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\u65b9\u6cd5<\/h3>\n\n\n\n

\u52a8\u7269<\/h4>\n\n\n\n

\u516d\u5468\u9f84 C57BL\/6J \u5c0f\u9f20\uff08277\u53ea\u96c4\u6027\u548c 278\u53ea\u96cc\u6027\uff09\uff0c\u4ece\u6770\u514b\u900a\u5b9e\u9a8c\u5ba4\u83b7\u5f97\uff0c\u5e76\u4ee55\u53ea\/\u7b3c\u7684\u5bc6\u5ea6\u4f7f\u7528\u6807\u51c6\u996e\u98df\u9972\u517b\u4e00\u5468\uff08 Teklad Global 16% \u86cb\u767d\u8d28\u556e\u9f7f\u52a8\u7269\u996e\u98df)\u3002\u968f\u540e\u5c06\u5c0f\u9f20\u5355\u72ec\u9972\u517b\u4e00\u5468\uff0c\u7136\u540e\u4ece 8 \u5468\u9f84\u5f00\u59cb\u5582\u98df HFD\uff08D12451\uff0c45% \u5343\u5361\u8102\u80aa\u548c 20% \u86cb\u767d\u8d28\u3002\u5c06 \u4e00\u4e2a\u6708\u524d\u83b7\u5f97\u7684\u53e6\u4e00\u7ec4 30 \u53ea\u76f8\u540c\u5e74\u9f84\u548c\u54c1\u7cfb\u7684\u5c0f\u9f20\uff0815\u53ea\u96c4\u6027\u548c15\u53ea\u96cc\u6027\uff09\u4f5c\u4e3a\u4f4e\u8102\u80aa\u5bf9\u7167\u7ec4\u3002 \u5728\u9002\u5e94\u4e00\u5468\u540e\uff0c\u8fd9 30 \u53ea\u5c0f\u9f20\u88ab\u5355\u72ec\u9972\u517b\uff0c\u968f\u540e\u4ece 8 \u5468\u9f84\u5f00\u59cb\u5582\u98df\u4f4e\u8102\u996e\u98df\uff08LFD\uff1bD12450B\uff0c10% \u5927\u5361\u8102\u80aa\u548c 20% \u5927\u5361\u86cb\u767d\u8d28\uff09\u3002<\/p>\n\n\n\n

\u6240\u6709\u5c0f\u9f20\u90fd\u9972\u517b\u5728\u5e26\u6709\u901a\u8fc7\u8fc7\u6ee4\u7cfb\u7edf\u7684\u6807\u51c6\u5c0f\u9f20\u7b3c\u4e2d\uff0c\u7b3c\u4e2d\u88c5\u6709 200 g \u706d\u83cc\u7684\u706d\u83cc\u5228\u82b1\u57ab\u6599\u548c\u548c\u538b\u7f29\u7eb8\u5377\u57ab\u6599\u3002\u9972\u517b\u5ba4\u662f\u4e00\u4e2a\u65e0\u7279\u5b9a\u75c5\u539f\u4f53\u7684\u52a8\u7269\u8bbe\u65bd\uff0c\u6709\u54e8\u5175\u76d1\u6d4b\u3002 \u6240\u6709\u7684\u7b3c\u5b50\u90fd\u4fdd\u6301\u5728\u901a\u98ce\u67b6\u7cfb\u7edf\u4e0a\u3002\u7b3c\u5177\u4e2d\u7684\u57ab\u6599\u548c\u6c34\uff0c\u6bcf\u6708\u66f4\u6362\u4e00\u6b21\uff0c\u7b3c\u5b50\u5728\u67b6\u5b50\u4e0a\u7684\u4f4d\u7f6e\u6bcf\u6708\u66f4\u6362\u4e00\u6b21\uff0c\u4ee5\u51cf\u5c11\u73af\u5883\u7684\u5f71\u54cd\uff08\u5149\u7167\u5f3a\u5ea6\u3001\u566a\u97f3\u3001\u632f\u52a8\u7b49\uff09\u3002 \u4ece\u65e9\u4e0a 6 \u70b9\u5f00\u59cb\uff0c\u52a8\u7269\u623f\u4fdd\u6301 12:12 \u5c0f\u65f6\u7684\u660e\u6697\u5faa\u73af\uff0c\u73af\u5883\u6e29\u5ea6\u4e3a 22\u00b11\u2103\uff0c\u6e7f\u5ea6\u4e3a 50%\u3002 \u6240\u6709\u7a0b\u5e8f\u5747\u6309\u7167\u963f\u62c9\u5df4\u9a6c\u5927\u5b66\u4f2f\u660e\u7ff0\u5206\u6821\u7684\u673a\u6784\u52a8\u7269\u62a4\u7406\u548c\u4f7f\u7528\u59d4\u5458\u4f1a (IACUC) \u6267\u884c\u3002<\/p>\n\n\n\n

\u63aa\u65bd<\/h4>\n\n\n\n

\u7b2c\u4e00\u4e2a\u6708\u6bcf\u5468\u6d4b\u91cf\u4f53\u91cd\uff0c\u6b64\u540e\u6bcf\u56db\u5468\u6d4b\u91cf\u4e00\u6b21\u4f53\u91cd\uff0c\u76f4\u5230 43 \u5468\u9f84\uff08\u9664\u975e\u7279\u6b8a\u6307\u5b9a\uff0c\u6240\u6709\u5468\u6570\u8868\u793a\u5c0f\u9f20\u5e74\u9f84\uff09\u3002 \u6bcf\u4e24\u5468\u66f4\u6362\u4e00\u6b21\u98df\u7269\uff0c\u6bcf\u4e24\u5468\u6d4b\u91cf\u4e00\u6b21\u3002 \u98df\u7269\u6444\u5165\u91cf\u662f\u901a\u8fc7\u4ece\u79f0\u91cd\u7684\u7b49\u5206\u8bd5\u6837\u4e2d\u51cf\u53bb\u5269\u4f59\u7684\u98df\u7269\uff08\u5305\u62ec\u7b3c\u4e2d\u4efb\u4f55\u6ea2\u51fa\u7684\u98df\u7269\uff09\u4e24\u5468\u65f6\u95f4\u6765\u83b7\u5f97\u7684\u3002 \u6839\u636e HFD \u7684 4.73 kcal\/g \u548c LFD \u7684 3.85 kcal\/g\uff08\u70ed\u91cf\u503c\u4ece\u7814\u7a76\u996e\u98df\u83b7\u5f97\uff09\u8ba1\u7b97\u80fd\u91cf\u6444\u5165\u3002 \u5982\u6240\u8ff0\uff0c\u5728 8\u300123 \u548c 43 \u5468\u9f84\u65f6\u4f7f\u7528\u5b9a\u91cf\u78c1\u5171\u632f (QMR) \u5728\u4f53\u5185\u6d4b\u5b9a\u8eab\u4f53\u6210\u5206\uff08\u8102\u80aa\u548c\u65e0\u8102\u80aa\u8d28\u91cf\uff09\u3002 \u4f53\u91cd\u53d8\u5316\u7684\u70ed\u91cf\u542b\u91cf\u8ba1\u7b97\u4e3a\u65e0\u8102\u80aa\u7ec4\u7ec7\u4e3a 1.8 kcal\/g\uff0c\u8102\u80aa\u7ec4\u7ec7\u4e3a 8 kcal\/g\u3002<\/p>\n\n\n\n

