{"id":189,"date":"2025-06-18T03:16:08","date_gmt":"2025-06-17T19:16:08","guid":{"rendered":"http:\/\/www.leishidiet.com\/?p=189"},"modified":"2025-08-27T21:16:07","modified_gmt":"2025-08-27T13:16:07","slug":"%e5%a4%9a%e5%9b%8a%e5%8d%b5%e5%b7%a2%e7%bb%bc%e5%90%88%e5%be%81%e7%9a%84%e5%b0%8f%e9%bc%a0%e6%a8%a1%e5%9e%8b%e4%bb%8b%e7%bb%8d","status":"publish","type":"post","link":"https:\/\/www.leishidiet.com\/?p=189","title":{"rendered":"\u591a\u56ca\u5375\u5de2\u7efc\u5408\u5f81\u7684\u5c0f\u9f20\u6a21\u578b\u4ecb\u7ecd"},"content":{"rendered":"\n

\u5927 \u3001\u5c0f \u9f20\u751f\u6b96\u5468\u671f\u77ed\u3001\u52a8\u7269\u6613\u4e8e\u64cd\u4f5c \uff0c\u4e14\u57fa\u56e0\u80cc\u666f\u76f8\u5bf9\u7a33\u5b9a \u3002\u540c\u5927\u9f20\u76f8\u6bd4\uff0c\u4e00\u7cfb\u5217\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u548c\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u80fd\u5e2e \u52a9\u9610\u660e\u67d0\u79cd\u57fa\u56e0\u5728 PCOS\u75c5\u7406\u673a\u5236\u4e2d\u7684\u4f5c\u7528 \uff0c\u4ece\u800c\u4e3a PCOS\u7684\u7814\u7a76\u63d0\u4f9b\u6709\u529b\u5de5\u5177\u3002\u56e0\u6b64\u672c\u6587\u5217\u4e3e\u76ee\u524d\u5e38\u7528\u7684 PCOS\u5c0f\u9f20\u6a21\u578b \uff0c\u5e76\u603b\u7ed3\u4e86\u4e0d\u540c\u6a21\u578b\u7684\u751f\u6b96\u4e0e\u4ee3\u8c22\u7279\u5f81 \u3002<\/p>\n\n\n\n

\u4e00 \u3001 \u96c4\u6fc0\u7d20\u8bf1\u5bfc\u7684 PCOS\u5c0f\u9f20\u6a21\u578b<\/strong><\/p>\n\n\n\n

\u9ad8\u96c4\u6fc0\u7d20\u8840\u75c7\u4e0d\u4ec5\u662fPCOS\u60a3\u8005\u6700\u4e3a\u7a81\u51fa\u7684\u7279\u5f81\u4e4b\u4e00 \uff0c\u4e5f\u5728 PCOS\u7684\u53d1\u751f\u53d1\u5c55\u4e2d\u8d77\u7740\u4e2d\u5fc3\u4f5c\u7528 \uff0c\u5f71\u54cd\u4e86\u60a3\u8005\u7684\u751f\u6b96\u548c\u4ee3\u8c22\u8868\u578b\u3002\u81ea 1962\u5e74 Mahesh\u548c Greenblatt\u4ece PCOS\u60a3\u8005\u7684\u5375\u5de2\u4e2d\u5206\u79bb\u51fa\u4e86\u96c4\u6fc0\u7d20\u4ee5\u540e \uff0c\u96c4\u6fc0\u7d20\u5c31\u5f00\u59cb\u7528\u4e8e\u8bf1\u5bfc PCOS\u52a8\u7269\u6a21\u578b\u3002\u96c4\u6fc0\u7d20\u4e3b\u8981\u5305 \u62ec\u4e09\u79cd \uff1a\u777e\u916e (testosterone\uff0cT)\uff0c\u8131 \u6c22\u8868 \u96c4\u916e (dehydroepiandrosterone\uff0cDHEA)\u548c\u53cc\u6c22 \u777e\u916e (dihydrotestosterone\uff0cDHT)\uff0c\u5176\u4e2d\u777e\u916e\u7684\u751f\u7269\u6d3b\u6027\u6700\u5f3a \u3002<\/p>\n\n\n\n

(\u4e00 )\u777e \u916e(testosterone\uff0cT)<\/strong><\/p>\n\n\n\n

\u777e\u916e\u662f\u4e00\u79cd\u4e3b\u8981\u7531\u7537\u6027\u777e\u4e38\u6216\u8005\u5973\u6027\u5375\u5de2\u5206\u6ccc\u7684\u96c4\u6fc0\u7d20\uff0c\u5c11\u91cf\u777e\u916e\u4e5f\u53ef\u7531\u80be\u4e0a\u817a\u7684\u7f51\u72b6\u5e26\u5206\u6ccc\u3002\u5728\u4f53\u5185\u777e\u916e\u4f1a\u76f4\u63a5\u4f5c\u7528\u4e8e\u96c4\u6fc0\u7d20\u53d7\u4f53 \uff0c\u6216\u8005\u5148\u8f6c\u5316\u4e3aDHT\u7136\u540e\u4f5c\u7528\u4e8e\u96c4\u6fc0\u7d20\u53d7\u4f53 \uff0c\u6b64\u5916 \uff0c\u777e\u916e\u4e5f\u80fd\u8f6c\u5316\u6210\u96cc\u4e8c\u9187\u4f5c\u7528\u4e8e\u96cc\u6fc0\u7d20\u53d7\u4f53\u4ece\u800c\u53d1\u6325\u529f\u80fd\u3002<\/p>\n\n\n\n

\u777e\u916e\u8bf1\u5bfc\u7684 PCOS\u6a21\u578b\u4e3b\u8981\u96c6\u4e2d\u5728\u7ef5\u7f8a\u3001\u7334\u5b50\u548c\u5927\u9f20(Demissie\u7b49\uff0e2008)\uff0c\u800c\u4e0d\u5e38\u7528\u4e8e\u5c0f\u9f20\u6a21\u578b \u3002\u5728\u5c0f\u9f20\u4e2d\uff0c\u4ec5\u6709\u62a5\u9053\u5728\u6000\u5b55\u665a\u671f\u6216\u65b0\u751f\u9f20\u9636\u6bb5\u7ed9\u4e88\u777e\u916e\u7684\u7814\u7a76\u3002<\/p>\n\n\n\n

Keisler\u7b49\u53d1\u73b0\u5bf9\u6000\u5b55 l3-18\u5929\u7684 NZB\uff0fW \u6bcd\u9f20\u7ed9\u4e88 0.75\u6beb\u514b\u7684\u777e\u916e\u540e\u5e76\u6ca1\u6709\u5f15\u8d77\u5b50\u4ee3\u5c0f\u9f20\u5375\u5de2\u529f\u80fd\u7684\u7d0a\u4e71 \uff0c\u5c0f\u9f20\u5375\u5de2\u5f62\u6001\u6b63\u5e38\u4e14\u6709\u9ec4\u4f53 (Keisler\u7b49\uff0e1991)\u3002<\/p>\n\n\n\n

Edwards \u7b49 (1971)\u5728\u65b0\u751f Swiss\u5c0f \u9f20\u51fa\u751f\u540e\u7684\u524d\u4e09\u5929\u91cc\u6bcf\u5929\u7ed9\u4e88100\u5fae\u514b\u7684\u777e\u916e\u6216\u8005\u4e19\u9178\u777e\u916e\u53ef\u4ee5\u5bfc\u81f4\u5c0f\u9f20\u4e0d\u6392\u5375 \u3001\u6392\u5375\u7d0a\u4e71\u548c\u5375\u5de2\u591a\u56ca\u5316 (Edwards\u7b49\uff0e1971)\uff0c \u4f46\u8be5\u7814\u7a76\u672a\u68c0\u6d4b\u4ee3\u8c22\u65b9\u9762\u7684\u53d8\u5316\u3002<\/p>\n\n\n\n

\u53e6\u5916 \uff0c\u6709\u7814\u7a76\u663e\u793a\u5bf95\u5929\u5927\u7684\u65b0\u751f\u5c0f\u9f20\u7ed9\u4e881\u6beb\u514b\u9ad8\u5242\u91cf\u7684\u777e\u916e \uff0c \u5c0f\u9f20\u53ef\u4ee5\u5728 9\u5468\u65f6\u8868\u73b0\u51fa\u5375\u5de2\u591a\u56ca\u5316 \u3001\u9ec4\u4f53\u7f3a\u5c11\u548c\u4e0d\u5b55 (Kamijo\u7b49\uff0e1994)\u3002<\/p>\n\n\n\n

