u7070\u77f3\u7ed3\u6676\u7684\u8d77\u59cb\u548c\u521d\u671f\u5408\u6210\uff0c\u4f46\u662f\u5bf9\u5df2\u7ecf\u5f62\u6210\u7684\u7ed3\u6676\u4f53\u65e0\u4f5c\u7528\u3002<\/p>\n\n\n\n

Schafer C\u7b49\u7528\u542b\u7ef4\u751f\u7d20D3\u7684\u9ad8\u9499\u9ad8\u78f7\u996e\u98df\u5582\u517bFetuin-A\u3002\u5c0f\u9f20\u53ef\u81ea\u53d1\u6027\u5730\u4ea7\u751f\u4e25\u91cd\u7684\u5c0f\u8840\u7ba1\u3001\u80be\u5c0f\u7ba1\u548c\u80ba\u6ce1\u7684\u5f02\u4f4d\u9499\u5316\uff0c\u800c\u6709\u9499\u5316\u503e\u5411\u7684DBA\/2\u5c0f\u9f20\u7684Fetuin-A\u7f3a\u5931\u5219\u51fa\u73b0\u4e25\u91cd\u7684\u80be\u3001\u5fc3\u3001\u80ba\u3001\u76ae\u80a4\u5e7f\u6cdb\u7684\u77ff\u7269\u8d28\u7684\u6c89\u79ef\uff0c\u4f34\u6709\u52a8\u8109\u8840\u538b\u7684\u589e\u9ad8\u3001\u80be\u529f\u80fd\u8870\u7aed\u3001\u4e25\u91cd\u7684\u86cb\u767d\u5c3f\u3001\u7ee7\u53d1\u6027\u7532\u72b6\u65c1\u817a\u529f\u80fd\u4ea2\u8fdb\u75c7\u548c\u9aa8\u8d28\u7684\u51cf\u5c11\uff0c\u4f46\u672a\u89c1\u5927\u52a8\u8109\u7684\u9499\u5316\u3002\u8fd9\u53ef\u80fd\u4e0eFetuin-A  DBM2\u5c0f\u9f20\u52a8\u8109\u58c1\u4e2d\u6291\u5236\u8840\u7ba1\u9499\u5316\u7684\u56e0\u5b50MGP\u3001OPN\u7684mRNA\u548c\u86cb\u767d\u6c34\u5e73\u7684\u4e0a\u5347\u6709\u5173\u3002<\/p>\n\n\n\n

Klotho\u57fa\u56e0\u7f3a\u9677\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

Klotho\u57fa\u56e0\u662fKuro-o M\u7b49\u4e8e1997\u5e74\u53d1\u73b0\u7684\u80fd\u591f\u6291\u5236\u8870\u8001\u7684\u65b0\u57fa\u56e0\uff0c\u7f16\u7801\u4e0e\u03b2-\u8461\u8404\u7cd6\u82f7\u9176\u5e8f\u5217\u76f8\u4f3c\u7684\u4e00\u79cd\u819c\u86cb\u767d\uff0c\u5927\u90e8\u5206\u5728\u80be\u810f\u548c\u8111\u7ec4\u7ec7\u8868\u8fbe\u3002<\/p>\n\n\n\n

Kuro-o\u7b49\u901a\u8fc7\u63d2\u5165\u7a81\u53d8\u57f9\u80b2\u6210Klotho\u5c0f\u9f20\uff0c\u51fa\u73b0\u4e0e\u4eba\u7c7b\u76f8\u4f3c\u7684\u4ee5\u5bff\u547d\u7f29\u77ed\u4e3a\u7279\u5f81\u7684\u8870\u8001\u8fc7\u7a0b\uff0c\u5305\u62ec\u52a8\u8109\u786c\u5316\u3001\u4e0d\u5b55\u3001\u76ae\u80a4\u840e\u7f29\u3001\u9aa8\u8d28\u758f\u677e\u548c\u80ba\u6c14\u80bf\uff0cKlotho\u5c0f\u9f20\u4e8e\u51fa\u751f\u540e4\u5468\u5c31\u80fd\u4ea7\u751f\u8fdb\u884c\u6027\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8fc7\u7a0b\uff0c\u968f\u540e\u51fa\u73b0\u4e2d\u7b49\u5927\u5c0f\u7684\u808c\u6027\u52a8\u8109\u7684\u4e2d\u819c\u9499\u5316\u53ca\u5176\u5185\u819c\u589e\u539a\uff0c\u80be\u810f\u7684\u5c0f\u52a8\u8109\u4e5f\u51fa\u73b0\u5e7f\u6cdb\u7684\u9499\u5316\u3002<\/p>\n\n\n\n

