{"id":176,"date":"2025-06-18T02:50:46","date_gmt":"2025-06-17T18:50:46","guid":{"rendered":"http:\/\/www.leishidiet.com\/?p=176"},"modified":"2025-06-19T02:50:50","modified_gmt":"2025-06-18T18:50:50","slug":"%e5%8a%a8%e8%84%89%e7%b2%a5%e6%a0%b7%e7%a1%ac%e5%8c%96%e5%8a%a8%e7%89%a9%e6%a8%a1%e5%9e%8b%e7%bb%bc%e8%bf%b0","status":"publish","type":"post","link":"https:\/\/www.leishidiet.com\/?p=176","title":{"rendered":"\u52a8\u8109\u7ca5\u6837\u786c\u5316\u52a8\u7269\u6a21\u578b\u7efc\u8ff0"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u6458\u8981<\/h2>\n\n\n\n<p>\u7406\u60f3\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u52a8\u7269\u6a21\u578b\uff0c\u5e94\u8be5\u662f\u5177\u6709\u7c7b\u4f3c\u4e8e\u4eba\u4f53\u89e3\u5256\u5b66\u548c\u75c5\u7406\u751f\u7406\u5b66\u7684\u75c5\u53d8\u72b6\u6001\uff0c\u5e76\u6709\u53ef\u80fd\u7528\u4e8e\u533b\u5b66\u548c\u836f\u7269\u7814\u7a76\uff0c\u4ee5\u83b7\u5f97\u53ef\u5916\u63a8\u5230\u4eba\u7c7b\u533b\u5b66\u7684\u7ed3\u679c\u3002\u6b64\u5916\uff0c\u5b83\u5fc5\u987b\u6613\u4e8e\u83b7\u53d6\uff0c\u53ef\u4ee5\u4ee5\u5408\u7406\u7684\u6210\u672c\u8fdb\u884c\u7ef4\u62a4\uff0c\u6613\u4e8e\u5904\u7406\uff0c\u5e76\u4e0e\u4eba\u7c7b\u6709\u5c3d\u53ef\u80fd\u7c7b\u4f3c\u7684\u75c5\u7406\u72b6\u6001\u3002<\/p>\n\n\n\n<p>\u4e00\u822c\u6765\u8bf4\uff0c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u52a8\u7269\u6a21\u578b\u662f\u57fa\u4e8e\u8fd9\u4e9b\u56e0\u7d20\u5efa\u7acb\u7684\uff1a\u5bcc\u542b\u80c6\u56fa\u9187\/\u897f\u5f0f\u996e\u98df\u5bfc\u81f4\u7684\u52a0\u901f\u6591\u5757\u5f62\u6210\u3001\u5bf9\u53c2\u4e0e\u80c6\u56fa\u9187\u4ee3\u8c22\u7684\u57fa\u56e0\u7684\u8c03\u63a7\u7eb5\u4ee5\u53ca\u5f15\u5165\u8bf1\u53d1\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5176\u4ed6\u5371\u9669\u56e0\u7d20\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.shuyudiet.com\/tag\/14\">\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6a21\u578b<\/a>\u4e3b\u8981\u4f7f\u7528\u5c0f\u9f20\u548c\u5154\u5b50\u6a21\u578b\uff0c\u5176\u6b21\u662f\u732a\u548c\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u3002\u8fd9\u4e9b\u6a21\u578b\u4e2d\u7684\u6bcf\u4e00\u4e2a\u90fd\u6709\u5176\u4f18\u70b9\u548c\u5c40\u9650\u6027\u3002<\/p>\n\n\n\n<p>\u5c0f\u9f20\u5df2\u6210\u4e3a\u7814\u7a76\u5b9e\u9a8c\u6027\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u4e3b\u8981\u7269\u79cd\uff0c\u5f52\u7ed3\u4e8e\u5176\u5feb\u901f\u7e41\u6b96\u3001\u6613\u4e8e\u9057\u4f20\u64cd\u4f5c\u4ee5\u53ca\u5728\u5408\u7406\u7684\u65f6\u95f4\u8303\u56f4\u5185\u76d1\u6d4b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5f62\u6210\u7684\u80fd\u529b\u3002\u8f7d\u8102\u86cb\u767dE\u7f3a\u9677\u578b (ApoE<sup>-\/-<\/sup>&nbsp;) \u548c LDL \u53d7\u4f53 (LDLr) \u6572\u9664\u5c0f\u9f20\u90fd\u7ecf\u5e38\u4f7f\u7528\uff0c\u800c\u4e14 ApoE\/LDLr \u53cc\u6572\u9664\u5c0f\u9f20\u3001ApoE3-Leiden \u548c PCSK9-AAV \u5c0f\u9f20\u4e5f\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7814\u7a76\u7684\u91cd\u8981\u5de5\u5177\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u5f00\u53d1\u6591\u5757\u5185\u5fae\u8840\u7ba1\u3001\u51fa\u8840\u3001\u81ea\u53d1\u6027\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7834\u88c2\u3001\u5fc3\u808c\u6897\u6b7b\u548c\u731d\u6b7b\u9636\u68af\u5f0f\u8fde\u7eed\u53d1\u751f\u7684\u6a21\u578b\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\u3002\u8fd9\u4e9b\u7279\u5f81\u5b58\u5728\u4e8e&nbsp;ApoE<sup>-\/-<\/sup>Fbn1<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u4e2d\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u6709\u6548\u6a21\u578b\u6765\u8bc4\u4ef7\u65b0\u578b\u6591\u5757\u7a33\u5b9a\u836f\u7269\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sect0015\">1&nbsp;.&nbsp;\u4ecb\u7ecd<\/h2>\n\n\n\n<p id=\"p0120\">\u52a8\u8109\u7ca5\u6837\u786c\u5316\u662f\u4e00\u79cd\u8fdb\u884c\u6027\u708e\u75c7\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u5728\u4e8e\u52a8\u8109\u8840\u7ba1\u58c1\u4e2d\u8102\u8d28\u7684\u79ef\u7d2f\uff0c\u8fd9\u79cd\u75be\u75c5\u5728\u751f\u547d\u65e9\u671f\u5c31\u5f00\u59cb\u4e86\u3002\u75be\u75c5\u8fdb\u5c55\u5bfc\u81f4\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7684\u79ef\u805a\uff0c\u4ece\u800c\u5bfc\u81f4\u52a8\u8109\u7ba1\u8154\u53d8\u7a84\u3002\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u901a\u5e38\u4fdd\u6301\u7a33\u5b9a\u591a\u5e74\uff0c\u4f46\u4f1a\u8fc5\u901f\u53d8\u5f97\u4e0d\u7a33\u5b9a\u3001\u7834\u88c2\u5e76\u5f15\u53d1\u8840\u6813\u5f62\u6210\u3002\u56e0\u6b64\uff0c\u9664\u4e86\u9650\u5236\u8840\u7ba1\u8154\uff0c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7684\u5b58\u5728\u4e0e\u6025\u6027\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u5982\u5fc3\u808c\u6897\u6b7b(MI)\u548c\u4e2d\u98ce\u7684\u98ce\u9669\u589e\u52a0\u6709\u5173\u3002\u52a8\u8109\u7ca5\u6837\u786c\u5316\u52a8\u7269\u6a21\u578b\u7684\u4f7f\u7528\u662f\u63d0\u9ad8\u5bf9\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u5f62\u6210\u548c\u8fdb\u5c55\u80cc\u540e\u7684\u5206\u5b50\u673a\u5236\u4ee5\u53ca\u6591\u5757\u7834\u88c2\u53d1\u751f\u53ca\u5176\u76f8\u5173\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u7406\u89e3\u7684\u91cd\u8981\u5de5\u5177\u3002\u6b64\u5916\uff0c\u52a8\u7269\u6a21\u578b\u88ab\u7528\u4e8e\u5141\u8bb8\u8bc4\u4f30\u53ef\u4ee5\u9884\u9632\u6216\u51cf\u7f13\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53d1\u4f5c\u7684\u65b0\u578b\u836f\u7269\u6cbb\u7597\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u52a8\u7269\u6a21\u578b\u57fa\u4e8e\u52a0\u901f\u6591\u5757\u5f62\u6210\uff0c\u539f\u56e0\u662f\uff1a(1) \u5bcc\u542b\u80c6\u56fa\u9187\/\u897f\u5f0f\u996e\u98df\uff0c(2) \u64cd\u7eb5\u53c2\u4e0e\u80c6\u56fa\u9187\u4ee3\u8c22\u7684\u57fa\u56e0\uff0c\u4ee5\u53ca (3) \u5f15\u5165\u989d\u5916\u7684\u98ce\u9669\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u56e0\u7d20\uff0c\u5982\u7cd6\u5c3f\u75c5\u3002<\/p>\n\n\n\n<p id=\"p0125\">\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u5c06\u8ba8\u8bba\u6709\u52a9\u4e8e\u7406\u89e3\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53ca\u5176\u4e34\u5e8a\u540e\u679c\u4ee5\u53ca\u663e\u8457\u6539\u5584\u6cbb\u7597\u7684\u52a8\u7269\u6a21\u578b\u3002<\/p>\n\n\n\n<p id=\"p0130\">\u5927\u91cf\u7814\u7a76\u8868\u660e\uff0c\u8840\u6d46\u4e2d\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d (LDL) \u7684\u9ad8\u6c34\u5e73\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6700\u7a81\u51fa\u7684\u5371\u9669\u56e0\u7d20\u4e4b\u4e00\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u503e\u5411\u4e8e\u5728\u52a8\u8109\u58c1\u7684\u5185\u76ae\u4e0b\u7a7a\u95f4\u79ef\u805a\u5e76\u9010\u6e10\u7ecf\u5386\u6c27\u5316\u4fee\u9970\u4ee5\u5f62\u6210\u6c27\u5316\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08oxLDL\uff09\u3002\u8fd9\u4f1a\u8bf1\u5bfc\u708e\u75c7\u53cd\u5e94\uff0c\u5176\u7279\u5f81\u5728\u4e8e\u5185\u76ae\u7ec6\u80de\u8fc7\u5ea6\u8868\u8fbe\u8d8b\u5316\u86cb\u767d\uff0c\u4f8b\u5982\u5355\u6838\u7ec6\u80de\u8d8b\u5316\u86cb\u767d-1 (MCP-1) \u548c\u7c98\u9644\u5206\u5b50\uff08\u8840\u7ba1\u7ec6\u80de\u7c98\u9644\u5206\u5b50-1 (VCAM-1)\u3001E-\u9009\u62e9\u7d20\u548c P-\u9009\u62e9\u7d20\uff09\u7ec6\u80de\uff08&nbsp;Fuster \u7b49\u4eba\uff0c2012 \u5e74\uff0cTabas \u7b49\u4eba\uff0c2015 \u5e74\uff09\u3002\u7c98\u9644\u5206\u5b50\u4fc3\u8fdb\u8840\u6db2\u643a\u5e26\u7684\u5355\u6838\u7ec6\u80de\u6d78\u6da6\u8fdb\u5165\u53d1\u708e\u7684\u52a8\u8109\u58c1\u3002\u5728\u5206\u5316\u4e3a\u5de8\u566c\u7ec6\u80de\u540e\uff0c\u8fd9\u4e9b\u7ec6\u80de\u541e\u566c oxLDL\uff0c\u8f6c\u5316\u4e3a\u6ce1\u6cab\u7ec6\u80de\uff0c\u5e76\u901a\u8fc7\u5206\u6ccc\u8840\u7ba1\u58c1\u708e\u75c7\u8fc7\u7a0b\u7684\u591a\u79cd\u4ecb\u8d28\u6765\u4fc3\u8fdb\u6591\u5757\u53d1\u80b2\uff08&nbsp;Sakakura \u7b49\u4eba\uff0c2013 \u5e74\uff09\u3002\u708e\u75c7\u53cd\u5e94\u4e5f\u4fc3\u8fdb\u5faa\u73af\u5355\u6838\u7ec6\u80de\u548ct\u7ec6\u80de\u7684\u8865\u5145\uff0c\u8fd9\u4e9b\u5355\u6838\u7ec6\u80de\u548ct\u7ec6\u80de\u523a\u6fc0\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de(SMCs)\u4ece\u88ab\u819c\u4ecb\u8d28\u8fc1\u79fb\u5230\u4e9a\u5185\u76ae\u7ec6\u80de\u7a7a\u95f4\uff0c\u5728\u90a3\u91cc\u5b83\u4eec\u8868\u73b0\u51fa\u5f02\u5e38\u9ad8\u7684\u589e\u6b96\u548c\u5206\u6ccc\u7ec6\u80de\u5916\u57fa\u8d28\u86cb\u767d\uff0c\u8fd9\u4e9b\u86cb\u767d\u4e5f\u4f1a\u4fc3\u8fdb\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u53d1\u751f\uff08Fuster et al., 2012\uff09\u3002\u665a\u671f\u4eba\u7c7b\u6591\u5757\u7684\u7279\u70b9\u662f:\u5927\u7684\u574f\u6b7b\u6838\u5fc3\uff0c\u8bb8\u591a\u8102\u8d28\u8d1f\u8f7d\u548c\u6fc0\u6d3b\u7684\u5de8\u566c\u7ec6\u80de\uff0c\u5c11\u91cf\u7684smc\uff0c\u6591\u5757\u5185\u65b0\u751f\u8840\u7ba1\u548c\u51fa\u8840\uff0c\u4ee5\u53ca\u5c06\u6591\u5757\u4e0e\u8840\u6d41\u5206\u79bb\u7684\u8584\u7ea4\u7ef4\u5e3d\u3002\u8fd9\u79cd\u9ad8\u5371\u6613\u635f\u6591\u5757\u7684\u7ea4\u7ef4\u5e3d\u7834\u88c2\u4f1a\u5bfc\u81f4\u8154\u5185\u8840\u6813\u5f62\u6210\u3001\u52a8\u8109\u95ed\u585e\u6216\u8fdc\u5904\u8840\u7ba1\u5e8a\u7684\u6813\u585e\uff0c\u4ece\u800c\u5bfc\u81f4\u5fc3\u808c\u6897\u6b7b\u3001\u4e2d\u98ce\u6216\u731d\u6b7b\uff08Berliner \u7b49\u4eba\uff0c1995 \u5e74\uff09\u3002\u5728\u4eba\u7c7b\u4e2d\uff0c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u901a\u5e38\u53ef\u4ee5\u5728\u4e3b\u52a8\u8109\u3001\u51a0\u72b6\u52a8\u8109\u4ee5\u53ca\u9888\u52a8\u8109\u548c\u8111\u52a8\u8109\u4e2d\u53d1\u73b0 (&nbsp;Lusis, 2000&nbsp;)\u3002<\/p>\n\n\n\n<p id=\"p0135\">1908 \u5e74\uff0cIgnatowski \u9996\u6b21\u7814\u7a76\u4e86\u5582\u98df\u5bcc\u542b\u80c6\u56fa\u9187\u996e\u98df\u7684\u5154\u5b50\u4e3b\u52a8\u8109\u58c1\u4e0a\u7684\u6591\u5757\u5f62\u6210\uff08Konstantinov \u548c Jankovic\uff0c2013 \u5e74\uff09\u3002\u4ece\u90a3\u65f6\u8d77\uff0c\u8bb8\u591a\u5176\u4ed6\u52a8\u7269\u7269\u79cd\uff0c\u5982\u5c0f\u9f20\u3001\u9e1f\u7c7b\u3001\u732a\u548c\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u90fd\u5f00\u59cb\u88ab\u7528\u4f5c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5b9e\u9a8c\u6a21\u578b\uff08Fuster \u7b49\u4eba\uff0c2012 \u5e74\uff0cKapourchali \u7b49\u4eba\uff0c2014 \u5e74\uff09\u3002<\/p>\n\n\n\n<p id=\"p0140\">\u7406\u60f3\u7684\u52a8\u7269\u6a21\u578b\u4e0e\u4eba\u4f53\u89e3\u5256\u5b66\u548c\u75c5\u7406\u751f\u7406\u5b66\u76f8\u4f3c\uff0c\u6709\u6f5c\u529b\u7528\u4e8e\u533b\u5b66\u548c\u836f\u7269\u7814\u7a76\uff0c\u4ee5\u83b7\u5f97\u53ef\u5916\u63a8\u5230\u4eba\u7c7b\u533b\u5b66\u7684\u7ed3\u679c\u3002\u6b64\u5916\uff0c\u91cd\u8981\u7684\u662f\uff0c\u7528\u4f5c\u6a21\u578b\u7684\u52a8\u7269\u6613\u4e8e\u83b7\u5f97\uff0c\u53ef\u4ee5\u4ee5\u5408\u7406\u7684\u6210\u672c\u8fdb\u884c\u7ef4\u62a4\uff0c\u6613\u4e8e\u5904\u7406\u5e76\u5177\u6709\u660e\u786e\u7684\u9057\u4f20\u7279\u5f81\u3002\u7528\u4e8e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7814\u7a76\u7684\u6709\u4ef7\u503c\u7684\u52a8\u7269\u6a21\u578b\u4e0d\u4ec5\u4e0e\u4eba\u7c7b\u6709\u7c7b\u4f3c\u7684\u75be\u75c5\u8fc7\u7a0b\u7684\u5173\u952e\u65b9\u9762\uff0c\u800c\u4e14\u6709\u76f8\u4f3c\u7684\u75c5\u7076\u7684\u5f62\u8c8c\u3002\u6b64\u5916\uff0c\u52a8\u7269\u6700\u597d\u5728\u6444\u5165\u7c7b\u4f3c\u4e8e\u4eba\u7c7b\u7684\u996e\u98df\u540e\u81ea\u53d1\u5730\u53d1\u751f\u75c5\u53d8\uff08Getz and Reardon, 2012\uff09\u3002\u867d\u7136\u4e00\u4e9b\u52a8\u7269\u5728\u98df\u7528\u5bcc\u542b\u80c6\u56fa\u9187\u7684\u996e\u98df\u540e\u4f1a\u51fa\u73b0\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\uff0c\u4f46\u4e0e\u4eba\u7c7b\u76f8\u6bd4\uff0c\u75c5\u53d8\u7684\u75c5\u7076\u5e76\u4e0d\u603b\u662f\u76f8\u4f3c\u7684\u3002\u6b64\u5916\uff0c\u91cd\u8981\u7684\u662f\u8981\u6ce8\u610f\uff0c\u5728\u5927\u591a\u6570\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6a21\u578b\u4e2d\uff0c\u52a8\u7269\u4e0d\u4f1a\u81ea\u53d1\u53d1\u5c55\u51fa\u4eba\u7c7b\u6240\u89c1\u7684\u5e76\u53d1\u75c7\uff0c\u4f8b\u5982\u6591\u5757\u7834\u88c2\u3001\u5fc3\u808c\u6897\u6b7b\u3001\u4e2d\u98ce\u548c\u731d\u6b7b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sect0020\">2&nbsp;.&nbsp;\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5c0f\u9f20\u6a21\u578b<\/h2>\n\n\n\n<p id=\"p0145\">\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5c0f\u9f20\u5df2\u6210\u4e3a\u7814\u7a76\u5b9e\u9a8c\u6027\u52a8\u8109\u7ca5\u6837\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5c0f\u9f20\u5df2\u7ecf\u6210\u4e3a\u7814\u7a76\u5b9e\u9a8c\u6027\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u4f18\u52bf\u7269\u79cd\uff0c\u56e0\u4e3a\u5b83\u80fd\u5feb\u901f\u7e41\u6b96\uff0c\u6613\u4e8e\u57fa\u56e0\u64cd\u4f5c\uff0c\u5e76\u4e14\u80fd\u591f\u5728\u5408\u7406\u7684\u65f6\u95f4\u6846\u67b6\u5185\u76d1\u6d4b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u53d1\u751f\uff08 Bond and Jackson, 2011&nbsp;,&nbsp;Getz and Reardon, 2012&nbsp;,&nbsp;Schwartz \u7b49\u4eba\uff0c2007 \u5e74\uff0c&nbsp;VanderLaan \u7b49\u4eba\uff0c2004 \u5e74\uff09\u3002\u7136\u800c\uff0c\u7531\u4e8e\u4e0e\u4eba\u7c7b\u76f8\u6bd4\uff0c\u5c0f\u9f20\u7684\u8102\u8d28\u7279\u5f81\u660e\u663e\u4e0d\u540c\uff0c\u56e0\u6b64\u5b83\u4eec\u5bf9\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u53d1\u751f\u5177\u6709\u76f8\u5bf9\u7684\u62b5\u6297\u529b\u3002\u56e0\u6b64\uff0c\u5bf9\u5b83\u4eec\u7684\u8102\u8d28\u4ee3\u8c22\u8fdb\u884c\u57fa\u56e0\u8c03\u63a7\u662f\u5fc5\u987b\u7684\uff08Getz \u548c Reardon\uff0c2012 \u5e74\uff0c&nbsp;Meir \u548c Leitersdorf\uff0c2004 \u5e74\uff09\uff09\u3002<\/p>\n\n\n\n<p id=\"p0145\">\u5728\u5c0f\u9f20\u4e2d\uff0c\u5927\u90e8\u5206\u80c6\u56fa\u9187\u901a\u8fc7\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d(HDL)\u6837\u9897\u7c92\u8fd0\u8f93\u3002\u56e0\u6b64\uff0c\u5c0f\u9f20\u53ea\u542b\u6709\u4f4e\u6d53\u5ea6\u7684\u81f4\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u548c\u6781\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d(VLDL)\u3002\u7f3a\u4e4f\u6e05\u9664\u8fd9\u4e9b\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u9897\u7c92\u7684\u53d7\u4f53\u7684\u5c0f\u9f20(LDLr-\/-\u5c0f\u9f20)\u7684\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u663e\u8457\u5347\u9ad8\u3002\u8f7d\u8102\u86cb\u767d E&nbsp;(ApoE) \u662f\u4e00\u79cd\u7cd6\u86cb\u767d\uff0c\u4e3b\u8981\u5728\u809d\u810f\u548c\u5927\u8111\u4e2d\u5408\u6210\uff0c\u4f5c\u4e3a\u53d7\u4f53\u7684\u914d\u4f53\uff0c\u53ef\u6e05\u9664\u4e73\u7cdc\u5fae\u7c92\u548c VLDL \u6b8b\u7559\u7269 (&nbsp;Meir \u548c Leitersdorf, 2004)\u3002\u7f3a\u4e4f\u8fd9\u79cd\u7cd6\u86cb\u767d\uff08ApoE<sup>-\/-<\/sup>) \u5bfc\u81f4\u8840\u6d46\u603b\u80c6\u56fa\u9187\u6c34\u5e73\u5347\u9ad8\uff0c\u4e3b\u8981\u662f VLDL \u548c\u4e73\u7cdc\u5fae\u7c92\u90e8\u5206\uff08Piedrahita \u7b49\u4eba\uff0c1992 \u5e74\uff09\uff0c\u9ad8\u8102\u80aa\u6216\u897f\u5f0f\u996e\u98df\u4f1a\u4f7f\u8840\u6d46\u603b\u80c6\u56fa\u9187\u6c34\u5e73\u589e\u52a0\u56db\u500d\uff08Plump \u7b49\u4eba\uff0c1992 \u5e74\uff09\u3002\u8fd9\u4e24\u79cd\u5c0f\u9f20\u6a21\u578b\u5df2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u7814\u7a76\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53d1\u751f\u548c\u8fdb\u5c55\u7684\u673a\u5236\u3002<\/p>\n\n\n\n<p id=\"p0145\">\u5c0f\u9f20\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\u53d1\u751f\u5728\u627f\u53d7\u4f4e\u526a\u5207\u5e94\u529b\u548c\/\u6216\u632f\u8361\u526a\u5207\u5e94\u529b\u7684\u8840\u7ba1\u7cfb\u7edf\u533a\u57df\uff08Bond and Jackson, 2011&nbsp;,&nbsp;VanderLaan et al., 2004&nbsp;\uff09\u3002\u5c0f\u9f20\u7684\u597d\u53d1\u90e8\u4f4d\u662f\u4e3b\u52a8\u8109\u6839\u90e8\u3001\u4e3b\u52a8\u8109\u5f13\u5c0f\u5f2f\u4ee5\u53ca\u5934\u81c2\u52a8\u8109\u3001\u5de6\u9888\u52a8\u8109\u548c\u9501\u9aa8\u4e0b\u52a8\u8109\u7684\u5206\u652f\u70b9\u3002\u7136\u800c\uff0c\u5728<a href=\"http:\/\/www.shuyudiet.com\/?s=%E9%AB%98%E8%83%86%E5%9B%BA%E9%86%87\">\u9ad8\u80c6\u56fa\u9187<\/a>\u996e\u98df\u4e2d\uff0c\u4e0eLDLr-\/-\u5c0f\u9f20\u76f8\u6bd4\uff0cApoE-\/-\u5c0f\u9f20\u5f62\u6210\u6591\u5757\u66f4\u5feb\uff0c\u5177\u6709\u66f4\u5148\u8fdb\u7684\u8868\u578b(Silvestre-Roigetal.\uff0c2014)\uff0c\u8fd9\u4f7f\u5f97ApoE-\/-\u6a21\u578b\u5e7f\u6cdb\u7528\u4e8e\u5b9e\u9a8c\u6027\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7814\u7a76\u3002<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib90\"><\/a><\/p>\n\n\n\n<p id=\"p0150\">\u8f7d\u8102\u86cb\u767d(Apo) E3-Leiden \u7a81\u53d8\u4e0e\u9ad8\u8102\u8840\u75c7\u7684\u9057\u4f20\u5f62\u5f0f\u6709\u5173\u3002\u56e0\u6b64\uff0cApoE3-Leiden\u8f6c\u57fa\u56e0\u5c0f\u9f20\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u6a21\u578b\uff0c\u4f46\u4e0e ApoE<sup>&nbsp;-\/-<\/sup>\u548c LDLr<sup>&nbsp;-\/-<\/sup>\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5b83\u4eec\u5728\u6b63\u5e38\u996e\u98df\u65f6\u663e\u793a\u51fa\u76f8\u5f53\u4f4e\u7684\u603b\u8840\u6d46\u80c6\u56fa\u9187\u548c\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u5bf9\u542b\u8102\u80aa\u3001\u7cd6\u548c\u80c6\u56fa\u9187\u7684\u996e\u98df\u53cd\u5e94\u5f3a\u70c8\uff0c\u4ece\u800c\u5bfc\u81f4\u8102\u86cb\u767d\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff08Zadelaar \u7b49\u4eba\uff0c2007 \u5e74\uff09\u3002\u65e0\u8bba\u75c5\u53d8\u53d1\u5c55\u5982\u4f55\uff0c\u4ece\u8102\u80aa\u6761\u7eb9\u5230\u8f7b\u5ea6\u3001\u4e2d\u5ea6\u548c\u91cd\u5ea6\u6591\u5757\uff0cApoE3-Leiden\u5c0f\u9f20\u7f3a\u4e4f\u6591\u5757\u7834\u88c2\u3001\u8840\u6813\u5f62\u6210\u548c\/\u6216\u51fa\u8840\u7b49\u5173\u952e\u4e8b\u4ef6\uff0c\u8fd9\u5728\u4eba\u7c7b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49 (&nbsp;Lutgens et al., 1999)\uff0c\u7f57\u65af\uff0c1995 \u5e74\uff09\u3002<\/p>\n\n\n\n<p id=\"p0155\">\u9ad8\u8840\u6d46\u8102\u86cb\u767d (a) [Lp(a)] \u662f LDL \u548c\u79f0\u4e3a\u8f7d\u8102\u86cb\u767d (a) [Apo(a)] \u7684\u5927\u7cd6\u86cb\u767d\u7684\u590d\u5408\u7269\uff0c\u662f\u4eba\u7c7b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53d1\u5c55\u7684\u72ec\u7acb\u5371\u9669\u56e0\u7d20\uff08Breslow\uff0c1993 \u5e74\uff0cGencer \u7b49\u4eba\uff0c2017 \u5e74\uff09\u3002\u9664\u4e86\u7075\u957f\u7c7b\u52a8\u7269\u5916\uff0c\u51e0\u4e4e\u6240\u6709\u7684\u7269\u79cd\u90fd\u7f3a\u4e4fApo(a)\uff0c\u8fd9\u59a8\u788d\u4e86\u4f7f\u7528\u65b9\u4fbf\u7684\u52a8\u7269\u6a21\u578b\u6765\u7814\u7a76\u5176\u5728\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u4f7f\u7528\u4e86\u8868\u8fbe\u4eba\u8f7d\u8102\u86cb\u767d(a)\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u3002\u5f53\u5582\u98df\u897f\u65b9\u578b\u996e\u98df\u65f6\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u663e\u793a\u51fa\u5de8\u566c\u7ec6\u80de\u6837\u7ec6\u80de\u7684\u5b58\u5728\uff0c\u5e76\u5728\u4e3b\u52a8\u8109\u57fa\u5e95\u90e8\u51fa\u73b0\u8102\u80aa\u6761\u7eb9\u75c5\u53d8(Lawnetal.\uff0c1992)\u3002\u5728\u4eba\u7c7b\u4e2d\uff0c\u8840\u6d46\u8f7d\u8102\u86cb\u767d(a)\u51e0\u4e4e\u5b8c\u5168\u4e0e\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u5171\u4ef7\u7ed3\u5408\uff0c\u800c\u5728\u5c0f\u9f20\u4e2d\uff0c\u8f7d\u8102\u86cb\u767d(a)\u4f5c\u4e3a\u975e\u8102\u86cb\u767d\u76f8\u5173\u7684\u8f7d\u8102\u86cb\u767d(a)\u5faa\u73af(Lawnetal.\uff0c1992)\u3002\u56e0\u6b64\uff0cApo(a)\u8f6c\u57fa\u56e0\u5c0f\u9f20\u53ef\u4ee5\u7528\u4e8e\u8bc6\u522bApo(a)\u5728\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53d1\u751f\u4e2d\u7684\u4f5c\u7528\uff0c\u800c\u4e0d\u4f9d\u8d56\u4e8e\u4eba\u7c7b\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u3002<\/p>\n\n\n\n<p id=\"p0160\">\u4e0b\u6587\u548c\u56fe1\u4e2d\u8be6\u7ec6\u63cf\u8ff0\u4e86\u6700\u5e38\u7528\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5c0f\u9f20\u6a21\u578b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0014299917303205-gr1.jpg\" alt=\"\"\/><figcaption class=\"wp-element-caption\">\u56fe1\u3002\u76ee\u524d\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5c0f\u9f20\u6a21\u578b\u7efc\u8ff0\u3002\u8fd9\u5f20\u56fe\u63cf\u8ff0\u4e86\u4e0d\u540c\u7684\u6a21\u578b\uff0c\u5305\u62ec\u6b63\u5e38\u996e\u98df(ND)\u548c\u897f\u5f0f\u996e\u98df(WD)\u4e0b\u7684\u8840\u6d46\u603b\u80c6\u56fa\u9187\u6c34\u5e73\u3001\u8102\u86cb\u767d\u8c31\u3001\u6591\u5757\u7279\u5f81\u3001\u4f18\u70b9\u548c\u5c40\u9650\u6027\u3002\u5582\u98df20\u5468\u7684\u5c0f\u9f20\u80f8\u4e3b\u52a8\u8109\u6591\u5757\u7684\u5206\u5e03\u548c\u590d\u6742\u6027\u3002\u5728\u8be5\u65f6\u95f4\u70b9\uff0c\u6700\u590d\u6742\u7684\u75c5\u53d8\u7684\u7ec4\u6210\u88ab\u663e\u793a\u51fa\u6765\uff08\u901a\u5e38\u53d1\u73b0\u5728\u4e3b\u52a8\u8109\u6839\u90e8\u6216\u5934\u81c2\u52a8\u8109\uff09\u3002<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sect0025\">2.1&nbsp;.