\u6839\u636e\u5927\u5b66\u548c IACUC \u7684\u653f\u7b56\uff0c\u5bf9\u6fd2\u6b7b\u7684\u5c0f\u9f20\uff0c\u5305\u62ec\u60a3\u6709\u6e83\u75a1\u6027\u76ae\u708e\u6216\u7c7b\u4f3c\u76ae\u80a4\u635f\u4f24\u7684\u5c0f\u9f20 (n=29) \u6216\u65e0\u6cd5\u8fdb\u98df\/\u996e\u6c34\u7684\u5c0f\u9f20\uff08\u4e00\u53ea\u96cc\u6027\uff09\u5b9e\u65bd\u5b89\u4e50\u6b7b\u3002 \u4e00\u53ea\u96c4\u6027\u5c0f\u9f20\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\u81ea\u53d1\u6b7b\u4ea1\u3002 \u5728 10 \u4e2a\u6708\u5927\u4e4b\u524d\uff0c\u5171\u6709 23 \u53ea\u96cc\u6027\u548c 8 \u53ea\u96c4\u6027\u5c0f\u9f20\u6b7b\u4ea1\u6216\u88ab\u79fb\u8d70\uff1b \u56e0\u6b64\uff0c554 \u53ea\u5c0f\u9f20\u88ab\u7eb3\u5165\u6570\u636e\u5206\u6790\uff08255 \u53ea HFD \u96cc\u6027\u3001269 \u53ea HFD \u96c4\u6027\u300115 \u53ea LFD \u96cc\u6027\u548c 15 \u53ea LFD \u96c4\u6027\uff09\u3002<\/p>\n\n\n\n

\u7edf\u8ba1\u5206\u6790<\/h4>\n\n\n\n

\u6240\u6709\u7edf\u8ba1\u5206\u6790\u5747\u4f7f\u7528 SAS\uff089.3 \u7248\uff1bSAS Institute\uff0cCary\uff0cNC\uff09\u8fdb\u884c\u3002 \u5b66\u751f t \u68c0\u9a8c\u6216\u91cd\u590d\u6d4b\u91cf\u65b9\u5dee\u5206\u6790\u548c Tukey-Kramer \u8c03\u6574\u7528\u4e8e\u591a\u91cd\u6bd4\u8f83\uff0c\u5728\u9002\u5f53\u7684\u60c5\u51b5\u4e0b\u7528\u4e8e\u786e\u5b9a\u4f53\u91cd\u3001\u98df\u7269\u6444\u5165\u91cf\u548c\u8eab\u4f53\u6210\u5206\u968f\u65f6\u95f4\u7684\u663e\u7740\u5dee\u5f02\u3002 \u91cd\u590d\u6d4b\u91cf\u534f\u65b9\u5dee\u5206\u6790\uff08ANCOVA\uff09\u7528\u4e8e\u6bd4\u8f83\u7ec4\u95f4\u4f53\u91cd\u7684\u53d8\u5316\u3002 \u4e3a\u4e86\u6bd4\u8f83\u4f53\u91cd\u548c\u4f53\u91cd\u589e\u52a0\uff0c\u6211\u4eec\u91c7\u7528\u4e09\u6b21\u591a\u9879\u5f0f\u6a21\u578b\u3002 \u65f6\u95f4\uff08\u5468\uff09\u662f\u4e00\u4e2a\u8fde\u7eed\u53d8\u91cf\uff0c\u6709\u5e73\u65b9\u9879\u548c\u7acb\u65b9\u9879\uff0c\u6a21\u578b\u5305\u62ec\u996e\u98df\u548c\u6027\u7684\u4e3b\u8981\u5f71\u54cd\uff0c\u4ee5\u53ca\u5b83\u4eec\u7684\u53cc\u5411\u4ea4\u4e92\u4f5c\u7528\u548c\u5b83\u4eec\u4e0e\u65f6\u95f4\u7684\u4ea4\u4e92\u4f5c\u7528\u3002 \u8fd9\u5141\u8bb8\u6bcf\u79cd\u996e\u98df\u548c\u6027\u522b\u7ec4\u5408\u5177\u6709\u660e\u663e\u7684\u4e09\u6b21\u751f\u957f\u66f2\u7ebf\uff0c\u5e76\u5141\u8bb8\u5728\u4e24\u79cd\u996e\u98df\u4e0d\u5e38\u89c1\u7684\u65f6\u95f4\u70b9\u8fdb\u884c\u6bd4\u8f83\u3002 \u91cd\u590d\u6d4b\u91cf\u4f7f\u7528\u7a7a\u95f4\u529f\u7387\u534f\u65b9\u5dee\u7ed3\u6784\u5efa\u6a21\uff0c\u56e0\u4e3a\u6d4b\u91cf\u662f\u5728\u4e0d\u76f8\u7b49\u7684\u65f6\u95f4\u95f4\u9694\u8fdb\u884c\u7684\u3002<\/p>\n\n\n\n

\u91c7\u7528\u975e\u53c2\u6570Mann-Whitney\u68c0\u9a8c\u5bf9\u4e0d\u540c\u6027\u522b\u7684\u4eba\u4f53\u6210\u5206\u8fdb\u884c\u6bd4\u8f83\u3002\u76ae\u5c14\u900a\u76f8\u5173\u88ab\u7528\u6765\u6d4b\u8bd5\u4f53\u91cd\u3001\u80fd\u91cf\u6444\u5165\u548c\u8eab\u4f53\u6210\u5206\u4e4b\u95f4\u7684\u76f8\u4e92\u5173\u7cfb\u3002\u591a\u53d8\u91cf\u65b9\u5dee\u5206\u6790\u7528\u4e8e\u9884\u6d4b\u6bcf\u79cd\u6027\u522b\u3001\u4f53\u91cd\u548c\u8102\u80aa\u8d28\u91cf\u968f\u65f6\u95f4\u7684\u53d8\u5316\uff0c\u4f53\u91cd\uff08\u6216\u8102\u80aa\u8d28\u91cf\uff09\u4f5c\u4e3a\u56e0\u53d8\u91cf\uff0c\u4e09\u4e2a\u57fa\u7ebf\u7279\u5f81\u4f5c\u4e3a\u81ea\u53d8\u91cf\u3002\u7edf\u8ba1\u663e\u8457\u6027\u6807\u51c6\u4e3aP<0.05\uff08\u53cc\u5c3e\uff09\uff0c\u4f7f\u7528\u7ecf\u591a\u91cd\u6bd4\u8f83\u8c03\u6574\u7684P\u503c\u3002<\/p>\n\n\n\n