\u4ee5\u4e0a\u7684\u65b9\u6cd5\u867d\u7136\u5e76\u4e0d\u90fd\u80fd\u591f\u6210\u529f\u8bf1\u5bfc\u51fa PCOS\u7684\u8868\u578b\uff0c\u4f46\u662f\u65b0\u751f\u5c0f\u9f20\u6ce8\u5c04\u777e\u916e\u540e\u8fd8\u662f\u8868\u73b0\u51fa\u4e86\u4e00 \u4e9b PCOS\u751f\u6b96\u65b9\u9762\u7684\u7279\u5f81 \uff0c \u6bd4\u5982\u4e0d\u6392\u5375\u548c\u5375\u5de2\u591a\u56ca\u5316\u7b49 \uff0c\u4f46 \u7f3a\u5c11\u4ee3\u8c22\u65b9\u9762\u7684\u6570\u636e \u3002<\/p>\n\n\n\n

(\u4e8c )\u8131\u6c22\u8868\u96c4\u916e (dehydroepiandrosterone\uff0c DHEA)<\/strong><\/p>\n\n\n\n

DHEA\u662f\u4e00\u79cd\u4e3b\u8981\u5728\u80be\u4e0a\u817a\u5408\u6210\u7684\u96c4\u6fc0\u7d20 \uff0c\u5927\u90e8\u5206DHEA\u88ab\u786b\u9178\u5316\u4e3a DHEA\u786b\u9178\u76d0 (DHE- AS)\u800c\u91ca\u653e\u5165\u8840 \uff0c\u56e0\u6b64DHEAS\u7684\u6c34\u5e73\u6709\u6548\u5730\u53cd\u6620\u51fa DHEA\u7684\u5408\u6210 \uff0c\u7814\u7a76\u62a5\u9053\u81f3\u5c11 20\uff05 \uff5e30\uff05 PCOS\u60a3\u8005\u8840\u6e05 \u4e2d DHEAS\u7684\u6c34\u5e73\u5347\u9ad8 (Goodarzi\u7b49\uff0e2014)\u3002<\/p>\n\n\n\n

Roy\u7b49 (1962)\u9996\u5148\u5728 22-23\u5929\u9f84\u7684\u5927\u9f20\u4e2d\u6ce8\u5c04 DHEA\uff0c\u8fde\u7eed\u6ce8\u5c04 36\u5929\u540e\u53d1\u73b0 10\u548c 30\u6beb\u514b\uff0f\u516c\u65a4\u4f53 \u91cd\uff0f\u65e5\u7684\u5242\u91cf\u53ef\u5f15\u8d77\u5927\u9f20\u7684\u5375\u5de2\u591a\u56ca\u5316 \u3002<\/p>\n\n\n\n

Motta\u548c\u4ed6\u7684\u540c\u4e8b\u752825\u5929\u9f84\u7684BALB\uff0fc\u5c0f \u9f20 \uff0c\u4ee5\u6bcf\u59296\u6beb\u514b\uff0f 100\u514b(DHEA\uff0f\u4f53\u91cd )\u7684\u5242\u91cf\u8fde\u7eed\u6ce8\u5c0420\u5929\u5f97\u5230 PCOS\u5c0f\u9f20\u6a21\u578b \u3002\u8be5\u6a21\u578b\u5c0f\u9f20\u8868\u73b0\u51fa\u751f\u6b96\u80fd\u529b\u4f4e\u4e0b \u3001\u5375\u5de2\u591a\u56ca\u5316 \uff0c\u540c\u65f6\u5375\u5de2\u4e2d\u95ed\u9501\u5375\u6ce1\u589e\u591a \uff1b\u591a\u56ca\u5316\u5375\u6ce1\u7684\u819c\u7ec6\u80de\u5c42\u53d8\u8584 \uff0c\u9897\u7c92\u7ec6\u80de\u53d8\u7d27\u5bc6 \uff1b\u8840\u6db2\u4e2d\u7684\u96c4\u6fc0\u7d20 \u3001\u96cc\u6fc0\u7d20\u548c\u5b55\u916e\u6c34\u5e73\u5347\u9ad8 \uff0c\u5375\u5de2\u7684\u524d\u5217\u817a\u7d20 E (PGE)\u6c34\u5e73\u964d\u4f4e \u3002\u5c0f \u9f20\u7684\u4f53\u91cd\u548c\u7a7a\u8179\u8840\u7cd6 \u6c34\u5e73\u6b63 \u5e38 \uff0c\u4f46\u7a7a\u8179\u80f0\u5c9b\u7d20\u6c34\u5e73\u5347\u9ad8\u3002<\/p>\n\n\n\n

Motta\u7b49\u7684\u53e6\u4e00\u7bc7\u6587\u732e\u663e\u793a \uff1aDHEA\u7684\u5904\u7406\u53ef\u5bfc\u81f4\u4f53\u91cd\u589e\u52a0 \uff0c\u80f0\u5c9b\u7d20\u62b5\u6297\u7b49\u4ee3\u8c22\u7279\u5f81\uff0c\u8fd9\u4e9b\u76f8\u4e92\u77db\u76fe\u7684\u7ed3\u679c\u53ef\u80fd\u4e0e\u5b9e\u9a8c\u6761\u4ef6\u7684\u53d8\u5316\u6709\u5173\u3002<\/p>\n\n\n\n

Motta\u7b49\u8fd8\u5bf9\u8fd9\u79cd\u52a8\u7269\u6a21\u578b\u7684\u514d\u75ab\u7cfb\u7edf\u8fdb\u884c\u4e86\u5206\u6790 \uff0c\u53d1\u73b0 DHEA\u5904\u7406\u53ef\u5bfc\u81f4\u5c0f\u9f20\u5375\u5de2T\u6dcb\u5df4\u7ec6\u80de\u7684\u6d78\u6da6\u589e\u52a0 \uff0c\u63d0\u793a\u514d\u75ab\u6c34\u5e73\u7684\u6539\u53d8\u53ef\u80fd\u4e0e PCOS\u7684\u53d1\u751f\u4e0e\u53d1\u5c55\u6709\u4e00\u5b9a\u7684\u5173\u7cfb\u3002<\/p>\n\n\n\n

\u76ee\u524d\u6709\u5f88\u591a\u5173\u4e8ePCOS\u60a3\u8005\u514d\u75ab\u6c34\u5e73\u53d8\u5316\u7684\u62a5\u9053 \uff0c\u5305\u62ec\u708e\u75c7\u56e0\u5b50c\u53cd\u5e94\u86cb\u767d\u548c\u53ef\u6eb6\u6027CIM0\u914d\u4f53\u6c34\u5e73\u7684\u589e\u52a0\u7b49 \u3002 \u8fd9\u79cd\u708e\u75c7\u72b6\u6001\u662f\u975e\u80a5\u80d6\u4f9d\u8d56\u7684\uff0c\u4f46\u662f\u4e0e\u80f0\u5c9b\u7d20\u62b5\u6297\u6709\u5f88\u5f3a\u7684\u76f8\u5173\u6027\u3002\u80f0\u5c9b\u7d20\u62b5\u6297\u5bfc\u81f4\u8840\u7cd6\u5347\u9ad8 \uff0c\u9ad8\u8840\u7cd6\u53ef\u4ee5\u542f\u52a8\u548c\u8c03\u8282\u5de8\u566c\u7ec6\u80de \uff0c\u4ece\u800c\u5f15\u8d77\u6162\u6027\u708e\u75c7\u3002 \u5728\u975e\u80a5\u80d6 PCOS\u60a3\u8005 \u4e2d\uff0c\u53e3\u670d\u8461\u8404\u7cd6\u53ef\u4ee5\u4e0a\u8c03\u5de8\u566c\u7ec6\u80deNF-B\u7684\u8868\u8fbe (Gonzalez\u7b49\uff0e2005)\u3002<\/p>\n\n\n\n