&nbsp;\u8f7d\u8102\u86cb\u767d E \u7f3a\u4e4f (ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;) \u5c0f\u9f20<\/h3>\n\n\n\n<p id=\"p0165\">ApoE \u662f\u4e00\u79cd\u7cd6\u86cb\u767d\uff0c\u5206\u5b50\u5927\u5c0f\u7ea6\u4e3a 34&nbsp;kDa\u3002\u5b83\u4e3b\u8981\u5728\u809d\u810f\u548c\u5927\u8111\u4e2d\u5408\u6210\uff0c\u662f\u9664\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u5916\u6240\u6709\u8102\u86cb\u767d\u9897\u7c92\u7684\u7ed3\u6784\u6210\u5206\u3002\u5b83\u4f5c\u4e3a\u7ec6\u80de\u8868\u9762\u8102\u86cb\u767d\u53d7\u4f53\u7684\u914d\u4f53\uff0c\u5176\u529f\u80fd\u662f\u6e05\u9664\u4e73\u7cdc\u5fae\u7c92\u548c VLDL \u6b8b\u7559\u7269\u3002\u5b83\u4e5f\u7531\u5355\u6838\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u5408\u6210\uff08Curtiss \u548c Boisvert\uff0c2000\uff09\u3002\u5176\u4ed6\u529f\u80fd\u5305\u62ec\u80c6\u56fa\u9187\u7a33\u6001\u3001\u80c6\u56fa\u9187\u5728\u7ec4\u7ec7\u5185\u7684\u5c40\u90e8\u518d\u5206\u5e03\u3001\u514d\u75ab\u8c03\u8282\u4ee5\u53ca\u80c6\u56fa\u9187\u7684\u81b3\u98df\u5438\u6536\u548c\u80c6\u6c41\u6392\u6cc4\uff08Mahley\uff0c1988 \u5e74\uff0cSehayek \u7b49\u4eba\uff0c2000 \u5e74\uff09\u3002&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/lipoprotein-receptor\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/monocyte\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib17\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib60\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib88\"><\/a><\/p>\n\n\n\n<p id=\"p0170\">1992 \u5e74\uff0c\u4e24\u4e2a\u5b9e\u9a8c\u5ba4\u51e0\u4e4e\u540c\u65f6\u5f00\u53d1\u4e86\u7b2c\u4e00\u6279 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\uff08<sup>&nbsp;<\/sup>Piedrahita \u7b49\u4eba\uff0c1992 \u5e74\uff0cPlump \u7b49\u4eba\uff0c1992 \u5e74\uff09\u3002ApoE\u57fa\u56e0\u7684\u7f3a\u5931\u662f\u901a\u8fc7\u540c\u6e90\u91cd\u7ec4\u5728\u5c0f\u9f20\u80da\u80ce\u5e72\u7ec6\u80de\u4e2d\u5b8c\u6210\u7684\u3002ApoE<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/homologous-recombination\"><\/a><sup>&nbsp;-\/-<\/sup>\u5c0f\u9f20\u5f88\u5065\u5eb7\uff0c\u4f53\u91cd\u4e0e\u91ce\u751f\u578b\u5c0f\u9f20\u76f8\u4f3c\uff0c\u5e76\u4e14\u4ee5\u9884\u671f\u7684\u9891\u7387\u51fa\u751f\uff08Jawien \u7b49\u4eba\uff0c2004 \u5e74\uff0cPlump \u7b49\u4eba\uff0c1992 \u5e74\uff09\u3002\u7136\u800c\uff0c\u5b83\u4eec\u7684\u8102\u86cb\u767d\u8c31\u63ed\u793a\u4e86\u4e0e\u540c\u6837\u80cc\u666f\u7684\u91ce\u751f\u578b\u5c0f\u9f20\u7684\u663e\u7740\u5dee\u5f02\u3002ApoE-\/-\u5c0f\u9f20\u6e05\u9664\u8840\u6d46\u8102\u86cb\u767d\u7684\u80fd\u529b\u4e25\u91cd\u53d7\u635f\uff0c\u5bfc\u81f4\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u4e3a400-600mg\/dl\uff0c\u800c\u91ce\u751f\u578b\u5c0f\u9f20\u7684\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u4e3a75-110mg\/dl(&nbsp;Nakashima et al., 1994&nbsp;,&nbsp;Plump and\u5e03\u96f7\u65af\u6d1b\uff0c1995 \u5e74\uff09\u3002\u8fd9\u79cd\u5267\u70c8\u7684\u53d8\u5316\u662f\u7531\u4e8eVLDL\u7c92\u5b50\u7684\u5927\u5c0f\u7684\u589e\u52a0\u3002\u5373\u4f7f\u6b63\u5e38\u996e\u98df\u4e5f\u4f1a\u51fa\u73b0\u663e\u8457\u7684\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff0c\u8fd9\u8868\u660e\u5728\u6ca1\u6709\u73af\u5883\u523a\u6fc0\u7684\u60c5\u51b5\u4e0b\uff0c\u8f7d\u8102\u86cb\u767de\u7684\u7f3a\u4e4f\u8db3\u4ee5\u5f15\u8d77\u8102\u86cb\u767d\u4ee3\u8c22\u7684\u5de8\u5927\u53d8\u5316\u3002\u6b64\u5916\uff0c\u8f7d\u8102\u86cb\u767de\u7684\u7f3a\u4e4f\u63d0\u9ad8\u4e86\u5bf9\u81b3\u98df\u8102\u80aa\u548c\u80c6\u56fa\u9187\u7684\u654f\u611f\u6027\u3002\u7ecf\u8fc7\u51e0\u5468\u7684\u897f\u5f0f\u996e\u98df\uff08\u5305\u62ec21%\u65e0\u6c34\u5976\u6cb9\u548c0.15%\u80c6\u56fa\u9187\uff0c\u4e0e\u897f\u65b9\u56fd\u5bb6\u7684\u65e5\u5e38\u996e\u98df\u76f8\u4f3c\uff09\uff0c\u91ce\u751f\u578b\u5c0f\u9f20\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u589e\u52a0\u4e862\u500d\uff0c\u800capoe\u7f3a\u4e4f\u5c0f\u9f20\u8840\u6d46\u603b\u80c6\u56fa\u9187\u6c34\u5e73\u589e\u52a0\u4e864\u500dPlump \u7b49\uff0c1992\uff09\u3002\u4e24\u79cd\u996e\u98df\uff08<a href=\"http:\/\/www.shuyudiet.com\/diet\/264.html\">\u897f\u65b9\u996e\u98df<\/a>\u548c\u6b63\u5e38\u996e\u98df\uff09\u7684ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u5728 2-3 \u4e2a\u6708\u5927\u65f6\u90fd\u51fa\u73b0\u5e7f\u6cdb\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff08Reddick \u7b49\uff0c1994\uff09\u3002\u53e6\u4e00\u65b9\u9762,\u6742\u5408\u7684ApoE-deficient\u8001\u9f20\u5373\u4f7f\u5728\u897f\u5f0f\u996e\u98df\u7684\u9972\u5582\u7684\u60c5\u51b5\u4e0b\uff0c\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u5e76\u6ca1\u6709\u4efb\u4f55\u589e\u52a0\uff0c\u56e0\u6b64\uff0c\u6211\u4eec\u8ba4\u5b9a\uff0c\u964d\u4f4e50%\u7684\u8f7d\u8102\u86cb\u767de\u662f\u4e0d\u8db3\u4ee5\u63d0\u5347\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5c0f\u9f20\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u4e0d\u53d7\u52a8\u7269\u5e74\u9f84\u6216\u6027\u522b\u7684\u5f71\u54cd\uff08Nakashima \u7b49\u4eba\uff0c1994 \u5e74\uff09\u3002<\/p>\n\n\n\n<p id=\"p0175\">ApoE<sup>&nbsp;-\/-<\/sup>\u5c0f\u9f20\u4e2d\u5b58\u5728\u6574\u4e2a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\u8c31\uff08&nbsp;Jawien \u7b49\uff0c2004&nbsp;\uff09\u3002\u4ece 6 \u5468\u9f84\u5f00\u59cb\u6ce8\u610f\u5230\u5355\u6838\u7ec6\u80de\u4e0e\u5185\u76ae\u7ec6\u80de\u7684\u9644\u7740\uff0c\u5e76\u4e14\u5728 8 \u5468\u9f84\u540e\u53ef\u68c0\u6d4b\u5230\u6ce1\u6cab\u7ec6\u80de\u75c5\u53d8\u7684\u53d1\u5c55\u300215-20 \u5468\u540e\uff0c\u51fa\u73b0\u4e2d\u95f4\u75c5\u53d8\uff0c\u4e3b\u8981\u5305\u542b SMC \u4ee5\u53ca\u7531 SMC\u3001\u7ec6\u80de\u5916\u57fa\u8d28\u548c\u8986\u76d6\u6709\u7ea4\u7ef4\u5e3d\u7684\u574f\u6b7b\u6838\u5fc3\u7ec4\u6210\u7684\u7ea4\u7ef4\u6591\u5757\uff08Nakashima \u7b49\uff0c1994\uff09\u3002\u5728\u66f4\u665a\u671f\u7684\u75c5\u53d8\u4e2d\uff0c\u7ea4\u7ef4\u7624-\u8102\u80aa\u7ed3\u8282\u662f\u9499\u5316\u7684\u75c5\u7076\uff0c\u6591\u5757\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u53d8\u5f97\u9499\u5316\u7a0b\u5ea6\u66f4\u9ad8\uff08Rattazzi \u7b49\uff0c2005\uff09\u3002\u5f53\u5582\u98df\u897f\u5f0f\u996e\u98df\u65f6\uff0c\u75c5\u53d8\u5f62\u6210\u7684\u65f6\u95f4\u8fc7\u7a0b\u4f1a\u5927\u5927\u52a0\u5feb\uff08Jawien \u7b49\u4eba\uff0c2004 \u5e74\uff09\u3002\u4e0e\u5582\u98df\u4f4e\u8102\u996e\u98df\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5728\u540c\u4e00\u65f6\u671f\u5185\uff0c\u75c5\u53d8\u5927 3-4 \u500d\u3002\u8fd9\u79cd\u53cd\u5e94\u610f\u5473\u7740\u4e00\u79cd\u996e\u98df\u4f9d\u8d56\u6027\u673a\u5236\uff0c\u5373\u8102\u80aa\u3001\u80c6\u56fa\u9187\u7684\u589e\u52a0\u5bfc\u81f4\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u7684\u63d0\u5347\uff0c\u8fdb\u800c\u5bfc\u81f4\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u53d1\u5c55\u52a0\u5feb\uff0c\u8fd9\u5c31\u7c7b\u4f3c\u4e8e\u5728\u4eba\u7c7b\u4e2d\u89c2\u5bdf\u5230\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6027\u5fc3\u810f\u75c5\u7684\u996e\u98df\u4f9d\u8d56\u6027\uff08 Plump \u7b49\uff0c1992\uff09\u3002<\/p>\n\n\n\n<p id=\"p0180\">ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u503e\u5411\u4e8e\u5728\u8840\u7ba1\u5206\u652f\u70b9\u5f62\u6210\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\uff0c\u597d\u53d1\u4e8e\u4e3b\u52a8\u8109\u6839\u90e8\u3001\u4e3b\u52a8\u8109\u5f13\u5c0f\u5f2f\u3001\u4e3b\u52a8\u8109\u4e3b\u8981\u5206\u652f\u4ee5\u53ca\u80ba\u52a8\u8109\u548c\u9888\u52a8\u8109\uff08Nakashima \u7b49\u4eba\uff0c 1994 \u5e74\uff09\u3002ApoE<sup>-\/-<\/sup>\u5c0f\u9f20\u6591\u5757\u5f62\u6210\u7684\u8fde\u7eed\u8fdb\u7a0b\uff0c\u4e0e\u5df2\u5728\u5927\u52a8\u7269\u4e2d\u5efa\u7acb\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u52a8\u7269\u6a21\u578b\u4ee5\u53ca\u4eba\u7c7b\u76f8\u5f53\u76f8\u4f3c\uff08Nakashima \u7b49\u4eba\uff0c1994 \u5e74\uff09\uff09\u3002\u5c3d\u7ba1\u8bb8\u591a\u7814\u7a76\u5c0f\u7ec4\u90fd\u4f7f\u7528\u8fd9\u79cd\u5c0f\u9f20\u6a21\u578b\uff0c\u4f46\u5b83\u6709\u4e00\u4e9b\u5c40\u9650\u6027\u3002\u4f8b\u5982\uff0cApoE \u662f\u4e00\u79cd\u591a\u529f\u80fd\u86cb\u767d\uff0c\u5b83\u5bf9\u708e\u75c7\u3001\u6c27\u5316\u3001\u5de8\u566c\u7ec6\u80de\u7684\u80c6\u56fa\u9187\u9006\u5411\u8f6c\u8fd0\u4ee5\u53ca\u5e73\u6ed1\u808c\u589e\u6b96\u548c\u8fc1\u79fb\u6709\u5f71\u54cd\u3002\u8fd9\u4e9b\u529f\u80fd\u53ef\u80fd\u4f1a\u5f71\u54cd ApoE<sup>&nbsp;-\/-<\/sup>\u5c0f\u9f20\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u53d1\u80b2\uff0c\u4e0e\u8840\u6d46\u8102\u8d28\u6c34\u5e73\u65e0\u5173\uff08Getz \u548c Reardon\uff0c2009 \u5e74\uff09\u3002\u5728ApoE<sup>-\/-<\/sup>\u5c0f\u9f20\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u8102\u86cb\u767d\u4e0d\u662f\u4eba\u7c7b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7279\u6709\u7684LDL\uff0c\u800c\u662fVLDL\uff08Plump \u7b49\uff0c1992\uff09\u3002\u7136\u800c\uff0c\u201c\u7ecf\u5178\u201d\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5c0f\u9f20\u6a21\u578b\u7684\u4e3b\u8981\u5c40\u9650\u6027\u662f\u6591\u5757\u7834\u88c2\u548c\u8840\u6813\u5f62\u6210\u7684\u7f55\u89c1\u6027(Plump\u548cLum, 2009;Smith\u548cBreslow, 1997)\uff0c\u800c\u8fd9\u4e9b\u4e8b\u4ef6\u5728\u4eba\u7c7b\u4e2d\u76f8\u5f53\u5e38\u89c1\uff0c\u53ef\u5bfc\u81f4MI\u548c\u4e2d\u98ce(Jawien\u7b49\u4eba\uff0c2004)\u3002\u6709\u4eba\u63d0\u51fa\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u5c0f\u9f20\u8840\u7ba1\u7684\u76f4\u5f84\u5f88\u5c0f\u3002\u968f\u7740\u8840\u7ba1\u76f4\u5f84\u51cf\u5c0f\uff0c\u8868\u9762\u5f20\u529b\u5448\u6307\u6570\u589e\u52a0\uff0c\u4ece\u800c\u963b\u6b62\u6591\u5757\u7834\u88c2\u7684\u53ef\u80fd\u6027\uff08Jawien \u7b49\u4eba\uff0c2004 \u5e74\uff09\u3002\u7136\u800c\uff0c\u8fd8\u5fc5\u987b\u8003\u8651\u5176\u4ed6\u89e3\u91ca\uff0c\u5982\u4e0b\u6587\u201c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7834\u88c2\u7684\u5c0f\u9f20\u6a21\u578b\u201d\u90e8\u5206\u6240\u8ff0\u3002<\/p>\n\n\n\n<p id=\"p0185\">\u4e00\u79cd\u8bf1\u5bfc\u52a0\u901f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u548c\u6591\u5757\u7834\u88c2\u7684\u65b9\u6cd5\u662f\u5bf9 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u8fdb\u884c\u624b\u672f\u5e72\u9884\uff0c\u5bf9\u8840\u7ba1\u8fdb\u884c\u6346\u624e\u4ee5\u4fc3\u8fdb\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6a21\u578b\u8fdb\u4e00\u6b65\u5f62\u6210\u677f\u5757\u7834\u88c2\u3001\u8840\u6813\u7b49\u3002Sasaki \u7b49\u4eba\u5728\u4ed6\u4eec\u7684\u7814\u7a76\u4e2d\u58f0\u79f0\uff0c\u5728\u5de6\u9888\u52a8\u8109\u5468\u56f4\u8fdb\u884c\u6346\u624e\u624b\u672f\u4f1a\u5bfc\u81f4\u6591\u5757\u7834\u88c2\u7684\u52a8\u7269\u6a21\u578b\u3002\u901a\u8fc7\u4f7f\u7528\u7ed3\u624e\u6280\u672f\u8bf1\u5bfc\u65b0\u751f\u5185\u819c\u589e\u751f\uff0c\u4ed6\u4eec\u89c2\u5bdf\u5230\u5bcc\u542b\u8102\u8d28\u548c\u80f6\u539f\u86cb\u767d\u7684\u75c5\u53d8\u4f34\u6709\u6591\u5757\u5185\u51fa\u8840\u548c\u6591\u5757\u7834\u88c2\u3002\u6b64\u5916\uff0c\u68c0\u6d4b\u5230\u80f6\u539f\u86cb\u767d\u542b\u91cf\u51cf\u5c11\u548c\u7ea4\u7ef4\u86cb\u767d\u539f\u9633\u6027\u8840\u6813\u5f62\u6210\uff0c\u7c7b\u4f3c\u4e8e\u4eba\u7c7b\u6591\u5757\u7834\u88c2\uff08Sasaki \u7b49\u4eba\uff0c2006 \u5e74\uff09\u3002\u9664\u4e86\u8fd9\u4e00\u89c2\u5bdf\u4e4b\u5916\uff0c\u8840\u7ba1\u5468\u56f4\u9888\u52a8\u8109\u73af\u7684\u7ed3\u624e\u4e5f\u518d\u73b0\u4e86\u5feb\u901f\u548c\u90e8\u4f4d\u63a7\u5236\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u8bf1\u5bfc\u3002von der Thusen \u7b49\u4eba\uff0c2001 \u5e74\uff09\uff0c\u540c\u65f6\u4fdd\u6301\u5185\u76ae\u7684\u7ed3\u6784\u5b8c\u6574\u6027\u3002\u5f62\u6210\u7684\u6591\u5757\u4e3b\u8981\u4f4d\u4e8e\u9760\u8fd1\u7ed3\u624e\u7684\u533a\u57df\u3002\u8be5\u6a21\u578b\u76f8\u5bf9\u4e8e\u673a\u68b0\u8bf1\u5bfc\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u4f20\u7edf\u52a8\u7269\u6a21\u578b\u7684\u4f18\u52bf\u5728\u4e8e\uff0c\u4e0e\u4eba\u7c7b\u6591\u5757\u5f62\u6001\u548c\u5185\u76ae\u8868\u8fbe\u6a21\u5f0f\u66f4\u76f8\u4f3c\uff08von der Thusen \u7b49\u4eba\uff0c2001\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sect0030\">2.2&nbsp;.