\u7ed3\u679c<\/h3>\n\n\n\n

\u4f53\u91cd<\/h4>\n\n\n\n

\u4ece\u57fa\u7ebf\uff088 \u5468\u9f84\uff09\u5f00\u59cb\uff0cHFD \u548c LFD \u5c0f\u9f20\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u663e\u7740\u589e\u52a0\u4f53\u91cd\uff08all P < 0.0001\uff09\uff08\u56fe 1A\uff09\uff0c\u5177\u6709\u663e\u7740\u7684\u996e\u98df\u548c\u6027\u522b\u5f71\u54cd\u3002 \u4ece\u7b2c 8 \u5468\u5230\u7b2c 43 \u5468\uff0cHFD \u7537\u6027\u7684\u5e73\u5747\u4f53\u91cd\u589e\u52a0\u4e3a 20.53 \u514b\uff0cHFD \u5973\u6027\u4e3a 12.55 \u514b\uff0c\u800c LFD \u7537\u6027\u4e3a 10.5 \u514b\uff0cLFD \u5973\u6027\u4e3a 5.62 \u514b\u3002 \u5728\u6bcf\u79cd\u6027\u522b\u4e2d\uff0cHFD \u96c4\u6027\u5c0f\u9f20\u4ece\u7b2c 14 \u5468\u5f00\u59cb\u660e\u663e\u6bd4 LFD \u5c0f\u9f20\u91cd\uff08P = 0.0221\uff09\uff0c\u800c HFD \u96cc\u6027\u5c0f\u9f20\u5728\u7b2c 27 \u5468\u65f6\u4e0e LFD \u96cc\u6027\u5c0f\u9f20\u8868\u73b0\u51fa\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08P = 0.0076\uff09\u3002<\/p>\n\n\n\n

\u81f3\u4e8e\u4f53\u91cd\u7684\u589e\u52a0\uff08\u56fe 1B\uff09\uff0cHFD \u5582\u517b\u7684\u96c4\u6027\u548c\u96cc\u6027\u4e4b\u95f4\u7684\u663e\u7740\u5dee\u5f02\u5728\u7b2c 10 \u5468\u9996\u6b21\u660e\u663e\uff08P = 0.0027\uff09\u3002 \u4ece\u7b2c 14 \u5468\u5f00\u59cb\uff0cHFD \u96c4\u6027\u7684\u4f53\u91cd\u589e\u52a0\u4ecd\u7136\u663e\u7740\u5927\u4e8e LFD \u96c4\u6027\u548c\u4e24\u4e2a\u78c1\u6027\u7ec4\uff08\u7b2c 14 \u5468 HFD \u7537\u6027\u548c LFD \u7537\u6027\u4e4b\u95f4\u7684 P = 0.0028\uff1b\u6240\u6709\u5176\u4ed6 P < 0.0001\uff09\u3002 \u4ee5\u7c7b\u4f3c\u4e8e\u540c\u6027\u522b\u5185\u7684\u7edd\u5bf9\u4f53\u91cd\u6bd4\u8f83\u7684\u65b9\u5f0f\uff0cHFD \u7537\u6027\u7684\u4f53\u91cd\u53d8\u5316\u4ece\u7b2c 14 \u5468\u5f00\u59cb\u4e0e LFD \u7537\u6027\u6709\u663e\u7740\u5dee\u5f02\uff08P = 0.0028\uff09\uff0c\u4e4b\u540e\u4ecd\u7136\u5b58\u5728\u663e\u7740\u5dee\u5f02\uff08\u6240\u6709 P < 0.0001 \uff09\uff0c\u800c\u5973\u6027\u4ece\u7b2c 23 \u5468\u5f00\u59cb\uff08P = 0.0178\uff09\u5e76\u4fdd\u6301\u663e\u7740\u5dee\u5f02\uff08\u7b2c 27 \u5468 P = 0.0009\uff0c\u5176\u4f59\u5468 P < 0.0001\uff09\u3002 \u4e0e LFD \u7537\u6027\u548c HFD \u5973\u6027\u4e4b\u95f4\u7edd\u5bf9\u4f53\u91cd\u7684\u663e\u7740\u5dee\u5f02\uff08\u4ece\u7b2c 8 \u5468\u5230\u7b2c 39 \u5468\uff09\u76f8\u6bd4\uff0c\u8fd9\u4e24\u7ec4\u5728\u6240\u6709\u5468\u5185\u7684\u4f53\u91cd\u589e\u52a0\u5728\u7edf\u8ba1\u5b66\u4e0a\u76f8\u4f3c\u3002<\/p>\n\n\n\n

\"\"
\u56fe1 A<\/figcaption><\/figure>\n\n\n\n
\"\"
\u56fe1B<\/figcaption><\/figure>\n\n\n\n
\"\"
\u56fe 1C<\/figcaption><\/figure>\n\n\n\n

\u56fe1\uff1a\u4f53\u91cd\u548c\u80fd\u91cf\u6444\u5165\u91cf\u3002(A)\u4f53\u91cd\u968f\u65f6\u95f4\u53d8\u5316\u3002\u9ad8\u8102\u80aa\u996e\u98df\u7684\u96c4\u6027\u5c0f\u9f20\uff08HFDM\uff1b45%\u5343\u5361\u8102\u80aa\uff1bn=269\uff09\u3001\u4f4e\u8102\u996e\u98df\u7684\u96c4\u6027\u5c0f\u9f20\uff08LFDM\uff1b10%\u5343\u5361\u8102\u80aa\uff1bn=15\uff09\u3001\u9ad8\u8102\u996e\u98df\u7684\u96cc\u6027\u5c0f\u9f20\uff08HFDF\uff1bn=255\uff09\u548c\u4f4e\u8102\u996e\u98df\u7684\u96cc\u6027\u5c0f\u9f20\uff08LFDF\uff1bn=15\uff09\u3002(B)\u6240\u6709\u7ec4\u7684\u4f53\u91cd\u53d8\u5316\uff08\u6bcf\u5468\u7684\u4f53\u91cd\u51cf\u53bb\u57fa\u7ebf\u4f53\u91cd\uff09\u3002(C)\u5404\u7ec4\u60a3\u8005\u7684\u5e73\u5747\u6bcf\u65e5\u80fd\u91cf\u6444\u5165\u91cf\u968f\u65f6\u95f4\u800c\u53d8\u5316\u3002HFD\u7537\u6027\u548c\u5973\u6027\u7b2c18\u5468\u7684\u4f53\u91cd\u548c\u80fd\u91cf\u6444\u5165\u91cf\u4e3a\u7b2c17\u5468\u548c\u7b2c19\u5468\u7684\u5e73\u5747\u503c\uff0c\u4f7f\u5176\u4e0eLFD\u76f8\u5f53\u3002*\u8868\u793a\u5728\u7b2c10\u5468\u65f6\uff0cHFD\u5973\u6027\u548cHFD\u7537\u6027\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u6bcf\u4e2a\u65f6\u95f4\u70b9\u7684\u4e0d\u540c\u5b57\u6bcd\u8868\u793a\u5728P<\u4e3a0.05\u5904\u6709\u663e\u8457\u5dee\u5f02\u3002\u8bef\u5dee\u6761\u8868\u793aSE\u3002<\/p>\n\n\n\n