\u4f46 PCOS\u60a3\u8005\u7684\u708e\u75c7\u53cd\u5e94\u4e0e\u80f0\u5c9b\u7d20\u62b5\u6297\u4e4b\u95f4\u7684\u5173\u7cfb\u590d\u6742 \uff0c\u8fd8\u9700\u8fdb\u4e00\u6b65\u7684\u7814\u7a76 \u3002\u6700\u8fd1\u7684\u4e00\u7bc7\u7814\u7a76\u6307\u51fa \uff1a\u4e0d\u540c\u57fa\u56e0\u80cc\u666f\u7684\u5c0f\u9f20\u5bf9 DHEA\u8bf1\u5bfc\u7684\u53cd\u5e94\u5b58\u5728\u4e00\u5b9a\u7684\u5dee\u5f02\u3002<\/p>\n\n\n\n

Dowllng\u7b49\u7684\u7814\u7a76\u8868\u660eDHEA\u5728 C57BL\uff0f6J\u80cc\u666f\u4e0b\u8bf1\u5bfc\u7684PCOS\u5c0f\u9f20\u6a21\u578b\u6bd4BALB\uff0fc\u80cc\u666f\u4e0b\u8bf1\u5bfc\u7684\u5c0f\u9f20\u5728\u4ee3\u8c22\u65b9\u9762\u66f4\u63a5\u8fd1\u4e8ePCOS\u60a3\u8005\uff0cDHEA\u8bf1\u5bfc\u7684C57BL\uff0f6J \u5c0f\u9f20\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u7cd6\u8010\u91cf\u5f02\u5e38\u548c\u8f7b\u5ea6\u7684\u4f53\u91cd\u589e\u52a0 \u3002 \u56e0\u6b64\u4ed6\u4eec\u5efa\u8baeC57BL\uff0f6J\u54c1\u7cfb\u5728 PCOS\u7684\u7814\u7a76\u4e2d\u4f18\u4e8eBALB\uff0fc\u54c1\u7cfb\u5c0f \u9f20\uff0c\u80fd\u591f \u63d0\u4f9b\u4e00\u4e2a\u66f4\u4e3a\u5f3a\u5927\u7684\u5b9e\u9a8c\u5e73\u53f0\u3002<\/p>\n\n\n\n

\u53e6\u6709\u7814\u7a76\u6307\u51fa \uff1a21\u5929\u9f84\u7684C57BL\uff0f6J\u5c0f\u9f20\u7528DHEA\u8fde\u7eed\u5904\u7406 90\u5929\u5e76\u4e0d\u80fd\u8bf1\u5bfc\u51faPCOS\u7684\u8868\u578b \uff0c\u63d0\u793aDHEA\u7684\u5904\u7406\u65f6\u95f4\u548c\u8bf1\u5bfc\u65f6\u7a0b\u5728\u5efa\u7acb P- COS\u5c0f\u9f20\u6a21\u578b\u65f6\u7684\u91cd\u8981\u6027 \u3002<\/p>\n\n\n\n

\u9ad8\u8102\u9972\u6599<\/a> (highfatdiet\uff0cHFD<\/a>)\u4e0d\u4ec5\u53ef\u4ee5\u8bf1\u5bfc\u7cd6\u5c3f\u75c5\u548c\u80a5\u80d6 \uff0c\u800c\u4e14\u8fd8\u53ef\u5bfc\u81f4\u5375\u5de2\u7684\u8102\u6bd2\u6027\u548c\u4e0d\u5b55\u3002\u56e0\u6b64\u6211\u4eec\u5728\u5b9e\u9a8c\u4e2d\u7528 DHEA(6\u6beb \u514b\uff0f100 \u514b)\u5bf9 25\u5929\u5927\u7684 C57BL\uff0f6J\u96cc\u9f20\u8fde\u7eed\u5904\u7406 20\u5929\u65f6\uff0c \u540c\u65f6\u7ed9\u4e88\u5c0f\u9f20 60\uff05\u7684\u9ad8\u8102\u996e\u98df<\/a>\u3002\u5b9e\u9a8c\u7ed3\u679c\u8868\u660eDHEA\u4e0eHFD\u7684\u8054\u5408\u5e94\u7528\u8bf1\u5bfc\u51fa\u4e86 PCOS\u7684\u751f\u6b96\u8868 \u578b \uff0c\u5373 \uff1a\u6027\u5468\u671f\u7d0a\u4e71 \uff0c\u591a\u6570\u5c0f\u9f20\u7684\u6027\u5468\u671f\u505c\u7559\u5728\u67d0\u4e00\u4e2a\u6216\u8005\u4e24\u4e2a\u65f6\u671f \uff0c\u8fd9\u4e0e PCOS\u60a3\u8005\u7684\u6708\u7ecf\u5468\u671f\u7d0a\u4e71\u76f8\u4e00\u81f4 \uff1b\u8840\u6e05\u4e2d\u7684\u96c4\u6fc0\u7d20\u6c34\u5e73\u660e\u663e\u5347\u9ad8 \uff1b\u5f62\u6001\u5b66\u68c0\u6d4b\u663e\u793a\u5375\u5de2\u5448\u73b0\u660e\u663e\u7684\u591a\u56ca\u5316 \u3001\u9897\u7c92\u7ec6\u80de\u5c42\u53d8\u8584 \u3001\u5c01\u95ed \u5375\u6ce1\u589e\u52a0\u3001\u9ec4\u4f53\u6570\u91cf\u51cf\u5c11 \uff0c\u63d0\u793a\u6392\u5375\u51cf\u5c11\u6216\u4e0d\u6392\u5375 \u3002 \u53e6\u4e00\u65b9\u9762 \uff0cDHEA\u52a0HFD\u8bf1\u5bfc\u7684\u5c0f\u9f20\u4f53\u91cd\u660e\u663e\u589e\u52a0\uff0c\u4e0e\u4e34\u5e8a\u4e0aPCOS\u60a3\u8005\u591a\u4f34\u6709\u80a5\u80d6\u76f8\u5bf9\u5e94\u3002\u80f0\u5c9b\u7d20\u62b5\u6297\u4e00\u76f4\u88ab\u89c6\u4e3aPCOS\u60a3\u8005\u9664\u9ad8\u96c4\u6fc0\u7d20\u8840\u75c7\u5916\u7684\u53e6\u4e00\u91cd\u8981\u7279\u5f81\u548c\u53d1\u75c5\u56e0\u7d20 \uff0c\u5728 PCOS\u7684\u53d1\u751f\u548c\u53d1\u5c55\u4e2d\u90fd\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

DHEA\u4e0eHFD\u7684\u8054\u5408\u5e94\u7528\u6210\u529f\u5730\u5728\u5c0f\u9f20\u4e2d\u8bf1\u5bfc\u51fa\u4e86\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u7cd6\u8010\u91cf\u5f02\u5e38\u7684\u8868\u578b\u3002\u540c\u65f6 \uff0c\u5c0f\u9f20\u8fd8\u8868\u73b0\u51fa\u4e86\u7c7b PCOS\u60a3\u8005\u9ad8\u8102\u8840\u75c7 \u3001\u809d\u810f\u8102\u8d28\u7684\u6c89\u79ef\u548c\u8102\u80aa\u7ec6\u80de\u589e\u5927\u7b49\u73b0\u8c61 \u3002<\/p>\n\n\n\n

\u7efc\u4e0a\u6240\u8ff0 \uff0c\u7528DHEA\u5bf925\u5929\u9f84\u7684C57BL\uff0f6J\u96cc\u9f20\u5904\u7406\u80fd\u591f\u8bf1\u5bfc\u51faPCOS\u60a3\u8005\u7684\u751f\u6b96\u8868\u578b\u548c\u90e8\u5206\u4ee3\u8c22\u8868\u578b \uff0c\u5982\u679c\u540c\u65f6\u7ed9\u4e88HFD\u5904\u7406 \uff0c\u5219\u80fd\u591f\u5728\u6b64\u57fa\u7840\u4e0a\u8bf1\u5bfc\u51fa\u66f4\u591a\u7684\u7c7b PCOS\u60a3\u8005\u7684\u4ee3\u8c22\u8868\u578b\u3002<\/p>\n\n\n\n

(\u4e09 )\u53cc\u6c22\u777e\u916e (dihydrotestosterone\uff0cDHT)<\/strong><\/p>\n\n\n\n