&nbsp;LDL\u53d7\u4f53\u7f3a\u9677\u578b\uff08LDLr&nbsp;<sup>-\/-<\/sup>\uff09\u5c0f\u9f20<\/h3>\n\n\n\n<p id=\"p0190\">LDL\u53d7\u4f53\u662f\u4e00\u79cd\u5206\u5b50\u91cf\u4e3a160&nbsp;kDa\u7684<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/endocytosis\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/familial-hypercholesterolemia\"><\/a>\u819c\u53d7\u4f53\uff0c\u5b83\u4ecb\u5bfc\u5bcc\u542b\u80c6\u56fa\u9187\u7684LDL\u7684\u5185\u541e\u4f5c\u7528\uff0c\u4ece\u800c\u7ef4\u6301\u8840\u6d46\u4e2d\u7684LDL\u6c34\u5e73\u3002\u5b83\u8fd8\u6709\u52a9\u4e8e\u7ec6\u80de\u6444\u53d6\u542b\u6709\u8f7d\u8102\u86cb\u767dB\u548cE\u7684\u8102\u86cb\u767d\u3002\u5b83\u8fd8\u80fd\u4fc3\u8fdb\u7ec6\u80de\u5bf9\u542b\u8f7d\u8102\u86cb\u767dB-\u548ce-\u7684\u8102\u86cb\u767d\u7684\u6444\u53d6\u3002\u5728\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u4e2d\u6240\u63cf\u8ff0\u7684\u8868\u578b\u4e8b\u4ef6\u4e2d\uff0c\u540c\u65f6\u7f16\u7801\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u8ba1\u6570\u7684\u57fa\u56e0\u53d1\u751f\u7a81\u53d8(&nbsp;Defesche, 2004&nbsp;,&nbsp;Marais, 2004&nbsp;)\u30021993 \u5e74\u521b\u5efa\u4e86 LDL \u53d7\u4f53\u9776\u5411\u5931\u6d3b\u7684\u5c0f\u9f20\uff08Ishibashi \u7b49\u4eba\uff0c1993\uff0cIshibashi \u7b49\u4eba\uff0c1994a\uff09\u3002\u4e0e\u91ce\u751f\u578b\u76f8\u6bd4\uff0cLDLr<sup>-\/-<\/sup>\u5c0f\u9f20\u5728\u5582\u98df\u6b63\u5e38\u996e\u98df\u5582\u517b\u65f6\uff0c\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u7565\u6709\u5347\u9ad8\uff0c\u6ca1\u6709\u6216\u4ec5\u51fa\u73b0\u8f7b\u5ea6\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff08Ishibashi \u7b49\uff0c1994a\uff09\u3002\u5c31\u8102\u86cb\u767d\u9897\u7c92\u800c\u8a00\uff0cIDL \u548c LDL\u9897\u7c92\u7684\u5927\u5c0f\u7684\u589e\u52a0\u66f4\u9ad8\uff0c\u800c HDL \u548c\u7518\u6cb9\u4e09\u916f\u4e0d\u53d7\u5f71\u54cd\uff08Ishibashi \u7b49\u4eba\uff0c1993\uff0cIshibashi \u7b49\u4eba\uff0c1994a\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e0eApoE-\/-\u5c0f\u9f20\u4e0d\u540c\uff0c\u5728ApoE\u4e2d\uff0c\u80c6\u56fa\u9187\u4e3b\u8981\u79ef\u7d2f\u5728\u5927\u8102\u86cb\u767d\u9897\u7c92\u4e2d\uff0c\u5982\u4e73\u7cdc\u5fae\u7c92\u6b8b\u4f59\u3001VLDL\u548cIDL\u9897\u7c92\uff08\u89c1\u4e0a\uff09\uff08Plump \u7b49\u4eba\uff0c1992\uff1bZhang \u7b49\u4eba, 1992\uff09\u3002\u5bf9\u9ad8\u8102\u80aa\/\u9ad8\u80c6\u56fa\u9187\u897f\u5f0f\u996e\u98df\u7684\u53cd\u5e94\u663e\u793a\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u7684\u8102\u86cb\u767d\u8c31\u53d1\u751f\u4e86\u663e\u8457\u53d8\u5316\uff0c\u4e14\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\u53d1\u5c55\u7684\u53ef\u80fd\u6027\u5f88\u9ad8\u3002<\/p>\n\n\n\n<p id=\"p0195\">\u5728 LDLr<sup>&nbsp;-\/-<\/sup>\u5c0f\u9f20\u4e2d\u5f62\u6210\u7684\u6591\u5757\u901a\u5e38\u4e0e\u5728 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u4e2d\u770b\u5230\u7684\u6591\u5757\u76f8\u540c\uff08Knowles \u548c Maeda\uff0c2000 \u5e74\uff09\u3002\u897f\u5f0f\u996e\u98df\u4f1a\u5bfc\u81f4\u66f4\u5927\u3001\u66f4\u4e25\u91cd\u7684\u75c5\u53d8\uff0c\u6709\u5bcc\u542b\u80f6\u539f\u7684\u7ea4\u7ef4\u5e3d\uff0c\u574f\u6b7b\u7684\u6838\u5fc3\u542b\u6709\u80c6\u56fa\u9187\u7ed3\u6676\uff0c\u7ec6\u80de\u5728\u7ba1\u8154\u9644\u8fd1\u5bcc\u96c6\uff08Hartvigsen \u7b49\uff0c2007\uff09\u3002\u6591\u5757\u53d1\u5c55\u4ee5\u65f6\u95f4\u4f9d\u8d56\u6027\u65b9\u5f0f\u53d1\u751f\uff0c\u6700\u521d\u5728\u8fd1\u7aef\u4e3b\u52a8\u8109\uff0c\u7136\u540e\u5411\u8fdc\u7aef\u4e3b\u52a8\u8109\u6269\u6563\u3002\u4e0e\u4eba\u7c7b\u76f8\u4f3c\uff0c\u8840\u6d41\u53d7\u5e72\u6270\u7684\u90e8\u4f4d\u66f4\u5bb9\u6613\u51fa\u73b0\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\uff08Knowles \u548c Maeda\uff0c2000 \u5e74\uff09\u3002\u901a\u8fc7\u4f7f LDLr&nbsp;<sup>-\/-<\/sup>\u548c ApoE&nbsp;<sup>-\/-<\/sup>\u6210\u4e3a ApoB-100 \u7b49\u4f4d\u57fa\u56e0\u7eaf\u5408\u7684\u5c0f\u9f20\uff0c\u4e8c\u8005\u53ef\u4ee5\u5728\u6b63\u5e38\u996e\u98df\u4e2d\u83b7\u5f97\u7ea6 300 mg\/dl \u7684\u603b\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u3002LDLr&nbsp;<sup>-\/-<\/sup>&nbsp;ApoB 100\/100 \u5c0f\u9f20\u6bd4 ApoE&nbsp;<sup>-\/-&nbsp;<\/sup>ApoB&nbsp;<sup>100\/100<\/sup>\u5c0f\u9f20\u51fa\u73b0\u66f4\u591a\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\uff0c\u5373\u4f7f\u5728\u6b63\u5e38\u996e\u98df\u7684\u60c5\u51b5\u4e0b\u4e5f\u662f\u5982\u6b64\uff08V\u00e9niant \u7b49\u4eba\uff0c2000 \u5e74\uff0cVeniant \u7b49\u4eba\uff0c2001 \u5e74\uff09\u3002<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib102\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib101\"><\/a><\/p>\n\n\n\n<p id=\"p0200\">\u4e0e ApoE<sup>&nbsp;-\/-<\/sup>\u5c0f\u9f20\u76f8\u6bd4\uff0cLDLr&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u6a21\u578b\u5177\u6709\u4e00\u4e9b\u4f18\u52bf\u3002\u9996\u5148\uff0c\u8840\u6d46\u80c6\u56fa\u9187\u4e3b\u8981\u7531 LDL \u9897\u7c92\u643a\u5e26\uff0c\u4ece\u800c\u4ea7\u751f\u66f4\u50cf\u4eba\u7c7b\u7684\u8102\u8d28\u5206\u5e03\u3002\u5176\u6b21\uff0c\u4e0e ApoE \u7f3a\u4e4f\u76f8\u6bd4\uff0c\u7f3a\u4e4f LDL \u53d7\u4f53\u5bf9\u708e\u75c7\u6ca1\u6709\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u8be5\u5c0f\u9f20\u6a21\u578b\u4e2d\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7684\u5f62\u6210\u662f\u57fa\u4e8e\u8840\u6d46\u8102\u8d28\u6c34\u5e73\u5347\u9ad8\uff0c\u800c\u4e0d\u662f\u7531\u4e0e LDL \u53d7\u4f53\u76f8\u5173\u7684\u5176\u4ed6\u529f\u80fd\u5f15\u8d77\u7684 (&nbsp;Getz and Reardon, 2012&nbsp;)\u3002\u7b2c\u4e09\uff0cLDLr&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u6a21\u578b\u5177\u6709\u5728\u4eba\u7c7b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u4e2d\u89c2\u5bdf\u5230\u7684\u7279\u5f81\uff0c\u8fd9\u662f\u7531\u529f\u80fd\u6027 LDL \u53d7\u4f53\u7f3a\u5931\u5f15\u8d77\u7684 (&nbsp;Hobbs et al., 1990&nbsp;,&nbsp;Lee et al., 2017<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib27\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib32\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib54\"><\/a>\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sect0035\">2.3&nbsp;.&nbsp;ApoE\/LDL\u53d7\u4f53\u53cc\u6572\u9664\u5c0f\u9f20<\/h3>\n\n\n\n<p id=\"p0205\">\u5728 ApoE<sup>&nbsp;-\/-<\/sup>\u548c LDLr&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u4e4b\u540e\u4e0d\u4e45\u5f15\u5165\uff0cApoE\/LDL \u53d7\u4f53\u53cc\u6572\u9664\u5c0f\u9f20\u4ee3\u8868\u4e86\u4e00\u79cd\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u6bd4\u4ee5\u524d\u7684\u6a21\u578b\u53d1\u5c55\u4e3a\u66f4\u4e25\u91cd\u7684\u9ad8\u8102\u8840\u75c7\u548c\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff08Bonthu \u7b49\u4eba\uff0c1997\uff09\u3002\u8fd9\u662f\u4e00\u79cd\u5177\u6709\u81ea\u53d1\u6027\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u53d1\u5c55\u7684\u52a8\u7269\u6a21\u578b\uff0c\u636e\u62a5\u9053\uff0c\u5373\u4f7f\u5728\u6b63\u5e38\u996e\u98df\u7684\u60c5\u51b5\u4e0b\uff0cApoE\/LDL \u53d7\u4f53\u53cc\u6572\u9664\u5c0f\u9f20\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8fdb\u5c55\u901a\u5e38\u6bd4\u5355\u72ec\u7f3a\u4e4f ApoE \u7684\u5c0f\u9f20\u66f4\u660e\u663e\uff08Witting \u7b49\u4eba., 1999 \u5e74\uff09\u3002\u4e0e ApoE<sup>&nbsp;-\/-<\/sup>\u5c0f\u9f20\u76f8\u6bd4\uff0c\u53cc\u6572\u9664\u7684\u8102\u86cb\u767d\u8c31\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff0c\u9664\u4e86 B48 \u548cB100 \u8f7d\u8102\u86cb\u767d\u7684\u663e\u7740\u5347\u9ad8\uff08Ishibashi \u7b49\u4eba\uff0c1994b\uff09\uff0c\u5b83\u4eec\u90fd\u5177\u6709\u9ad8\u6c34\u5e73\u7684 VLDL \u548c LDL (&nbsp;Caligiuri et al., 1999)\u3002\u8fd9\u79cd\u5c0f\u9f20\u6a21\u578b\u88ab\u8ba4\u4e3a\u9002\u5408\u7814\u7a76\u53ef\u80fd\u7684\u6cbb\u7597\u65b9\u6cd5\u7684\u6297\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4f5c\u7528\uff0c\u800c\u4e0d\u9700\u8981\u81f4\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u996e\u98df\uff08Jawien \u7b49\u4eba\uff0c2004 \u5e74\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sect0040\">2.4&nbsp;.