Koh N\u7b49\u7684\u7814\u7a76\u53d1\u73b0\uff0cKlotho\u57fa\u56e0\u7684\u7f3a\u5931\u4e0e\u6162\u6027\u80be\u529f\u80fd\u8870\u7aed\u75c5\u4eba\u6240\u51fa\u73b0\u7684\u9ad8\u78f7\u8840\u75c7\u548c\u80be\u75c5\u6027\u9aa8\u8425\u517b\u4e0d\u826f\u6709\u5173\u3002\u5c3f\u6bd2\u75c7\u671f\u7684\u75c5\u4eba\u51fa\u73b0\u8870\u8001\u3001\u52a8\u8109\u786c\u5316\u7684\u52a0\u901f\u548c\u5f02\u4f4d\u9499\u5316\u7b49\u75c7\u72b6\uff0c\u4e0eKlotho\u86cb\u767d\u4ea7\u751f\u51cf\u5c11\u800c\u5931\u53bb\u5176\u4fdd\u62a4\u4f5c\u7528\u6709\u5173<\/p>\n\n\n\n

Smad6\u57fa\u56e0\u7f3a\u9677\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

Smad\u662f\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2(transforming growth factor\uff0cTGF-\u03b2)\/\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d(Bone morphogenic protein\uff0cBMP)\u5bb6\u65cf\u4fe1\u53f7\u86cb\u767d\uff0c\u5305\u62ec8\u4e2a\u6210\u5458\uff0c\u5206\u522b\u79f0\u4e3aSmad1\uff5e8\u3002<\/p>\n\n\n\n

\u5206\u4e3a\u4e09\u7c7b\uff1aSmadl\u30012\u30013\u30015\u548c8\u79f0\u4e3a\u53d7\u4f53\u8c03\u8282Smad\uff0c\u4ecb\u5bfcTGF-\u03b2\u8d85\u5bb6\u65cf\u7684\u4fe1\u53f7\uff1bSmad6\u548c7\u79f0\u4e3a\u6291\u5236\u6027Smad\uff0c\u6291\u5236TGF-\u03b2\u8d85\u5bb6\u65cf\u4fe1\u53f7\u7684\u4f20\u5bfc\uff1bSmad4\u4e3a\u534f\u540cSmad\uff0c\u662f\u53d7\u4f53\u8c03\u8282Smad\u7684\u534f\u52a9\u4fe1\u53f7\u86cb\u767d\u3002<\/p>\n\n\n\n

Hruska KA\u7b49\u7814\u7a76\u8868\u660eBMP2\/4\u80fd\u901a\u8fc7\u6fc0\u6d3b\u5176\u4e0b\u6e38\u7684Smad1\/5\u8c03\u63a7\u6210\u9aa8\u7ec6\u80de\u7684\u5206\u5316\u548c\u4fc3\u8fdb\u6210\u9aa8\u7684\u4f5c\u7528\uff0c\u800cSmad6\u5219\u901a\u8fc7\u6291\u5236Smad1\/5\u7684\u6d3b\u6027\u800c\u6291\u5236\u6240\u6709BMP\u8bf1\u5bfc\u8840\u7ba1\u9499\u5316\u7684\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def\uff1b\u6b64\u5916Smad6\u8fd8\u80fd\u901a\u8fc7\u4e0eBMP \u2160\u578b\u53d7\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u62ee\u6297BMP\u8bf1\u5bfc\u7684\u6210\u9aa8\u4f5c\u7528\u3002<\/p>\n\n\n\n

Smad6 \u5c0f\u9f20\u5fc3\u74e3\u819c\u5f62\u6210\u969c\u788d\uff0c6\u5468\u65f6\u5fc3\u810f\u9644\u8fd1\u7684\u4e3b\u52a8\u8109\u548c\u80ba\u52a8\u8109\u51fa\u73b0\u9499\u5316\uff0c\u800c\u4e14\u5728\u4e3b\u52a8\u8109\u7684\u4e2d\u819c\u53d1\u73b0\u8f6f\u9aa8\u7684\u5316\u751f\u548c\u9aa8\u5c0f\u6881\u7ed3\u6784\u7684\u5f62\u6210\uff0c\u53ef\u4f34\u6709\u9aa8\u9ad3\u7684\u6210\u5206\uff0c\u4e0eBMP-2\u4ecb\u5bfc\u7684\u8f6f\u9aa8\u5185\u6210\u9aa8\u8fc7\u7a0b\u76f8\u4f3c\uff0e\u4f46\u662f\u6709Smad6\u8868\u8fbe\u7684VSMC\u5904\u7684\u9aa8\u5f62\u6210\u53d7\u5230\u6291\u5236\u3002\u540c\u65f6\u5185\u76ae\u4f9d\u8d56\u7684\u8840\u7ba1\u8212\u5f20\u529f\u80fd\u4e0b\u964d\uff0c\u80a1\u52a8\u8109\u7684\u5e73\u5747\u52a8\u8109\u538b\u5347\u9ad8\u3002<\/p>\n\n\n\n