DHT\u662f\u7531\u777e\u916e\u7ecf5or-\u8fd8\u539f\u9176\u50ac\u5316\u800c\u4ea7\u751f\u7684\u4e00\u79cd\u4e0d\u80fd\u88ab\u8f6c\u5316\u4e3a\u96cc\u6fc0\u7d20\u7684\u96c4\u6fc0\u7d20\u3002<\/p>\n\n\n\n

\u6587\u732e\u62a5\u9053\u5728\u5c0f\u9f20\u7684\u6000\u5b55 \u671f\u548c\u9752\u6625\u671f\u4e24\u4e2a\u65f6\u671f \uff0cDHT\u88ab\u7528\u4e8e\u8bf1\u5bfcPCOS\u7684\u52a8\u7269\u6a21\u578b\u3002\u5728\u6bcd\u9f20\u6000\u5b55\u7684\u7b2c 16\uff5e18\u5929\u7ed9\u4e88250\u5fae\u514bDHT\u5904\u7406\u53ef\u4ee5\u5bfc\u81f4\u5b50\u4ee3\u96cc\u6027\u5c0f\u9f20\u7684\u751f\u6b96\u529f\u80fd \u7d0a \u4e71 \u3002\u8fd9\u79cd\u4ea7\u524d\u5904\u7406\u4f1a\u5bfc\u81f4\u5c0f\u9f20\u5728\u6210\u5e74\u540e\u8868\u73b0\u51fa\u6027\u5468\u671f\u7d0a\u4e71 \uff0c\u7279\u522b\u662f\u6027\u5468\u671f\u663e\u8457\u5ef6\u957f\uff0c\u800c\u52a8\u60c5\u671f\u5219\u76f8\u5bf9\u53d8\u77ed\uff1b\u5375\u5de2\u5f62\u6001\u6539\u53d8 \uff0c\u5c0f\u7684\u7aa6\u6027\u5375\u6ce1\u589e\u52a0 \uff0c\u800c\u9ec4\u4f53\u7f3a\u5c11 \uff0c\u5375\u6ce1\u7684\u9897\u7c92\u7ec6\u80de\u5c42\u53d8\u8584\uff0c\u819c\u7ec6\u80de\u5c42\u6709\u8f7b\u5ea6\u7684\u589e\u539a \uff0c\u540c\u65f6\u5c0f\u9f20\u7684\u751f\u6b96\u80fd\u529b\u660e\u663e\u964d\u4f4e \uff0c\u8840\u6e05\u4e2d\u7684\u777e\u916e\u548c LH\u6c34\u5e73\u5347\u9ad8 \u3002\u53e6\u4e00\u65b9\u9762 \uff0c\u4ea7\u524d\u5904\u7406\u4e5f\u8bf1\u5bfc\u51fa\u4e86\u4e00\u7cfb\u5217\u7684\u4ee3\u8c22\u7279\u5f81 \uff0c\u5305\u62ec\u7a7a\u8179\u8840\u7cd6\u5347\u9ad8\u548c\u7cd6\u8010\u91cf\u5f02\u5e38\u3002 \u8fd9\u4e9b\u5f02\u5e38\u4e0d\u4f9d\u8d56\u4e8e\u5e74\u9f84 \uff0c\u5374\u4e0e\u80f0 \u5c9b\u7d20 \u7684\u5206\u6ccc\u6709\u4e00\u5b9a\u5173\u7cfb\u3002\u7ec4\u7ec7\u5206\u6790\u8fd8\u663e\u793a\u5c0f\u9f20\u7684\u8102\u80aa\u7ec6\u80de\u53d8\u5927 \uff0c\u800c\u4e14\u809d\u810f\u8102\u8d28\u6c89\u79ef\uff0c\u4f46\u662f\u4f53\u91cd\u548c\u8102\u80aa\u7684\u91cd\u91cf\u6bd4\u672a\u6539\u53d8\u3002<\/p>\n\n\n\n

\u540c\u65f6 \uff0c\u7814\u7a76\u8005\u6307\u51fa\u8fd9\u79cd\u6a21\u578b\u8868\u73b0\u51fa\u4e86GnRH\u795e \u7ecf\u5143\u7684\u9ad8\u53cd\u5e94\u6027 \uff0cGnRH\u7684\u5206\u6ccc\u9891\u7387\u4e5f\u52a0\u5feb \uff0c\u8868\u660e\u9ad8\u96c4\u6fc0\u7d20\u6c34\u5e73\u53ef\u80fd\u6539\u53d8\u4e86\u7c7b\u56fa\u9187\u6fc0\u7d20\u7684\u56de\u9988\u8c03\u8282\u4fe1\u53f7\u3002<\/p>\n\n\n\n

\u6700\u8fd1\u7684\u4e00\u7bc7\u7814\u7a76\u663e\u793a\u5c06\u542b\u6709 2.5\u6beb\u514b DHT\u7684\u7f13\u91ca\u6cf5\u57cb\u4eba19\u5929\u9f84 \u7684\u5c0f\u9f20\u4f53\u5185\uff0c\u8fde\u7eed\u5904\u7406 90\u5929\u540e\u80fd\u8bf1\u5bfc\u51fa\u4e0ePCOS\u60a3\u8005\u7c7b\u4f3c\u7684\u751f\u6b96\u548c\u4ee3\u8c22\u8868\u578b\u3002\u8fd9\u79cdDHT\u7684\u957f\u671f\u5904\u7406\u5bfc\u81f4\u5c0f\u9f20\u7684\u6027\u5468\u671f\u7d0a\u4e71\u3001\u9ec4\u4f53\u7f3a\u5931\u7b49\u8868\u73b0 \uff0c\u5375\u5de2\u5448\u591a\u56ca\u6837\u7ed3\u6784 \uff0c\u540c\u65f6\u5375\u5de2\u4e2d\u542b\u6709\u5927\u91cf\u7684\u95ed\u9501\u5375\u6ce1\u3001\u56ca\u6027\u7a7a\u6ce1\u7684\u819c\u7ec6\u80de\u5c42\u589e\u751f\u3001\u9897\u7c92\u7ec6\u80de\u5c42\u53d8\u8584 \uff0c\u4f46\u662f\u7aa6\u524d\u5375\u6ce1\u548c\u5c0f\u7684\u7aa6\u6027\u5375\u6ce1\u7684\u6570\u91cf\u5e76\u672a\u589e\u52a0\u3002\u5375\u5de2\u7684\u91cd\u91cf\u6709\u5347\u9ad8\u7684\u8d8b\u52bf \uff0c\u8fd9\u4e0e\u7528\u540c\u6837\u65b9\u6cd5\u5904\u7406\u7684\u5927\u9f20\u7684\u7ed3\u679c\u76f8\u53cd \uff0c\u7814\u7a76\u8005\u8ba4\u4e3a\u8fd9\u53ef\u80fd\u662f\u4e0e\u5927\u9f20\u548c\u5c0f\u9f20\u6700\u7ec8\u7684\u96c4\u6fc0\u7d20\u6c34\u5e73\u4e0d\u4e00\u81f4\u6709\u5173 \u3002\u8840\u6e05\u4e2d\u96c4\u6fc0\u7d20\u6c34\u5e73\u660e\u663e\u5347\u9ad8\uff0c\u4f46\u662fLH\u6c34\u5e73\u4e0b\u964d\u3002DHT\u7684\u957f\u671f\u5904\u7406\u8fd8\u5bfc\u81f4\u5c0f \u9f20\u7684\u4f53\u91cd\u548c\u8102\u80aa\u542b\u91cf\u589e\u52a0\u3001\u8102\u80aa\u7ec6\u80de\u7684\u76f4\u5f84\u589e\u5927 \uff0c\u4ee5\u53ca\u8102\u80aa\u56e0\u5b50\u5206\u6ccc\u7d0a\u4e71 \uff0c\u5176\u4e2d\u4e3b\u8981\u662f\u7626\u7d20\u6c34\u5e73\u7684\u964d\u4f4e\u548c\u8102\u8054\u7d20\u6c34\u5e73\u7684\u5347\u9ad8\u3002\u8102\u80aa\u56e0\u5b50\u5bf9\u4e8e\u4ee3\u8c22\u548c\u751f\u6b96\u7684\u53d8\u5316\u8d77\u7740\u91cd\u8981\u4f5c\u7528 \uff0c\u4f8b\u5982\u7626\u7d20\u80fd\u591f\u8bf1\u5bfcLH\u7684\u5206\u6ccc \uff0c\u540c\u65f6\u6291\u5236FSH\u8bf1\u5bfc\u7684\u82b3\u9999\u9176\u7684\u8868\u8fbe\uff0c\u6240\u4ee5\u8102\u80aa\u56e0\u5b50\u5206\u6ccc\u7684\u6539\u53d8\u53ef\u80fd\u53c2\u4e0e\u4e86 PCOS\u7684\u53d1\u751f\u548c\u53d1\u5c55\u8fc7\u7a0b \u3002<\/p>\n\n\n\n