&nbsp;ApoE3-Leiden \u5c0f\u9f20<\/h3>\n\n\n\n<p id=\"p0210\">\u5c3d\u7ba1 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u548c LDLr&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6700\u5e38\u7528\u7684\u4e24\u79cd\u5c0f\u9f20\u6a21\u578b\uff0c\u4f46 ApoE3-Leiden \u5c0f\u9f20\u4e5f\u88ab\u7528\u4e8e\u8bb8\u591a\u7814\u7a76\u3002\u8f7d\u8102\u86cb\u767d (Apo)E3-Leiden \u4e0e\u9ad8\u8102\u8840\u75c7\u7684\u9057\u4f20\u5f62\u5f0f\u6709\u5173\uff0c\u5c24\u5176\u5728\u8377\u5170\u5bb6\u65cf\u4e2d\u8868\u8fbe\u3002\u5df2\u4f7f\u7528\u4ece APOE3-Leiden \u5148\u8bc1\u8005\u4e2d\u5206\u79bb\u7684 27 \u5343\u78b1\u57faDNA \u6784\u5efa\u4f53\uff08\u5305\u542b ApoE \u57fa\u56e0\u3001ApoC1 \u57fa\u56e0\u548c\u6240\u6709\u8c03\u63a7\u5143\u4ef6\uff09\u751f\u6210\u8f6c\u57fa\u56e0\u5c0f\u9f20\uff0c\u4ee5\u7814\u7a76 ApoE3-Leiden \u7a81\u53d8\u5728\u4f53\u5185\u7684\u5f71\u54cd\uff08(Lutgens et al., 1999; van den Maagdenberg et al., 1993)\uff09\u3002<\/p>\n\n\n\n<p id=\"p0215\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u5c0f\u9f20\u5bf9\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u654f\u611f\u6027\u4f4e\u4e8e ApoE \u7f3a\u9677\u5c0f\u9f20\uff0c\u4f46\u5728\u5582\u98df\u897f\u5f0f\u996e\u98df\u65f6\uff0c\u5b83\u4eec\u7684\u603b\u8840\u6d46\u80c6\u56fa\u9187\u548c\u7518\u6cb9\u4e09\u916f\u6c34\u5e73\u4e5f\u663e\u7740\u5347\u9ad8\u3002\u8fd9\u4e3b\u8981\u5f52\u56e0\u4e8e VLDL\/LDL \u9897\u7c92\u7684\u589e\u52a0\uff0c\u8fd9\u8868\u660e ApoE3-Leiden \u5c0f\u9f20\u5177\u6709\u7c7b\u4f3c\u4eba\u7c7b\u7684\u8102\u86cb\u767d\u8c31\uff08van Vlijmen \u7b49\uff0c1994\uff09\u3002\u53e6\u4e00\u4e2a\u4f18\u70b9\u662f ApoE3-Leiden \u5c0f\u9f20\u5177\u6709\u5408\u6210\u529f\u80fd\u6027 ApoE \u7684\u80fd\u529b\u3002\u8fd9\u63d0\u4f9b\u4e86\u5728\u4e0d\u5e72\u6270\u708e\u75c7\u8fc7\u7a0b\u7684\u60c5\u51b5\u4e0b\u7814\u7a76\u5347\u9ad8\u7684\u8840\u6d46\u8102\u8d28\u6c34\u5e73\u7684\u5f71\u54cd\u7684\u53ef\u80fd\u6027\uff0c\u8fd9\u662f\u201c\u7ecf\u5178\u201dApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u6a21\u578b\u7684\u4e00\u4e2a\u91cd\u8981\u9650\u5236\uff08Gijbels \u7b49\uff0c1999\uff09\u3002<\/p>\n\n\n\n<p id=\"p0220\">\u5f53\u5582\u98df\u897f\u65b9\u996e\u98df\u65f6\uff0cApoE3-Leiden \u5c0f\u9f20\u7684\u4e3b\u52a8\u8109\u548c\u5927\u8840\u7ba1\u4f1a\u51fa\u73b0\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\u3002\u75c5\u53d8\u4e5f\u53ef\u89c1\u4e8e\u51a0\u72b6\u52a8\u8109\u8fd1\u7aef\u3001\u4e3b\u52a8\u8109\u6839\u90e8\u3001\u4e3b\u52a8\u8109\u5f13\u53ca\u5176\u4e3b\u8981\u5206\u652f\u70b9\u3001\u80f8\u4e3b\u52a8\u8109\u3001\u8179\u4e3b\u52a8\u8109\u3001\u80be\u52a8\u8109\u5206\u652f\u70b9\u3001\u8179\u4e3b\u52a8\u8109\u5206\u53c9\u5904\u548c\u9ac2\u52a8\u8109\u5206\u53c9\u5904\u3002\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u79cd\u57fa\u56e0\u578b\u5c0f\u9f20\u5728\u6b63\u5e38\u996e\u98df\u4e2d\u4f1a\u51fa\u73b0\u65e9\u671f\u7684\u6ce1\u6cab\u7ec6\u80de\u635f\u4f24\u3002\u5728\u897f\u65b9\u996e\u98df\u5582\u517b 1\u30013 \u548c 6 \u4e2a\u6708\u540e\u89c2\u5bdf\u5230\u66f4\u590d\u6742\u548c\u4e25\u91cd\u7684\u75c5\u53d8\uff08Lutgens \u7b49\uff0c1999\uff09\u3002<\/p>\n\n\n\n<p id=\"p0225\">ApoE3-Leiden \u5c0f\u9f20\u88ab\u7528\u4f5c\u6a21\u578b\u6765\u9610\u660e\u53c2\u4e0e ApoE \u4ee3\u8c22\u7684\u56e0\u7d20\uff0c\u7279\u522b\u662f\u5bb6\u65cf\u6027\u8840\u8102\u5f02\u5e38\u7684\u75c5\u56e0\u3002\u6b64\u5916\uff0cApoE3-Leiden \u5c0f\u9f20\u7528\u4e8e\u7814\u7a76\u9759\u8109\u65c1\u8def\u79fb\u690d\u672f\u7684\u5e76\u53d1\u75c7\uff0c\u8fd9\u662f\u4e00\u79cd\u7ed5\u8fc7\u52a8\u8109\u7ca5\u6837\u786c\u5316\u963b\u585e\u7684\u4e34\u5e8a\u7a0b\u5e8f\u3002\u4e0e\u4eba\u7c7b\u76f8\u4f3c\uff0c\u8be5\u6a21\u578b\u4e2d\u7684\u79fb\u690d\u9759\u8109\u4f1a\u53d1\u751f\u91cd\u5851\uff0c\u8fd9\u662f\u66b4\u9732\u4e8e\u8f83\u9ad8\u7684\u8840\u538b\u548c\u526a\u5207\u5e94\u529b\u7684\u7ed3\u679c\uff0c\u4e5f\u662f\u624b\u672f\u5bfc\u81f4\u7684\u8840\u7ba1\u635f\u4f24\u7684\u7ed3\u679c\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u5bfc\u81f4\u5185\u819c\u589e\u751f\u548c\u52a0\u901f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5f62\u6210\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u79fb\u690d\u7269\u963b\u585e\uff08de Vries \u7b49\u4eba\uff0c2016 \u5e74\uff0cKarper \u7b49\u4eba\uff0c2011 \u5e74\uff0cLutgens \u7b49\u4eba\uff0c1999 \u5e74\uff09\u3002<\/p>\n\n\n\n<p id=\"p0230\">\u7531\u4e8e\u53d1\u73b0\u9759\u8109\u79fb\u690d\u75c5\u53d8\u4e0e\u5929\u7136\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4e4b\u95f4\u5b58\u5728\u76f8\u4f3c\u6027\uff0c\u56e0\u6b64\u5efa\u7acb\u4e86\u9759\u8109\u79fb\u690d\u75be\u75c5\u7684\u5c0f\u9f20\u6a21\u578b\uff08Zou \u7b49\uff0c1998\uff09\u3002\u5728\u8be5\u6a21\u578b\u4e2d\uff0c\u5c06\u4f9b\u4f53\u5c0f\u9f20\u7684\u80f8\u8154\u9759\u8109\u79fb\u690d\u5230\u53d7\u4f53\u5c0f\u9f20\u7684\u9888\u52a8\u8109\u4e2d\u3002\u8be5\u7a0b\u5e8f\u5df2\u7528\u4e8e\u6613\u60a3\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5c0f\u9f20\uff08ApoE&nbsp;<sup>-\/-<\/sup>\u6216 ApoE3-Leiden \u5c0f\u9f20\uff09\uff0c\u56e0\u6b64\u53ef\u4ee5\u7814\u7a76\u52a0\u901f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u9759\u8109\u79fb\u690d\u7269(Dietrich et al., 2000; Lardenoye et al., 2002a, 2002b)\u3002\u5df2\u7ecf\u8868\u660e\uff0c\u8fd9\u4e9b\u8f6c\u57fa\u56e0\u5c0f\u9f20\u7684\u9759\u8109\u79fb\u690d\u7269\u5728\u5f62\u6001\u4e0a\u4e0e\u4eba\u7c7b\u6613\u7834\u88c2\u7684\u6591\u5757\u76f8\u4f3c\u3002\u8be5\u6a21\u578b\u75c5\u53d8\u5177\u6709\u5178\u578b\u7684\u665a\u671f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7279\u5f81\uff0c\u5305\u62ec\u5b58\u5728\u6ce1\u6cab\u7ec6\u80de\u3001\u5927\u574f\u6b7b\u6838\u5fc3\u3001\u6591\u5757\u5185\u65b0\u751f\u8840\u7ba1\u3001\u9499\u5316\u548c\u80c6\u56fa\u9187\u7ed3\u6676\uff08Lardenoye \u7b49\uff0c2000\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sect0045\">2.5&nbsp;.