\u80fd\u91cf\u6444\u5165\u91cf<\/h4>\n\n\n\n

\u5728 HFD \u4e2d\uff0c\u7537\u6027\u7684\u80fd\u91cf\u6444\u5165\u660e\u663e\u9ad8\u4e8e\u5973\u6027\uff08\u6240\u6709\u5468 P < 0.0001\uff09\uff1b \u7136\u800c\uff0c\u5728 LFD \u4e2d\uff0c\u76f4\u5230\u7b2c 43 \u5468\u624d\u6709\u663e\u7740\u5dee\u5f02\uff08P=0.0103\uff09\u3002 HFD \u96c4\u6027\u548c\u96cc\u6027\u5c0f\u9f20\u80fd\u91cf\u6444\u5165\u7684\u6700\u7ec8\u6d4b\u91cf\u503c\u663e\u7740\u9ad8\u4e8e\u521d\u59cb\u6d4b\u91cf\u503c\uff08\u5747 P < 0.0001\uff09\uff0c\u4f46 LFD \u5c0f\u9f20\u6ca1\u6709\u663e\u7740\u5dee\u5f02\uff08\u96c4\u6027 P = 0.9494\uff0c\u96cc\u6027 P = 1.0000\uff09\u3002 HFD \u548c LFD \u52a8\u7269\u4e4b\u95f4\u6bcf\u65e5\u80fd\u91cf\u6444\u5165\u7684\u663e\u7740\u5dee\u5f02\u9996\u5148\u5728\u7b2c 27 \u5468\u7684\u96c4\u6027\u4e2d\u5f97\u5230\u8bc1\u5b9e\uff08P=0.0391\uff09\uff0c\u4f46\u5728\u7b2c 23 \u5468\uff08P=0.0091\uff09\u548c\u7b2c 43 \u5468\uff08P=0.0002\uff09\u518d\u6b21\u51fa\u73b0\u5728\u96cc\u6027\u4e2d\uff08P=0.0002\uff09\u3002 \u56fe 1C)\u3002<\/p>\n\n\n\n

\u6574\u4e2a\u7814\u7a76\u7684\u5e73\u5747\u6bcf\u65e5\u80fd\u91cf\u6444\u5165\u4e0e\u6240\u6709\u7ec4\u7684\u603b\u4f53\u91cd\u589e\u52a0\u663e\u7740\u76f8\u5173\uff08\u56fe 2A \u548c C\uff09\uff0c\u5e76\u4e14\u4e0e\u589e\u52a0\u7684\u4f53\u91cd\uff08\u8102\u80aa\u8d28\u91cf+\u65e0\u8102\u80aa\u8d28\u91cf\uff09\u7684\u70ed\u91cf\u542b\u91cf\u7c7b\u4f3c\u5730\u76f8\u5173\uff08\u56fe 2B \u548c D)\u3002 HFD \u5973\u6027\u7684\u5e73\u5747\u6bcf\u65e5\u80fd\u91cf\u6444\u5165\u4e0e\u603b\u4f53\u91cd\u589e\u52a0\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff08R=0.7268\uff0cP < 0.0001\uff09\u5f3a\u4e8e HFD \u7537\u6027\uff08R=0.3748\uff0cP < 0.0001\uff09\u3002 \u540c\u6837\uff0c\u5e73\u5747\u6bcf\u65e5\u80fd\u91cf\u6444\u5165\u91cf\u4e0e\u4f53\u91cd\u589e\u52a0\u7684\u70ed\u91cf\u542b\u91cf\u4e4b\u95f4\u5b58\u5728\u663e\u7740\u76f8\u5173\u6027\uff08HFD \u5973\u6027\u7684 R = 0.6989\uff0cP < 0.0001\uff1bHFD \u7537\u6027\u7684 R = 0.3377\uff0cP < 0.0001\uff09\u3002<\/p>\n\n\n\n