DHT\u7684\u957f\u671f\u5904\u7406\u8fd8\u5bfc\u81f4\u5c0f\u9f20\u51fa\u73b0\u7cd6\u8010\u91cf\u5f02\u5e38 \uff0c\u4f46\u662f\u7a7a\u8179\u8840\u7cd6\u548c\u80f0\u5c9b\u7d20\u6c34\u5e73\u5e76\u672a\u6539\u53d8 \u3002DHT\u4f5c\u4e3a\u4e00\u79cd\u5e38\u7528\u7684\u96c4\u6fc0\u7d20 \uff0c\u5176\u8bf1\u5bfc \u7684 PCOS\u5c0f\u9f20\u6a21\u578b\u8868\u73b0\u51fa\u4e86\u8bf8\u591a\u4e0e\u4e34\u5e8a\u4e00\u81f4\u7684\u8868\u578b \uff0c\u7279\u522b\u662f DHT\u7684\u957f\u671f\u5904\u7406\u53ef\u4ee5\u4f7f\u5c0f\u9f20\u8868\u73b0\u51faPCOS\u7684\u751f\u6b96\u548c\u4ee3\u8c22\u4e24\u4e2a\u65b9\u9762\u7684\u7279\u5f81\u3002\u4f46\u662f PCOS\u7684\u8bb8\u591a\u4ee3\u8c22\u7d0a\u4e71 \u7279\u5f81 \uff0c\u6bd4\u5982\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u4e0b\u964d\u3001\u8840\u8102\u7d0a\u4e71 \u3001\u8102\u80aa\u809d\u7b49\u5c1a\u672a\u5728\u6b64\u5c0f\u9f20\u6a21\u578b\u4e2d\u62a5\u9053\u3002\u6b64\u5916\uff0c\u8be5\u6a21\u578b\u7684\u8bf1\u5bfc\u65f6\u7a0b\u4e3a90\u5929 \uff0c\u6a21\u578b\u5efa\u7acb\u65f6 \u9f20\u7ea6\u4e3a 3.5\u6708\u9f84 \uff0c\u5e74\u9f84\u4e5f\u662f\u7814\u7a76\u8005\u5728\u9009\u62e9\u5c0f\u9f20\u6a21\u578b\u65f6\u9488\u5bf9\u7814\u7a76\u76ee\u7684\u5e94\u8003\u8651\u7684\u4e00\u4e2a\u56e0\u7d20\u3002<\/p>\n\n\n\n

\u4e8c\u3001\u96cc\u6fc0\u7d20\u548c\u6765\u66f2\u5511\u8bf1\u5bfc\u7684PCOS\u5c0f\u9f20\u6a21\u578b<\/strong><\/p>\n\n\n\n

PCOS\u5c0f\u9f20\u6a21\u578b\u9664\u4e86\u5e38\u7528\u96c4\u6fc0\u7d20\u6765\u8bf1\u5bfc\u5916 \uff0c\u8fd8 \u6709\u4e00\u4e9b\u5176\u4ed6\u65b9\u6cd5 \uff0c\u6bd4\u5982\u7528\u96cc\u6fc0\u7d20\u6216\u82b3\u9999\u9176\u6291\u5236\u5242\u6765\u66f2\u5511\u6765\u5904\u7406\u5c0f \u9f20\u3002<\/p>\n\n\n\n

(\u4e00)\u96cc\u6fc0\u7d20(estrogens\uff0cE)<\/strong><\/p>\n\n\n\n

\u96cc\u6fc0\u7d20\u662f\u96c4\u6fc0\u7d20\u5728\u9897\u7c92\u7ec6\u80de\u4e2d\u7ecf\u82b3\u9999\u5316\u9176 P450\u50ac\u5316\u8f6c\u53d8\u800c\u6765\u7684\uff0c\u5bf9 \u4e8e\u5973\u6027\u6b63\u5e38\u7684\u6392\u5375\u548c\u5b50\u5bab\u529f\u80fd\u7684\u7ef4\u6301\u7b49\u8d77\u91cd\u8981\u4f5c \u7528\u3002\u6709\u62a5\u9053\u6307\u51fa\u90e8\u5206PCOS\u60a3\u8005\u7684\u96cc\u6fc0\u7d20\u6c34\u5e73\u5347\u9ad8\u3002<\/p>\n\n\n\n

\u96cc\u6fc0\u7d20\u8bf1\u5bfc\u7684 PCOS\u5c0f\u9f20\u6a21\u578b\u4e3b\u8981\u5229\u7528 5\uff5e7 \u5929\u9f84\u7684\u65b0\u751f\u5c0f \u9f20 \uff0c\u901a\u8fc7\u6bcf\u5929\u76ae\u4e0b\u6ce8\u5c0420\u5fae\u514b\u7684\u96cc\u6fc0\u7d20 \uff0c\u4f7f\u5c0f\u9f20\u5728\u6210\u5e74\u540e\u8868\u73b0\u51fa\u5375\u5de2\u591a\u56ca\u5316\u548c\u9ec4\u4f53\u7f3a\u5c11 \u3002<\/p>\n\n\n\n

Chapman\u7b49\u4e3b\u8981\u5bf9\u6a21\u578b\u4e2d\u514d\u75ab\u7cfb\u7edf\u548c\u751f\u6b96\u7cfb\u7edf\u7684\u5173\u7cfb\u8fdb\u884c\u4e86\u63a2\u8ba8 \uff0c\u53d1\u73b0\u80f8\u817a\u5207\u9664\u7684\u5c0f\u9f20\u6ce8\u5c04\u96cc\u6fc0\u7d20\u540e\u5e76\u4e0d\u80fd\u5f15\u8d77 \u5375\u5de2\u591a\u56ca\u5316\u548c\u9ec4\u4f53\u7f3a\u5c11 \uff0c\u8bf4\u660e\u514d\u75ab\u6c34\u5e73\u7684\u6539\u53d8\u4e0e\u5375\u5de2\u7684\u5f62\u6001\u548c\u529f\u80fd\u7684\u53d8\u5316\u6709\u5173 \uff0c\u8fd9 \u4e00 \u70b9\u4e5f\u4e0e\u524d\u9762\u6240\u63d0\u53ca\u7684 DHEA\u8bf1\u5bfc\u7684 PCOS\u6a21\u578b\u4e2d\u514d\u75ab\u6c34\u5e73\u53d1\u751f\u4e86\u6539\u53d8\u7684\u7ed3\u679c\u76f8\u4e00\u81f4\u3002\u7136\u800c\u7814\u7a76\u4e2d\u6ca1\u6709\u5173\u4e8e\u6fc0\u7d20\u6c34\u5e73\u548c\u4ee3\u8c22\u65b9\u9762\u7684\u6570\u636e\u3002<\/p>\n\n\n\n