\u78b3\u9178\u82f7\u9176\u540c\u529f\u9176\u2161(carbonic anhydrase\u2161\uff0cCA\u2161)\u7f3a\u9677(CA\u2161)\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u78b3\u9178\u82f7\u9176(carbonic anhydrase\uff0cCA)\u80fd\u628a\u4e8c\u6c27\u5316\u78b3(Co2)\u548c\u6c34\u8f6c\u5316\u6210\u78b3\u9178\u6c22\u6839\u548c\u6c22\u79bb\u5b50\uff0c\u901a\u8fc7\u7ec6\u80de\u819c\u4e0a\u7684\u94a0\u6c22\u4ea4\u6362\u4f7f\u6c22\u5206\u6ccc\u5230\u7ec6\u80de\u5916\uff0c\u4ece\u800c\u8c03\u8282\u4e8c\u6c27\u5316\u78b3\u8f6c\u8fd0\u3001pH\u7a33\u6001\u3001\u9aa8\u7684\u91cd\u5438\u6536\u548c\u5c3f\u7d20\u7684\u751f\u6210\u7b49\u3002<\/p>\n\n\n\n

Whyte\u7b49\u53d1\u73b0CA\u2161\u662f\u78b3\u9178\u82f7\u9176\u5bb6\u7cfb\u7684\u50ac\u5316\u6d3b\u6027\u6700\u5f3a\u7684\u540c\u529f\u9176\uff0c\u5e7f\u6cdb\u5206\u5e03\u4e8e\u54fa\u4e73\u52a8\u7269\u7684\u9aa8\u3001\u80be\u3001\u8111\u7b49\u5404\u7ec4\u7ec7\u7ec6\u80de\u53ca\u7ea2\u7ec6\u80de\u80de\u6d46\u5185\uff0c\u5c24\u4ee5\u7834\u9aa8\u7ec6\u80de\u4e2d\u542b\u91cf\u6700\u4e30\u5bcc\u3002\u9057\u4f20\u5b66\u7814\u7a76\u8868\u660e\uff0cCA\u2161\u7f3a\u9677\u662f\u4e00\u79cd\u5e38\u67d3\u8272\u4f53\u9690\u6027\u9057\u4f20\u75c5\uff0c\u4e34\u5e8a\u8868\u73b0\u4e3a\u9aa8\u786c\u5316\u75c7\u3001\u80be\u5c0f\u7ba1\u6027\u9178\u4e2d\u6bd2\u4ee5\u53ca\u5927\u8111\u7684\u9499\u5316\u3002\u7531\u4e8e\u9aa8\u7684\u91cd\u5438\u6536\u9700\u8981\u9178\u6027\u7684\u5fae\u73af\u5883\uff0c\u800c\u7834\u9aa8\u7ec6\u80de\u4e2d\u78b3\u9178\u82f7\u9176\u540c\u529f\u9176\u2161\u7f3a\u9677\u540e\uff0c\u4e27\u5931\u5f62\u6210\u6c22\u79bb\u5b50\u7684\u80fd\u529b\uff0c\u5931\u53bb\u4e86\u9aa8\u91cd\u5438\u6536\u6240\u9700\u7684\u9178\u6027\u5fae\u73af\u5883\uff0c\u56e0\u6b64CA\u2161\u5c0f\u9f20\u51fa\u73b0\u9aa8\u786c\u5316\u75c7\u548c\u8840\u7ba1\u9499\u5316\u3002<\/p>\n\n\n\n

Spicer\u7b49\u89c2\u5bdf\u5230CA\u2161\u4e00\u5c0f\u9f20\u5927\u90e8\u5206\u5668\u5b98\u7684\u5c0f\u52a8\u8109\u53ca\u5176\u5206\u652f\u7684\u4e2d\u819c\u5747\u53d1\u751f\u9499\u5316\uff0c\u8fd9\u79cd\u8840\u7ba1\u9499\u5316\u4e0e\u5e74\u9f84\u7684\u589e\u957f\u5448\u6b63\u76f8\u5173\uff0c\u96c4\u6027\u6bd4\u96cc\u6027\u4e25\u91cd\uff0c\u751f\u6b96\u9053\u52a8\u8109\u58c1\u6709\u5e7f\u6cdb\u7684\u9499\u76d0\u6c89\u79ef\u3002<\/p>\n\n\n\n

\u539f\u7ea4\u7ef4\u86cb\u767d1\u7f3a\u9677\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

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