\u8eab\u4f53\u6784\u6210<\/h4>\n\n\n\n

\u9664\u4e86 LFD \u5973\u6027\u7684\u8102\u80aa\u91cf\uff08P=0.6597\uff09\uff08\u56fe 3A \u548c B\uff09\u5916\uff0c\u8102\u80aa\u91cf\u548c\u65e0\u8102\u80aa\u91cf\u5747\u968f\u65f6\u95f4\u663e\u7740\u589e\u52a0\uff08\u6240\u6709 P < 0.0001\uff09\u3002\u5728\u57fa\u7ebf\u65f6\uff0c\u65e0\u8bba\u662f HFD (P=1.0000) \u8fd8\u662f LFD (P=1.0000)\uff0c\u7537\u6027\u548c\u5973\u6027\u7684\u8102\u80aa\u91cf\u90fd\u6ca1\u6709\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u7136\u800c\uff0c\u5bf9\u4e8e HFD (P < 0.0001) \u548c LFD (P < 0.0001)\uff0c\u7537\u6027\u548c\u5973\u6027\u7684\u65e0\u8102\u80aa\u8d28\u91cf\u5b58\u5728\u663e\u7740\u5dee\u5f02\u3002\u5728\u7b2c 23 \u5468\u548c\u7b2c 43 \u5468\uff0c\u96c4\u6027\u6bd4\u96cc\u6027\u5177\u6709\u66f4\u5927\u7684\u65e0\u8102\u80aa\u8d28\u91cf\uff0c\u5e76\u4e14 HFD \u5c0f\u9f20\u6bd4 LFD \u5c0f\u9f20\u5177\u6709\u66f4\u5927\u7684\u8102\u80aa\u91cf\u3002\u5bf9\u4e8e\u7b2c 8 \u5468\u81f3\u7b2c 23 \u5468\u7684\u4f53\u91cd\u53d8\u5316\uff0c\u5728 HFD\uff0810.15 g \u5bf9 3.14 g\uff0cP < 0.0001\uff09\u548c LFD\uff084.36 g \u5bf9 0.98 g\uff0cP =0.0066);\u5728 HFD (P=0.9030) \u6216 LFD (Tukey-Kramer \u8c03\u6574\u540e P=1.000\uff0c\u672a\u8c03\u6574 P=0.9734) \u4e2d\uff0c\u7537\u6027\u548c\u5973\u6027\u5728\u65e0\u8102\u80aa\u8d28\u91cf\u53d8\u5316\u65b9\u9762\u6ca1\u6709\u663e\u7740\u5dee\u5f02\u3002\u5bf9\u4e8e\u7b2c 23 \u5468\u81f3\u7b2c 43 \u5468\u7684\u4f53\u91cd\u589e\u52a0\uff0cHFD \u7537\u6027\u548c\u5973\u6027\uff08P=0.9892\uff09\u6216 LFD \u7537\u6027\u548c\u5973\u6027\u4e4b\u95f4\uff08P=0.1986\uff09\u7684\u8102\u80aa\u91cf\u589e\u52a0\u6ca1\u6709\u663e\u7740\u5dee\u5f02\uff1b HFD \u7537\u6027\u548c\u5973\u6027\u4e4b\u95f4\u7684\u65e0\u8102\u80aa\u8d28\u91cf\u53d8\u5316\u6709\u663e\u7740\u5dee\u5f02\uff081.95 g \u5bf9 1.26 g\uff0cP < 0.0001\uff09\uff0c\u4f46 LFD \u7537\u6027\u548c\u5973\u6027\u4e4b\u95f4\u6ca1\u6709\u663e\u7740\u5dee\u5f02\uff08P = 0.8005\uff09\u3002<\/p>\n\n\n\n

\u867d\u7136\u65e0\u8102\u8d28\u91cf\u7684\u6570\u91cf\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u663e\u8457\u589e\u52a0\uff0c\u4f46\u56db\u7ec4\u7684\u65e0\u8102\u8d28\u91cf\u7684\u53d8\u5316\u90fd\u4fdd\u6301\u76f8\u5bf9\u7a33\u5b9a\u3002\u8fd9\u53ef\u4ee5\u4ece\u53d8\u5f02\u7cfb\u6570\u4e2d\u5f97\u5230\u8bc1\u660e\uff0c\u4ece\u7b2c43\u5468LFD\u7537\u6027\u76840.042\u5230\u7b2c8\u5468HFD\u5973\u6027\u76840.070\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u8102\u80aa\u8d28\u91cf\u7684\u53d8\u5f02\u6027\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u589e\u52a0\uff0c\u5728\u7b2c8\u5468\u65f6\u53d8\u5f02\u7cfb\u6570\u6700\u4f4e\uff0c\u4e3a0.138\uff0c\u5728\u7b2c43\u5468\u65f6\u6700\u9ad8\uff0c\u4e3a0.390\u3002\u8fd9\u4e00\u70b9\u5982\u56fe3C-E\u6240\u793a\u3002\u6240\u6709\u7ec4\u7684\u8102\u80aa\u8d28\u91cf\u548c\u65e0\u8102\u80aa\u8d28\u91cf\u57288\u300123\u548c43\u7684\u5206\u5e03\u5982\u56fe4\u6240\u793a\u3002\u5982\u56fe4E\u548cF\uff0c\u7537\u6027\u548c\u5973\u6027\u7684\u8102\u80aa\u8d28\u91cf\u663e\u8457\u589e\u52a0\u7684\u53d8\u5316(P<0.0001)\uff0c\u4f46\u65e0\u8102\u80aa\u8d28\u91cf\u7684\u65b9\u5dee\u6ca1\u6709\u663e\u8457\u53d8\u5316\uff0c\u9664\u4e86HFD\u7537\u6027\u4ece23\u5468\u523043\u5468(P<0.0001)\u3002\u5bf9\u4e8eLFD\u5c0f\u9f20\uff0c\u8102\u80aa\u8d28\u91cf\u548c\u65e0\u8102\u80aa\u8d28\u91cf\u90fd\u6ca1\u6709\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u589e\u52a0\uff0c\u9664\u4e86LFD\u96c4\u6027\u7684\u8102\u80aa\u8d28\u91cf\u5dee\u5f02\uff0c\u4ece\u7b2c8\u5468\u5230\u7b2c23\u5468\u663e\u8457\u589e\u52a0(P<0.0001)\u3002<\/p>\n\n\n\n

\u652f\u6301\u4fe1\u606f \u56fe 2 \u8bf4\u660e\u4e86\u4ece\u57fa\u7ebf\uff08\u7b2c 8 \u5468\uff09\u5230\u7814\u7a76\u7ed3\u675f\uff08\u7b2c 43 \u5468\uff09\u4f53\u91cd\u589e\u52a0\u4e0e\u8102\u80aa\u91cf\u548c\u65e0\u8102\u80aa\u91cf\u589e\u52a0\u4e4b\u95f4\u7684\u5173\u7cfb\u3002 \u5bf9\u4e8e HFD \u7537\u6027 (R=0.9692, P < 0.0001)\u3001LFD \u7537\u6027 (R=0.9349, P < 0.0001) \u548c HFD \u5973\u6027 (R = 0.9791\uff0cP < 0.0001\uff09\u4f46\u4e0d\u9002\u7528\u4e8e LFD \u5973\u6027\uff08R = 0.3901\uff0cP = 0.1506\uff09\u3002 \u540c\u6837\uff0c\u4f46\u5728\u8f83\u5c0f\u7a0b\u5ea6\u4e0a\uff0c\u65e0\u8102\u80aa\u8d28\u91cf\u589e\u52a0\uff08D \u65e0\u8102\u80aa\u8d28\u91cf\uff09\u4e5f\u4e0e HFD \u7537\u6027\uff08R = 0.7456\uff0cP < 0.0001\uff09\u3001HFD \u5973\u6027\uff08R = 0.5294\uff0cP < 0.0001\uff09\u7684 D \u4f53\u91cd\u663e\u7740\u76f8\u5173 )\uff0c\u548c LFD \u5973\u6027 (R=0.6822, P=0.0051) \u4f46\u4e0d\u662f LFD \u7537\u6027 (R=0.5074, P=0.0535)\u3002 \u6b64\u5916\uff0c\u5728\u5927\u591a\u6570\u65f6\u95f4\u70b9\uff0c\u6240\u6709\u56db\u7ec4\u7684\u7edd\u5bf9\u8102\u80aa\u91cf\u548c\u65e0\u8102\u80aa\u91cf\u4e4b\u95f4\u5b58\u5728\u663e\u7740\u76f8\u5173\u6027\uff08\u652f\u6301\u4fe1\u606f\u8868 1\uff09\u3002<\/p>\n\n\n\n