(\u4e8c )\u6765\u66f2\u5511<\/strong><\/p>\n\n\n\n

\u6765\u66f2\u5511(letrozole)\u662f\u4e00\u79cd\u82b3\u9999\u9176\u6291\u5236\u5242 \uff0c\u80fd\u591f\u963b\u6b62\u96c4\u6fc0\u7d20\u8f6c\u5316\u4e3a\u96cc\u6fc0\u7d20 \uff0c\u4f7f\u5185\u6e90\u6027\u7684\u96c4\u6fc0\u7d20\u6c34\u5e73\u5347\u9ad8 \uff0c\u56e0\u6b64\u6765\u66f2\u5511\u4e5f\u88ab\u7528\u4e8e\u8bf1\u5bfcPCOS\u7684\u52a8\u7269\u6a21\u578b \u3002\u5bf9 21\u5929\u9f84\u7684\u96cc\u9f20\u75288\u6beb\u514b\u6765\u66f2\u5511\u5305\u57cb\u7f13\u91ca\u6cf5\u8fde\u7eed\u5904\u7406 90\u5929\uff0c\u53ef\u4ee5\u5bfc\u81f4\u5c0f\u9f20\u6027\u5468\u671f\u7d0a\u4e71 \u3001\u7a00\u53d1\u6392\u5375\u548c\u5375\u5de2\u591a\u56ca\u5316 \uff0c\u540c\u65f6\u5375\u5de2\u6709\u56ca\u6027\u51fa\u8840 \uff0c \u4f46\u662f\u5c0f\u9f20\u5e76\u6ca1\u6709\u8868\u73b0 \u51fa\u4ee3\u8c22\u65b9\u9762\u7684\u7279\u5f81 \u3002<\/p>\n\n\n\n

\u4e09 \u3001\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u548c\u8f6c\u57fa\u56e0\u5c0f\u9f20\u7684PCOS\u6a21\u578b<\/strong><\/p>\n\n\n\n

\u73b0\u6709\u7814\u7a76\u8ba4\u4e3a PCOS\u5177\u6709\u4e00\u5b9a\u7684\u9057\u4f20\u76f8\u5173\u6027 \uff0c \u4f46\u4e0d\u662f\u5355\u57fa\u56e0\u9057\u4f20 \uff0c\u800c\u662f\u8868\u73b0\u4e3a\u591a\u57fa\u56e0\u7684\u76f8\u5173\u6027 \u3002 \u8f6c\u57fa\u56e0\u52a8\u7269\u5728\u7814\u7a76\u75be\u75c5\u7684\u53d1\u751f\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u5df2\u7ecf\u6210\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u7814\u7a76\u624b\u6bb5 \uff0c\u80fd\u591f\u4e3a\u66f4\u597d\u5730\u7406\u89e3\u67d0\u4e00\u57fa\u56e0\u5728\u75be\u75c5\u53d1\u751f\u53d1\u5c55\u8fc7\u7a0b\u7684\u4f5c\u7528\u63d0\u4f9b\u975e\u5e38\u6709\u6548\u7684\u65b9\u6cd5 \u3002\u968f\u7740\u7814\u7a76\u7684\u4e0d\u65ad\u6df1\u5165 \uff0c\u4e00\u4e9b\u8f6c\u57fa \u56e0\u52a8\u7269\u4e5f\u88ab\u62a5\u9053\u5177\u6709\u7c7b PCOS\u6837\u7684\u8868\u578b\u3002<\/p>\n\n\n\n

(\u4e00 )\u7626\u7d20\u7f3a\u4e4f (ob\uff0fob)\u548c\u7626 \u7d20\u53d7\u4f53\u7f3a\u4e4f (db\uff0f db)\u7684\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u7626\u7d20\u662f\u4e00\u79cd\u7531\u8102\u80aa\u7ec6\u80de\u5408\u6210\u548c\u5206\u6ccc\u7684\u6fc0\u7d20\uff0c\u80fd\u591f\u6291\u5236\u98df\u6b32\u3001\u4fc3\u8fdb\u80fd\u91cf\u6d88\u8017\u3001\u8c03\u8282\u4ee3\u8c22\u3002<\/p>\n\n\n\n

\u7626\u7d20\u6c34\u5e73\u5347\u9ad8\u4e5f\u662fPCOS\u60a3\u8005\u7684\u7279\u70b9\u4e4b\u4e00\u3002\u7531\u4e8e\u7626\u7d20\u53ef\u4ee5\u76f4\u63a5\u523a\u6fc0 GnRH\u7684\u5206\u6ccc \uff0c\u800c\u4e0b\u4e18\u8111\u7684GnRH\u5206\u6ccc\u5f02\u5e38\u4e5f\u662fPCOS\u60a3\u8005\u7684\u7279\u5f81\u4e4b\u4e00 \uff0c\u6240\u4ee5\u6709\u6587\u732e\u62a5\u9053\u7626\u7d20\u4fe1\u53f7\u901a\u8def\u7684\u6539\u53d8\u53ef\u80fd\u53c2\u4e0e\u4e86PCOS\u7684\u53d1\u751f\u53d1\u5c55\u3002ob\uff0fob\u5c0f \u9f20 (Harem \u7b49\uff0e2004)\u548c db\uff0fdb\u5c0f \u9f20 (Garris\u7b49\uff0e1989)\u5c55\u793a\u51fa\u4e00\u7cfb\u5217\u7684\u7c7bPCOS\u7684\u751f\u6b96\u548c\u4ee3\u8c22\u7279\u5f81 \uff0c\u5982 \uff1a\u6210\u5e74\u7684\u96cc\u6027\u5c0f\u9f20\u8868\u73b0\u51fa\u751f\u6b96\u80fd\u529b\u4f4e\u4e0b \u3001\u6027\u5468\u671f\u7d0a\u4e71 \u3001\u4e0d\u6392\u5375\u3001\u5c01\u95ed\u5375\u6ce1\u7684\u6570\u91cf\u589e\u52a0\u3002\u6b64 \u5916 \uff0cob\uff0fob\u5c0f \u9f20\u8840\u6e05\u4e2d\u7684\u96cc\u6fc0\u7d20\u3001\u96c4\u6fc0\u7d20\u548c\u5b55\u6fc0\u7d20\u6c34\u5e73\u8fd8\u660e\u663e\u5347\u9ad8 \uff0cFSH\u7684\u6c34\u5e73\u964d\u4f4e \uff0c\u4f46 db\uff0fdb\u5c0f\u9f20\u7684\u96cc\u6fc0\u7d20\u548c\u5b55\u6fc0\u7d20\u6c34\u5e73\u90fd\u4f4e\u4e8e\u6b63\u5e38\u3002\u540c\u65f6 \uff0c\u4e24\u79cd\u5c0f \u9f20\u90fd\u8868\u73b0\u51fa\u4e86\u80a5\u80d6 \u3001\u9ad8\u8840\u7cd6 \u3001\u7cd6\u8010\u91cf\u5f02\u5e38\u548c\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\u7b49\u4ee3\u8c22\u8868\u73b0\u3002\u9057\u61be\u7684\u662f \uff0c\u8fd9\u4e24\u79cd\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u90fd\u6ca1\u6709\u5448\u73b0\u5375\u5de2\u591a\u56ca\u5316 \u3002<\/p>\n\n\n\n

(\u4e8c)\u963f\u7247-\u4fc3\u9ed1\u8272\u7d20\u76ae\u8d28\u795e\u7ecf\u5143 (pro\u2014opiome1 anocortinneurons\uff0cPOMC)\u7684\u7626\u7d20\u53d7\u4f53\u548c\u80f0\u5c9b\u7d20\u53d7\u4f53\u9009\u62e9\u6027\u6572\u9664(IR\uff0fLepPoMc)\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\u548c\u9ad8\u96c4\u6fc0\u7d20\u8840\u75c7\u662fPCOS\u60a3\u8005\u6700\u4e3a\u5e38\u89c1\u7684\u75c7\u72b6 \uff0c\u5bf9 PCOS\u60a3\u8005\u7684\u751f\u6b96\u548c\u4ee3\u8c22\u8868\u578b\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u4e0b\u4e18\u8111\u7684POMC\u795e\u7ecf\u5143\u662f\u673a\u4f53\u8c03\u8282\u80fd\u91cf\u4ee3\u8c22\u548c\u7cd6\u7a33\u6001\u7684\u9ad8\u7ea7\u795e\u7ecf\u4e2d\u67a2 \uff0c\u80f0\u5c9b\u7d20\u548c\u7626\u7d20\u53d7\u4f53\u5728 POMC\u795e\u7ecf \u5143\u4e2d\u4e5f\u6709\u8f83\u9ad8\u7684\u8868\u8fbe\u3002\u4e0b\u4e18\u8111\u7626\u7d20\u53d7\u4f53\u548c\u80f0\u5c9b\u7d20\u53d7\u4f53\u7279\u5f02\u6027\u6572\u9664\u7684\u5c0f\u9f20(IR\uff0fLepP0Mc)\u8868\u73b0\u51fa\u660e\u663e\u7684\u4ee3\u8c22\u7d0a\u4e71 \uff0c\u5305\u62ec\u57fa\u7840\u80f0\u5c9b\u7d20\u6c34\u5e73\u5347\u9ad8\u3001\u7cd6\u8010\u91cf\u5f02\u5e38\u3001\u80f0\u5c9b\u7d20\u62b5\u6297 \u3001\u4f53\u8102\u548c\u4f53\u91cd\u90fd\u5347\u9ad8\u3002\u540c\u65f6 \uff0c\u8fd9\u79cd\u5c0f\u9f20\u7684LH\u548c\u96c4\u6fc0\u7d20\u6c34\u5e73\u5347\u9ad8 \uff0c\u5375\u5de2\u7684\u5f62\u6001\u4e5f\u53d1\u751f\u4e86\u6539\u53d8 \uff0c \u4e0e\u6b63\u5e38\u5c0f\u9f20\u76f8\u6bd4\u6709\u8f83\u591a\u7684\u9000\u5316\u5375\u6ce1 \uff0c\u5076\u5c14\u4e5f\u80fd\u89c1\u5230\u56ca\u6027\u5375\u6ce1\u3002\u7814\u7a76\u8005\u6307\u51fa\u8fd9\u79cd\u5c0f\u9f20\u5728\u4f53 \u91cd\u548c\u8102 \u80aa\u542b\u91cf\u589e\u52a0\u7684\u540c\u65f6\u4e5f\u5b58\u5728\u8f7b\u5ea6\u7684\u6162\u6027\u708e\u75c7\u53cd\u5e94 \uff0c\u8fd9\u4e9b\u708e\u75c7\u53cd\u5e94\u8fdb\u4e00\u6b65\u5f71\u54cd\u4e86\u809d\u810f\u5bf9\u7cd6\u4ee3\u8c22\u7684\u8c03\u8282 \u3001\u808c\u8089\u5bf9\u80f0\u5c9b\u7d20\u654f\u611f\u6027 \u3001\u8102\u80aa\u529f\u80fd\u7684\u7d0a\u4e71\u4ee5\u53ca\u5375\u5de2\u7684\u5f62\u6001\u5b66\u548c\u529f\u80fd\u7684\u53d8\u5316 \u3002<\/p>\n\n\n\n

(\u4e09)\u96cc\u6fc0\u7d20\u53d7\u4f53(estrogenreceptor\uff0cER)\u03b1\u6572\u9664\u548c\u82b3\u9999\u5316\u9176 (aromatase\uff0cCYP19)\u6572\u9664\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

ER\u03b1 \u548c CYP19\u6572\u9664\u5c0f\u9f20\u7684\u672c\u8d28\u90fd\u662f\u5c0f\u9f20\u4f53\u5185\u7684\u96cc\u6fc0\u7d20\u4fe1\u53f7\u901a\u8def\u88ab\u7834\u574f \uff0c\u6240\u4ee5\u8fd9\u4e24\u79cd\u5c0f\u9f20\u6709\u5f88\u591a\u76f8\u4f3c\u7684\u8868\u578b(Britt\u7b49\uff0e2000\uff0cCouse\u7b49\uff0e1999)\uff0c\u6bd4\u5982 \uff1a\u7531\u4e8e\u7f3a\u4e4f\u4e86\u96cc\u6fc0\u7d20\u7684\u8d1f\u53cd\u9988\u4f5c\u7528 \uff0c\u5bfc\u81f4LH \u7684\u6c34\u5e73\u5347\u9ad8 \uff1b\u5375\u5de2\u8868\u73b0\u51fa\u56ca\u6027\u51fa\u8840 \u3001\u4e0d\u6392\u5375\u7b49\u3002<\/p>\n\n\n\n

\u6b64\u5916 \uff0cCYP19\u6572\u9664\u5c0f \u9f20\u8868\u73b0\u51fa\u5375\u6ce1\u53d1\u80b2\u5f02\u5e38 \u3001\u5927\u91cf\u7684\u5de8\u566c\u7ec6\u80de\u548c\u80f6\u539f\u7ea4\u7ef4\u6c89\u79ef\u5728\u5375\u5de2 \uff0c\u800c ER\u03b1\u6572\u9664\u7684\u5c0f\u9f20\u671f\u7ed9\u4e88GnRH \u62ee\u6297\u5242\u540e\u5219\u53ef\u4ee5\u964d\u4f4eLH\u7684\u6c34\u5e73 \uff0c\u540c\u65f6\u5375\u5de2\u7684\u591a\u56ca\u5316\u4e5f\u5f97\u5230\u6539\u5584 \u3002<\/p>\n\n\n\n

(\u56db)\u8fc7\u8868\u8fbe\u4eba\u7ed2\u6bdb\u4fc3\u6027\u817a\u6fc0\u7d20(human chofionic gonadotrophin\uff0chCG)\u03b2\u4e9a\u57fa\u548c\u4fc3\u9ec4\u4f53\u751f\u6210\u7d20 (luteotropic hormone\uff0cLH)\u03b2\u4e9a\u57fa\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

LH\u5206\u6ccc\u589e\u52a0\u662fPCOS\u7684\u4e00\u4e2a\u7279\u5f81\u3002hCG\u4e0eLH\u540c\u5c5e\u4e00\u4e2a\u5bb6\u65cf \uff0c \u4ed6\u4eec\u5171\u4eab\u4e00\u4e2a\u03b1\u4e9a\u57fa \uff0c\u5e76\u4e14 \u4e8c\u8005\u7684\u53d7\u4f53\u975e\u5e38\u76f8\u4f3c \u3002 \u8fc7\u8868\u8fbe hCG\u03b2\u6216\u4eba LH\u03b2\u7684\u5c0f\u9f20\u8868\u578b\u5728\u67d0\u4e9b\u65b9\u9762\u5341\u5206\u76f8\u4f3c (Matzuk\u7b49\uff0e2003\uff0cRisma\u7b49\uff0e1995)\uff0c\u90fd\u8868\u73b0\u51fa\u6392\u5375\u80fd\u529b\u4e0b\u964d\u3001\u4e0d\u5b55 \u3001\u8840\u6e05\u96cc\u6fc0\u7d20\u6c34\u5e73\u5347\u9ad8 \u3001\u4ee5\u53ca\u5375\u5de2\u51fa\u73b0\u591a\u56ca\u5316 \u3002hCG\u03b2\u8f6c\u57fa\u56e0\u96cc\u9f20\u8fd8\u8868\u73b0\u51fa\u80be\u810f\u548c\u8180\u80f1\u53d8\u5927 \uff0c\u800c LH\u03b2\u8f6c\u57fa\u56e0\u5c0f\u9f20\u5219\u6709\u96c4\u6fc0\u7d20\u6c34\u5e73\u5347\u9ad8 \u3001\u80a5\u80d6 \u3001\u8179\u90e8\u8102\u80aa\u7684\u6c89\u79ef\u589e\u52a0 \u3001\u80f0\u5c9b\u7d20\u6c34\u5e73\u5347\u9ad8\u7b49\u4ee3\u8c22\u8868\u578b\u3002<\/p>\n\n\n\n

\u540c\u65f6 \uff0cLH\u03b2\u5c0f\u9f20\u8fd8\u5b58\u5728\u4e00\u4e9b\u4e0ePCOS\u65e0\u5173\u7684\u8868\u578b \uff0c\u6bd4\u5982 \uff1a\u5782\u4f53\u817a\u7624 \u3001\u4e73\u817a\u56ca\u80bf\u3001\u5375\u5de2\u80bf\u7624 \u3001\u5375\u5de2\u4e2d\u9ec4\u4f53\u6570\u91cf\u589e\u52a0\u7b49\u3002<\/p>\n\n\n\n

\u8fd9\u4e9b\u7ed3\u679c\u8bf4\u660e hCG\u548c LH\u6709\u53ef\u80fd\u53c2\u4e0e\u4e86PCOS\u7684\u75c5\u56e0 \uff0c\u5c24\u5176\u662f\u5375\u5de2\u591a\u56ca\u5316\u7684\u5f62\u6210\u8fc7\u7a0b \uff0c\u4f46 hCG\u548c LH PCOS\u7684\u53d1\u751f\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528\u9700\u8fdb\u4e00\u6b65\u7684\u7814\u7a76 \u3002<\/p>\n\n\n\n