\"\"
\u56fe2<\/figcaption><\/figure>\n\n\n\n

\u56fe2\u80fd\u91cf\u6444\u5165\u4e0e\u603b\u4f53\u91cd\u589e\u52a0\u6216\u4f53\u91cd\u589e\u52a0\u7684\u70ed\u91cf\u542b\u91cf\u7684\u76f8\u5173\u6027\u3002(A)HFD\u7537\u6027\u548cLFD\u7537\u6027\u7684\u5e73\u5747\u6bcf\u65e5\u80fd\u91cf\u6444\u5165\u548c\u603b\u4f53\u91cd\u589e\u52a0\u548c\u4f53\u91cd\u589e\u52a0\u7684(B)\u70ed\u91cf\u542b\u91cf\uff1b(C)HFD\u5973\u6027\u548cLFD\u5973\u6027\u7684\u5e73\u5747\u6bcf\u65e5\u80fd\u91cf\u6444\u5165\u548c\u603b\u4f53\u91cd\u589e\u52a0\u4ee5\u53ca\u4f53\u91cd\u589e\u52a0\u7684(D)\u70ed\u91cf\u542b\u91cf<\/p>\n\n\n\n

\u5bf9HFD\u5c0f\u9f20\u4f53\u91cd\uff08\u589e\u91cd\uff09\u9884\u6d4b\u7684\u591a\u53d8\u91cf\u65b9\u5dee\u5206\u6790<\/h4>\n\n\n\n

\u8003\u8651\u5230\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\u89c2\u5bdf\u5230\u7684\u6700\u7ec8\u4f53\u91cd\uff08\u548c\u8102\u80aa\u8d28\u91cf\uff09\u7684\u5de8\u5927\u53d8\u5f02\u6027\uff0c\u6211\u4eec\u5c06\u8102\u80aa\u8d28\u91cf\u3001\u65e0\u8102\u80aa\u8d28\u91cf\u548c\u5e73\u5747\u6bcf\u65e5\u80fd\u91cf\u6444\u5165\u7684\u57fa\u7ebf\u503c\u4f5c\u4e3aDIO\u53cd\u5e94\u7684\u9884\u6d4b\u56e0\u7d20\uff08\u6216\u89e3\u91ca\u53d8\u91cf\uff09\u3002\u4f53\u91cd\u9884\u6d4b\u7684\u591a\u53d8\u91cf\u65b9\u5dee\u5206\u6790\uff08\u88681\uff09\u8868\u660e\uff0c\u8fd9\u4e9b\u57fa\u7ebf\u6d4b\u91cf\u5bf9\u9884\u6d4b\u672a\u6765\u4f53\u91cd\u5177\u6709\u663e\u8457\u6027\uff0c\u4f46\u5176\u663e\u8457\u6027\u5177\u6709\u6027\u522b\u7279\u5f02\u6027\u3002<\/p>\n\n\n\n

\u5728HFD\u96c4\u6027\u5c0f\u9f20\u672a\u6765\u4f53\u91cd\u7684\u8fd9\u4e09\u4e2a\u9884\u6d4b\u56e0\u5b50\u4e2d\uff0c\u5b83\u4eec\u5728\u6574\u4e2a\u7814\u7a76\u8fc7\u7a0b\u4e2d\u90fd\u662f\u672a\u6765\u4f53\u91cd\u7684\u663e\u8457\u9633\u6027\u9884\u6d4b\u56e0\u5b50(\u6240\u6709\u603b\u4f53\u6548\u5e94P<0.0001)\u3002\u5bf9\u4e8eHFD\u96cc\u6027\u5c0f\u9f20\uff0c\u57fa\u7ebf\u8102\u80aa\u8d28\u91cf\u548c\u65e0\u8102\u80aa\u8d28\u91cf\u662f\u6240\u6709\u65f6\u95f4\u70b9\u7684\u663e\u8457\u9884\u6d4b\u56e0\u5b50(\u603b\u4f53\u6548\u5e94P<0.0001)\uff1b\u57fa\u7ebf\u80fd\u91cf\u6444\u5165\u5728\u7b2c35\u5468\u662f\u4e00\u4e2a\u663e\u8457\u7684\u9884\u6d4b\u56e0\u5b50(\u5728\u7b2c35\u5468\u662fP5 0.0477 )\u3002<\/p>\n\n\n\n

\u5bf9\u4e8e\u8102\u80aa\u8d28\u91cf\u7684\u9884\u6d4b\uff08\u88682\uff09\uff0c\u57fa\u7ebf\u8102\u80aa\u8d28\u91cf\u5bf9\u4e24\u6027\u90fd\u662f\u4e00\u4e2a\u663e\u8457\u7684\u9884\u6d4b\u56e0\u5b50(\u603b\u4f53\u6548\u5e94P<0.0001)\u3002\u57fa\u7ebf\u65e0\u8102\u80aa\u5bf9HFD\u5973\u6027\u7684\u4e24\u79cd\u672a\u6765\u6d4b\u91cf\u90fd\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u9884\u6d4b\u56e0\u7d20\uff0c\u4f46\u4ec5\u5bf9HFD\u7537\u6027\u5728\u7b2c23\u5468\u7684\u6d4b\u91cf\u5177\u6709\u663e\u8457\u6027\u3002\u57fa\u7ebf\u80fd\u91cf\u6444\u5165\u4ec5\u5728HFD\u7537\u6027\u7b2c23\u5468(P<0.0001)\u548cHFD\u5973\u6027(P5 0.0054)\u662f\u4e00\u4e2a\u663e\u8457\u7684\u9884\u6d4b\u56e0\u5b50\u3002<\/p>\n\n\n\n

\"\"
\u56fe 3<\/figcaption><\/figure>\n\n\n\n

\u56fe3\uff1a\u8eab\u4f53\u6210\u5206\u7684\u53d8\u5316\u3002(A)\u6240\u6709\u7ec4\u7684\u8102\u80aa\u8d28\u91cf(\u5e73\u5747SE)\uff1b\u6240\u6709\u7ec4\u7684(B)\u65e0\u8102\u80aa\u8d28\u91cf(\u5e73\u5747SE)\uff1b\u5728(C)\u7b2c8\u5468\u3001(D)\u7b2c23\u5468\u548c(E)\u7b2c43\u5468\u65f6\uff0c\u6240\u6709\u7ec4\u7684\u8eab\u4f53\u7ec4\u6210\uff08\u8102\u80aa\u8d28\u91cf\u4e0e\u65e0\u8102\u80aa\u8d28\u91cf\uff09\u5206\u6563\u3002\u4e0d\u540c\u5b57\u6bcd\u8868\u793aP<0.05\u6709\u663e\u8457\u5dee\u5f02\u3002<\/p>\n\n\n\n

\u8ba8\u8bba<\/h3>\n\n\n\n

\u672c\u7814\u7a76\u4e2d\u63d0\u4f9b\u7684\u6570\u636e\u6765\u81ea\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u7684\u957f\u5bff\u7814\u7a76\u7684DIO\u9636\u6bb5\uff0c\u8be5\u7814\u7a76\u4f7f\u7528\u7684\u662f\u6709\u80a5\u80d6\u503e\u5411\u7684C57BL\/B6J\u5c0f\u9f20\u3002\u6240\u7528\u996e\u98df\u4e2d\u7684\u8102\u80aa\u542b\u91cf\u4e0e\u7f8e\u56fd\u4eba\u53e3\uff0812,13\uff09\u4e2d\u7684\u8102\u80aa\u6444\u5165\u91cf\u76f8\u4f3c\u3002\u867d\u7136\u5927\u591a\u6570\u5df2\u53d1\u8868\u7684\u5173\u4e8eC57BL\/6\u5c0f\u9f20\u4e2dDIO\u7684\u6587\u732e\u53ea\u5173\u6ce8\u96c4\u6027\uff0c\u4f46\u6211\u4eec\u4f7f\u7528\u4e86\u4e24\u6027\u3002\u4e0e\u5176\u4ed6\u7814\u7a76\uff086,16\uff09\u4e00\u81f4\uff0c\u6211\u4eec\u7684\u7ed3\u679c\u663e\u793a\uff0c\u96c4\u6027C57BL\/6J\u5c0f\u9f20\u5bf9DIO\u654f\u611f\uff0c\u800c\u96cc\u6027\u5c0f\u9f20\u7684\u654f\u611f\u7a0b\u5ea6\u8f83\u8f7b\uff0c\u4e14\u901f\u5ea6\u8f83\u6162\u3002\u6b64\u5916\uff0c\u5728\u4f53\u91cd\u7684\u53d8\u5316\u548c\u5206\u5e03\u3001\u80fd\u91cf\u8f6c\u6362\u4e3a\u4f53\u91cd\u548c\u8eab\u4f53\u7ec4\u6210\u7684\u53d8\u5316\u4ee5\u53ca\u5177\u6709\u57fa\u7ebf\u7279\u5f81\u7684\u4f53\u91cd\u9884\u6d4b\u7b49\u65b9\u9762\u4e5f\u5b58\u5728\u6027\u522b\u5dee\u5f02\u3002<\/p>\n\n\n\n

\"\"
\u56fe4<\/figcaption><\/figure>\n\n\n\n

\u56fe4 \u7b2c8\u5468\u3001\u7b2c23\u5468\u3001\u7b2c43\u5468\u7684\u4f53\u6210\u5206\u5206\u5e03\u3002\u76f4\u65b9\u56fe\u5206\u5e03(\u752830\u4e2a\u7bb1\u5b50\u7ed8\u5236\uff0c\u8102\u80aa\u8d28\u91cf\u4e3a0\u523030g\uff0c\u65e0\u8102\u80aa\u8d28\u91cf\u4e3a10\u523030g)\u3002(A)HFD\u7537\u6027\u8102\u80aa\u8d28\u91cf\uff1bHFD\u5973\u6027(B)\u8102\u80aa\u8d28\u91cf\uff1bHFD\u7537\u6027(C)\u65e0\u8102\u80aa\u8d28\u91cf\uff1bHFD\u5973\u6027(D)\u65e0\u8102\u80aa\u8d28\u91cf\u3002(E\uff09\u6240\u6709\u7ec4\u7684\u8102\u80aa\u8d28\u91cf\u548c(F\uff09\u6240\u6709\u7ec4\u7684\u65e0\u8102\u80aa\u8d28\u91cf\u7684\u4e2a\u4f53\u6563\u70b9\u56fe\u5206\u5e03\u3002<\/p>\n\n\n\n