(\u4e94)\u8fc7\u8868\u8fbe\u4eba\u7ea4\u6eb6\u9176\u539f\u542f\u52a8\u7269\u6291\u5236\u5242-1(plasminogen activator inhibitor-1\uff0cPAI-1)\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

PAI-1\u662f\u4e1d\u6c28\u9178\u86cb\u767d\u9176\u6291\u5236\u5242\u8d85\u5bb6\u65cf\u6210\u5458\u4e4b\u4e00 \uff0c\u4e0e\u7cd6\u5c3f\u75c5 \u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u6709\u7740\u5bc6\u5207\u7684\u5173\u7cfb\uff0c\u5e38\u4f5c\u4e3a\u5fc3\u8840\u7ba1\u548c\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u5206\u5b50\u6807\u5fd7\u3002<\/p>\n\n\n\n

\u7ea4\u6eb6\u9176\u7cfb\u7edf\u548c\u5375\u5de2\u86cb\u767d\u7684\u52a8\u6001\u6c34\u89e3\u8fc7\u7a0b\u6709\u5173 \uff0c\u6709\u6570\u636e\u663e\u793aPCOS\u60a3\u8005\u8840\u6d46\u4e2d PAI-1 \u7684\u6c34\u5e73\u5347\u9ad8 \u3002Devin\u7b49\u5728\u5c0f\u9f20\u4e2d\u901a\u8fc7\u8fc7\u8868\u8fbe\u4eba PAI- 1\uff0c\u6784\u5efa \u4e86 PAI-1\u8f6c\u57fa\u56e0\u5c0f\u9f20\u3002\u5c0f\u9f20\u8868\u73b0 \u51fa\u8bb8\u591a PCOS\u60a3\u8005\u751f\u6b96\u65b9\u9762\u7684\u7279\u5f81 \uff0c\u5982 \uff1a\u4e0d\u6392\u5375 \u3001\u9ec4\u4f53\u7f3a\u5931 \uff0c\u800c\u4e14\u6709 50\uff05\u4ee5\u4e0a\u7684\u96cc\u9f20\u51fa\u73b0\u4e86\u5375\u5de2\u591a\u56ca\u5316\u3001\u5375\u5de2\u819c\u7ec6\u80de\u5c42\u589e\u539a \u3001\u9897\u7c92\u7ec6\u80de\u5c42\u53d8\u8584 \uff0c\u96c4\u6fc0\u7d20\u6c34\u5e73\u4e5f\u5347\u9ad8\u4e862 \u500d\u5de6\u53f3 (Devin\u7b49\uff0e2007)\u3002<\/p>\n\n\n\n

\u8fd9\u4e9b\u6570\u636e\u8868\u660e\u8fc7\u91cf PAI- 1\u53ef\u80fd\u53c2\u4e0e\u4e86 PCOS\u7684\u53d1\u751f\u53d1\u5c55 \uff0c\u7279\u522b\u662f\u5375\u5de2\u5f62\u6001\u548c\u529f\u80fd\u7684\u6539\u53d8 \uff0c\u4f46\u5c0f\u9f20\u4ee3\u8c22\u65b9\u9762\u7684\u53d8\u5316\u4e0d\u660e\u3002<\/p>\n\n\n\n

(\u516d )\u5375\u5de2\u8fc7\u8868\u8fbe\u795e\u7ecf\u751f\u957f\u56e0\u5b50 (nerve growth factor\uff0cNGF)\u7684\u5c0f\u9f20<\/strong><\/p>\n\n\n\n

\u4ea4\u611f\u795e\u7ecf\u5174\u594b\u6027\u589e\u5f3a\u88ab\u8ba4\u4e3a\u662f PCOS\u7684\u53d1\u75c5\u673a\u5236\u4e4b\u4e00 \uff0c\u80a5\u80d6 \u3001\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\u548c\u963b\u585e\u6027\u7761\u7720\u547c\u5438\u6682\u505c\u7b49 PCOS\u7684\u75c7\u72b6\u90fd\u4e0e\u4ea4\u611f\u795e\u7ecf\u8fc7\u5ea6\u5174\u594b\u6709\u5173 \u3002NGF\u662f\u4e00\u79cd\u795e\u7ecf\u8425\u517b\u56e0\u5b50 \uff0c\u80fd\u591f\u4fc3\u8fdb\u5375\u6ce1\u7684\u53d1\u80b2\u548c\u6392\u5375 \uff0c\u4e5f\u662f\u4ea4\u611f\u795e\u7ecf\u5174\u594b\u7684\u5206\u5b50\u6807\u5fd7\u4e4b\u4e00 \u3002\u5728PCOS\u60a3\u8005\u7684\u5375\u6ce1\u6d41\u51fa\u6db2\u548c\u4f53\u5916\u57f9\u517b\u7684 PCOS\u60a3\u8005\u539f\u4ee3\u9897\u7c92\u7ec6\u80de\u4e2d\u68c0\u6d4b\u51faNGF\u7684\u542b\u91cf\u9ad8\u4e8e\u6b63\u5e38\u5bf9\u7167\u7ec4 \u3002\u5c0f\u9f20\u5375\u5de2\u8fc7\u8868\u8fbeNGF\u53ef\u4ee5\u5bfc\u81f4\u5375\u6ce1\u5728\u7aa6\u6027\u5375\u6ce1\u671f\u51fa\u73b0\u95ed\u9501 \u3001\u51cb\u4ea1\u589e\u52a0\u3001\u5c0f\u7684\u751f\u957f\u5375\u6ce1\u79ef\u7d2f \uff0cLH\u6c34\u5e73\u6709\u8f7b\u5ea6\u7684\u6301\u7eed\u6027\u5347\u9ad8\uff0c\u8fd9\u4f7f\u5375\u5de2\u591a\u56ca\u5316\u7684\u51e0\u7387\u589e\u52a0 \uff0c\u8868 \u660ePCOS\u60a3\u8005\u7684\u5375\u5de2\u5f62\u6001\u53ef\u80fd\u4e0e\u5375\u5de2NGF\u7684\u542b\u91cf\u6709\u4e00\u5b9a\u5173\u7cfb\u00a8 \u3002\u540c\u65f6 \uff0c\u8fc7\u8868\u8fbe NGF\u7684\u5c0f\u9f20\u8fd8\u8868\u73b0\u51fa\u5bf9\u4fc3\u6027\u817a\u6fc0\u7d20\u7684\u9ad8\u53cd\u5e94\u6027 \u3001\u9752\u6625\u671f\u5ef6\u8fdf\u548c\u751f\u6b96\u80fd\u529b\u964d\u4f4e \u3002<\/p>\n\n\n\n

\u6700\u8fd1\uff0cWilson\u7b49\u5bf9\u8fd9\u79cd\u5375\u5de2\u8fc7\u8868\u8fbeNGF\u5c0f\u9f20(17NF\u5c0f\u9f20)\u7684\u4ee3\u8c22\u65b9\u9762\u8fdb\u884c\u4e86\u68c0\u6d4b \uff0c\u53d1\u73b017NF\u5c0f\u9f20\u5448\u73b0\u4f53\u91cd\u589e\u52a0\u3001\u8179\u90e8\u8102\u80aa\u76f8\u5bf9\u4e8e\u76ae\u4e0b\u8102\u80aa\u5206\u5e03\u589e\u52a0\u3001\u8461\u8404\u7cd6\u8010\u91cf\u5f02\u5e38\u548c\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\u7b49\u4ee3\u8c22\u5f02\u5e38\u75c7\u72b6\u3002\u8fd9\u4e9b\u7ed3\u679c\u63d0\u793a\u5375\u5de2\u8fc7\u8868\u8fbeNGF\u53ef\u4ee5\u8bf1\u5bfc\u51faPCOS\u7684\u751f\u6b96\u4e0e\u4ee3\u8c22\u65b9\u9762\u7684\u7279\u5f81 \uff0c \u540c\u65f6\u4e5f\u652f\u6301\u4e86\u4ea4\u611f\u795e\u7ecf\u8fc7\u5ea6\u5174\u594b\u662f\u5bfc\u81f4 PCOS\u53d1\u751f\u53d1\u5c55\u7684\u539f\u56e0\u4e4b\u4e00\u7684\u5047\u8bf4 \u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

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