\u96c4\u6027 C57BL\/6 \u5c0f\u9f20\u4e00\u76f4\u662f\u7528\u4e8e DIO \u7814\u7a76\u7684\u6807\u51c6\u52a8\u7269 (1-4)\uff0c\u4f46\u5f88\u5c11\u6709\u7814\u7a76\u62a5\u544a\u96cc\u6027 C57BL\/6 \u5bf9\u9ad8\u8102\u80aa DIO \u7684\u53cd\u5e94\uff0c\u5176\u5c40\u9650\u6027\u5305\u62ec\u6837\u672c\u91cf\u5c0f\u6216\u7814\u7a76\u6301\u7eed\u65f6\u95f4\u77ed\u3002 Tortoriello \u7b49\u4eba (17,18) \u8bc1\u660e\u5728 C57BL\/6J \u54c1\u7cfb\u4e2d\u5b58\u5728\u660e\u663e\u7684\u96cc\u6027\u5bf9 DIO \u7684\u6027\u522b\u7279\u5f02\u6027\u6297\u6027\uff0c\u5176\u4e2d 24% kcal \u8102\u80aa\u996e\u98df\u6301\u7eed 20 \u5468 (n=20) \u548c 35% \u8102\u80aa\u996e\u98df\u6301\u7eed 24 \u5468 (n=10) \u548c\u63a8\u6d4b\u5ef6\u957f\u5582\u517b\u6216\u9ad8\u8102\u80aa\u996e\u98df\u53ef\u80fd\u66f4\u6709\u6548\u3002\u540e\u6765\u7684\u4e00\u9879\u7814\u7a76 (11) \u53d1\u73b0\uff0c\u996e\u98df\u4e2d\u8102\u80aa\u542b\u91cf\u8d8a\u9ad8\uff0c\u4f53\u91cd\u8d8a\u9ad8\uff0c\u6211\u4eec\u89c2\u5bdf\u523045%\u5927\u5361\u8102\u80aa\u996e\u98df12\u5468\uff08n=50\uff09\u4f53\u91cd\u589e\u52a024%\uff0c\u8102\u80aa\u542b\u91cf\u66f4\u9ad8\uff0860%\uff09\u65f6\u4f53\u91cd\u589e\u52a039%\uff0c\u8be5\u7814\u7a76\u4e0d\u652f\u6301\u6027\u522b\u7279\u5f02\u6027\u80a5\u80d6\u62b5\u6297\u7684\u6982\u5ff5\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u5728\u9ad8\u8102\u5582\u517b 35 \u5468\u540e\uff0c\u6211\u4eec\u7684 HFD\u96cc\u6027\u5c0f\u9f20(n = 255) \u4f53\u91cd\u5e73\u5747\u589e\u52a0\u4e86 71%\uff0c\u800c\u96c4\u6027\u5c0f\u9f20 (n = 269) \u589e\u52a0\u4e86 93%\u3002\u5728\u6700\u7ec8\u4f53\u91cd\u5206\u5e03\u4e2d\uff0c\u96c4\u6027\u504f\u5de6\uff08\u504f\u5ea6=20.284\uff09\uff0c\u800c\u96cc\u6027\u504f\u53f3\uff08\u504f\u5ea6= 0.659\uff09\u3002\u8fd9\u8868\u660e\u5c0f\u90e8\u5206\u96cc\u6027\u5c0f\u9f20\u666e\u904d\u503e\u5411\u4e8e\u5927\u5927\u8d85\u8fc7\u5176\u9884\u671f\u4f53\u91cd\u589e\u52a0\uff0c\u800c\u4e00\u5c0f\u90e8\u5206\u96c4\u6027\u5c0f\u9f20\u672a\u8fbe\u5230\u9884\u671f\u4f53\u91cd\u589e\u52a0\u3002\u5f53\u96c4\u6027\u548c\u96cc\u6027\u5c0f\u9f20\u5582\u98df HFD \u548c LFD \u65f6\uff0c\u96c4\u6027\u5c0f\u9f20\u6bd4\u96cc\u6027\u66f4\u65e9\u89c2\u5bdf\u5230\u4e24\u79cd\u996e\u98df\u4e4b\u95f4\u7684\u663e\u7740\u5dee\u5f02\uff0c\u8fd9\u8868\u660e\u96c4\u6027\u5bf9 HFD \u7684\u53cd\u5e94\u6bd4\u96cc\u6027\u66f4\u5feb\u3002\u5176\u4ed6\u996e\u98df\u76f8\u540c\u6216\u76f8\u4f3c\u7684\u4eba (6,19) \u4e5f\u89c2\u5bdf\u5230\u7537\u6027 HFD \u548c LFD \u4e4b\u95f4\u4f53\u91cd\u7684\u65e9\u671f\u5dee\u5f02\u3002\u96cc\u6fc0\u7d20\u6c34\u5e73 (20)\u3001\u6027\u522b\u7279\u5f02\u6027\u7626\u7d20\u62b5\u6297 (4,21) \u548c\u603b\u4f53\u8fd0\u52a8\u6d3b\u52a8\u7684\u5dee\u5f02 (16) \u53ef\u80fd\u5bfc\u81f4\u5bf9 DIO \u7684\u53cd\u5e94\u5b58\u5728\u6027\u522b\u5dee\u5f02\uff0c\u4f46\u5728\u672c\u7814\u7a76\u4e2d\u672a\u5bf9\u5b83\u4eec\u8fdb\u884c\u6d4b\u8bd5\u3002<\/p>\n\n\n\n

\u6211\u4eec\u53d1\u73b0\uff0c\u5728\u957f\u671f HFD \u5582\u517b\u540e\uff0c\u52a8\u7269\u7684\u4f53\u91cd\u548c\u8102\u80aa\u91cf\u5dee\u5f02\u5f88\u5927\uff0c\u8fd9\u4e0e\u5176\u4ed6\u7814\u7a76\u7684\u7ed3\u679c\u4e00\u81f4 (8,9,11,22)\u3002\u968f\u7740\u5c0f\u9f20\u53d8\u5927\uff0c\u96c4\u6027\u548c\u96cc\u6027\u7684\u8102\u80aa\u91cf\u53d8\u5316\u5927\u4e8e\u65e0\u8102\u91cf\u7684\u53d8\u5316\uff0c\u8fd9\u8868\u660e\u65e0\u8102\u91cf\u53d7\u996e\u98df\u63a7\u5236\u7684\u5f71\u54cd\u6bd4\u8102\u80aa\u91cf\u5c0f\u3002\u786e\u5b9a\u4f53\u91cd\u6216\u8102\u80aa\u91cf\u53d8\u5316\u4f55\u65f6\u53d1\u751f\u589e\u52a0\u4ee5\u53ca\u662f\u4ec0\u4e48\u5bfc\u81f4\u8fd9\u79cd\u9057\u4f20\u4e0a\u76f8\u540c\u7684\u8fd1\u4ea4\u7cfb\u5c0f\u9f20\u54c1\u7cfb\u7684\u53d8\u5316\u975e\u5e38\u91cd\u8981\u3002\u79d1\u624e\u7b49\u4eba (9) \u8868\u660e\uff0c\u5373\u4f7f\u5728 LFD \u5582\u517b\u6570\u5468\u540e\uff0c\u4f53\u91cd\u7684\u53d8\u5316\u4e5f\u53d1\u751f\u5728\u5e7c\u5e74\u7684\u65f6\u5019\uff0c\u5e76\u4e14\u8fd9\u79cd\u53d8\u5316\u5728\u70ed\u91cf\u9650\u5236\u7684\u60c5\u51b5\u4e0b\u4ecd\u7136\u5b58\u5728\u3002\u6211\u4eec\u901a\u8fc7\u5206\u522b\u5206\u6790\u5728\u6240\u6709\u540c\u6027 HFD \u52a8\u7269\u7684\u524d 10% \u6216\u540e 10% \u4e2d\u5b8c\u6210\u7814\u7a76\u7684 HFD \u52a8\u7269\u6765\u68c0\u9a8c\u8fd9\u4e00\u73b0\u8c61\u3002\u5728\u57fa\u7ebf\u65f6\uff0c\u96c4\u6027\u5c0f\u9f20 (P < 0.0001) \u548c\u96cc\u6027\u5c0f\u9f20 (P < 0.0001) \u4e4b\u95f4\u5b58\u5728\u663e\u7740\u5dee\u5f02\uff08\u652f\u6301\u4fe1\u606f\u56fe 1A \u548c B\uff09\uff0c\u8fd9\u8868\u660e\u5728\u63a5\u53d7 HFD \u4e4b\u524d\u5df2\u7ecf\u5b58\u5728\u4f53\u91cd\u53d8\u5316\u3002\u6b64\u5916\uff0c\u5373\u4f7f\u5728 HFD \u5582\u517b\u4e0b\uff0c\u5e95\u90e8 10% HFD \u5c0f\u9f20\uff08\u96c4\u6027\u548c\u96cc\u6027\uff09\u7684\u4f53\u91cd\u5728\u5927\u591a\u6570\u65f6\u95f4\u70b9\u4e0e LFD \u5c0f\u9f20\u7684\u4f53\u91cd\u6ca1\u6709\u663e\u7740\u5dee\u5f02\u3002<\/p>\n\n\n\n

\"\"
\u652f\u6301\u4fe1\u606f\u56fe1<\/figcaption><\/figure>\n\n\n\n

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