&nbsp;PCSK9-AAV \u5c0f\u9f20<\/h3>\n\n\n\n<p id=\"p0235\">\u9664\u4e0a\u8ff0\u6a21\u578b\u5916\uff0c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7814\u7a76\u9886\u57df\u6b63\u5728\u51fa\u73b0\u4e00\u79cd\u65b0\u7684\u65e0\u79cd\u7cfb\u57fa\u56e0\u5de5\u7a0b\u5c0f\u9f20\u6a21\u578b\u3002\u4e24\u4e2a\u7814\u7a76\u5c0f\u7ec4\u5728 2014 \u5e74\u72ec\u7acb\u63cf\u8ff0\u4e86\u6240\u8c13\u7684\u524d\u86cb\u767d\u8f6c\u5316\u9176\u67af\u8349\u6746\u83cc\u86cb\u767d\u9176\/kexin 9 \u578b (PCSK9) \u2013 \u817a\u76f8\u5173\u75c5\u6bd2 (AAV) \u5c0f\u9f20\uff0c\u4f5c\u4e3a\u4e00\u79cd\u5feb\u901f\u3001\u901a\u7528\u4e14\u5177\u6709\u6210\u672c\u6548\u76ca\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u52a8\u7269\u6a21\u578b (&nbsp;Bjorklund \u7b49\u4eba\u3002 \uff0c2014 \u5e74\uff0c\u7f57\u6c0f-\u83ab\u5229\u7eb3\u7b49\u4eba\uff0c2015 \u5e74\uff09\u3002PCSK9\u662f\u4e00\u79cd\u65b0\u53d1\u73b0\u7684\u4eba\u7c7b\u67af\u8349\u6746\u83cc\u9176\uff0c\u662f\u4e00\u79cd\u4e1d\u6c28\u9178\u86cb\u767d\u9176\uff0c\u8840\u6d46\u6d53\u5ea6\u7ea6\u4e3a 100 \u81f3 200&nbsp;&nbsp;ng\/mL\uff0c\u5728\u809d\u810f\u4e2d\u9ad8\u5ea6\u8868\u8fbe (&nbsp;Akram et al., 2010&nbsp;,&nbsp;Denis et al., 2012\uff09\u3002\u591a\u9879\u7814\u7a76\u8868\u660e\uff0cPCSK9 \u901a\u8fc7\u589e\u52a0 LDL \u53d7\u4f53\u7684\u5185\u4f53\u548c\u6eb6\u9176\u4f53\u964d\u89e3\u6765\u51cf\u5c11\u809d\u810f\u5bf9 LDL \u7684\u6444\u53d6\uff08Li et al., 2007&nbsp;\uff09\u3002\u7b80\u800c\u8a00\u4e4b\uff0c\u5728\u86cb\u767d\u8d28\u6210\u719f\u548c\u5206\u6ccc\u540e\uff0c\u5faa\u73af PCSK9 \u4e0e\u7ec6\u80de\u8868\u9762\u7684 LDL \u53d7\u4f53\u7ed3\u5408\uff0c\u968f\u540e\u4e0e\u53d7\u4f53\u5171\u540c\u5185\u5316\u3002\u8fd9\u5206\u6563\u4e86\u53d7\u4f53\u5411\u8d28\u819c\u7684\u6b63\u5e38\u5faa\u73af\u8fc7\u7a0b\uff0c\u5e76\u4fc3\u8fdb\u4e86\u6eb6\u9176\u4f53\u7684\u964d\u89e3\uff08Akram et al., 2010\uff09\u3002<\/p>\n\n\n\n<p id=\"p0240\">\u91cd\u7ec4AAV \u8f7d\u4f53\u652f\u6301\u5728\u8bb8\u591a\u52a8\u7269\u6a21\u578b\uff08 Cerrone \u7b49\u4eba\uff0c2012 \u5e74\uff0cKaspar \u7b49\u4eba\uff0c2005 \u5e74\uff0cSuhy \u7b49\u4eba\uff0c2012 \u5e74\uff09\u548c\u4eba\u7c7b\uff08Zsebo \u7b49\u4eba\uff0c2014 \u5e74\uff09\u4e2d\u7684\u957f\u671f\u8f6c\u57fa\u56e0\u8868\u8fbe\u3002\u5355\u6b21\u9759\u8109\u6ce8\u5c04\u4eba D374Y (&nbsp;Roche-Molina et al., 2015&nbsp;) \u6216\u9f20 D377Y (&nbsp;Bjorklund et al., 2014 ) \u529f\u80fd\u83b7\u5f97\u6027\u7a81\u53d8\u4f53 PCSK9 \u540e\uff0c\u5c0f\u9f20\u5728\u809d\u810f\u4e2d\u7a33\u5b9a\u8868\u8fbe PCSK9&nbsp;<sup>DY mRNA\u3002<\/sup>AAV\u75c5\u6bd2\u611f\u67d3\u4e0d\u4f1a\u5728\u52a8\u7269\u4e2d\u5f15\u8d77\u4efb\u4f55\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u4e14\u5728\u611f\u67d3\u540e\u6ca1\u6709\u89c2\u5bdf\u5230\u809d\u635f\u4f24\u6216\u514d\u75ab\u53cd\u5e94\u7684\u8ff9\u8c61\u3002\u6ce8\u5c04\u540e 30 \u5929\uff0cPCSK9 \u4e2d\u7684\u603b\u8840\u6e05\u80c6\u56fa\u9187<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/adeno-associated-virus\"><\/a>\u4e0e\u5bf9\u7167\u5c0f\u9f20\u76f8\u6bd4\uff0cDY -AAV \u8f6c\u57fa\u56e0\u589e\u52a0\u4e86\u4e00\u500d<sup>\u3002<\/sup>\u5373\u4f7f\u5728\u611f\u67d3 1 \u5e74\u540e\uff0c\u8fd9\u4e9b\u5dee\u5f02\u4ecd\u7136\u4fdd\u6301\u4e0d\u53d8\uff0c\u8fd9\u8bc1\u5b9e\u4e86\u5355\u6b21 AAV \u6ce8\u5c04\u7684\u6162\u6027\u5f71\u54cd\uff08Roche-Molina \u7b49\u4eba\uff0c2015 \u5e74\uff09\u3002\u897f\u5f0f\u996e\u98df\u52a0\u5267\u4e86 PCSK9&nbsp;<sup>DY<\/sup>&nbsp;-AAV \u5c0f\u9f20\u7684\u9ad8\u8102\u8840\u75c7\uff0c\u5bfc\u81f4\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u9ad8\u8fbe 1165&nbsp;&nbsp;mg\/dl\uff0c\u800c\u6b63\u5e38\u996e\u98df\u5582\u517b\u7684\u5c0f\u9f20\u51e0\u4e4e\u6ca1\u6709\u8fbe\u5230 316&nbsp;&nbsp;mg\/dl\u3002\u897f\u5f0f\u996e\u98df\u5582\u517b PCSK9&nbsp;<sup>DY<\/sup>&nbsp;-AAV \u5c0f\u9f20\u7684\u8102\u86cb\u767d\u8c31\u663e\u793a VLDL \u548c LDL \u9897\u7c92\u4e4b\u95f4\u7684\u5206\u5e03\u76f8\u7b49\uff08Roche-Molina \u7b49\u4eba\uff0c2015 \u5e74\uff09\u3002PCSK9&nbsp;<sup>DY<\/sup>\u8f6c\u57fa\u56e0\u5c0f\u9f20\u4ee5\u5242\u91cf\u4f9d\u8d56\u6027\u65b9\u5f0f\u53d1\u5c55\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3002\u9ad8\u8102\u8840\u75c7\u4f1a\u5728\u6574\u4e2a\u8109\u7ba1\u7cfb\u7edf\u4e2d\u5f15\u8d77\u7c7b\u4f3c\u4e8e LDLr&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u7684\u75c5\u53d8\u79ef\u805a\uff0c\u800c HFD \u5582\u517b\u4f1a\u52a0\u5267\u8fd9\u79cd\u60c5\u51b5\uff08Bjorklund \u7b49\u4eba\uff0c2014 \u5e74\uff0cRoche-Molina \u7b49\u4eba\uff0c2015 \u5e74\uff09\u3002\u4e3b\u52a8\u8109\u6839\u90e8\u75c5\u53d8\u663e\u793a\u6709\u6ce1\u6cab\u7ec6\u80de\u3001\u5e73\u6ed1\u808c\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u6d78\u6da6\u548c\u7ea4\u7ef4\u7ec4\u7ec7\u7684\u665a\u671f\u6591\u5757\u53d1\u5c55\uff0c\u4f46\u91cd\u8981\u7684\u662f\uff0c\u75c5\u53d8\u8fdb\u5c55\u5230\u7ea4\u7ef4\u7ca5\u6837\u786c\u5316\u9636\u6bb5\uff08Bjorklund \u7b49\u4eba\uff0c2014 \u5e74\uff0cRoche-Molina \u7b49\u4eba\uff0c2015 \u5e74\uff09\u548c\u5728 15-20 \u5468\u7684\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u53d1\u751f\u8840\u7ba1\u9499\u5316(&nbsp;Goettsch et al., 2016&nbsp;)\u3002\u5f53 Roche-Molina \u7b49\u4eba\u3002\u7ec4\u5408PCSK9<sup>DY<\/sup>\u8868\u8fbe\u548c ApoE \u7f3a\u4e4f\uff0c\u4ed6\u4eec\u63ed\u793a\u4e86\u9884\u671f\u7684\u534f\u540c\u6548\u5e94\uff1a\u4e0e\u76f8\u540c\u996e\u98df\u7684\u5355\u4e00\u7a81\u53d8\u4f53\u76f8\u6bd4\uff0c\u75c5\u53d8\u5927\u5c0f\u7ffb\u500d\uff0c\u8102\u86cb\u767d\u8c31\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff08Roche-Molina \u7b49\u4eba\uff0c2015 \u5e74\uff09\u3002<\/p>\n\n\n\n<p id=\"p0245\">\u603b\u4f53\u800c\u8a00\uff0c\u5728\u5177\u6709\u4e0d\u540c\u9057\u4f20\u80cc\u666f\u7684\u52a8\u7269\u4e2d\u8bf1\u5bfc\u9ad8\u8102\u8840\u75c7\u548c\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff0c\u5355\u6b21\u65bd\u7528\u7a81\u53d8\u4eba\u7c7b PCSK9 \u540e\u7684\u7a33\u5065\u7a33\u5b9a\u6027\u4ee5\u53ca\u4f7f\u7528 AAV \u4f5c\u4e3a\u8f7d\u4f53\u6ca1\u6709\u91cd\u5927\u751f\u7269\u5b89\u5168\u95ee\u9898\u7684\u4e8b\u5b9e\uff0c\u4f7f PCSK9-AAV \u6a21\u578b\u5728\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7814\u7a76\u4e2d\u6210\u4e3a\u6709\u4ef7\u503c\u7684\u5de5\u5177\uff08Roche-Molina \u7b49\u4eba\uff0c2015 \u5e74\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sect0050\">3&nbsp;.&nbsp;\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7834\u88c2\u7684\u5c0f\u9f20\u6a21\u578b<\/h2>\n\n\n\n<p id=\"p0250\">\u5c3d\u7ba1\u5fc3\u8111\u8840\u7ba1\u7814\u7a76\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\uff0c\u4f46\u6591\u5757\u7834\u88c2\u4ecd\u7136\u662f\u6025\u6027\u4e8b\u4ef6\u7684\u4e3b\u8981\u539f\u56e0\uff08Yl\u00e4-Herttuala \u7b49\u4eba\uff0c2011 \u5e74\uff09\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u6591\u5757\u7a33\u5b9a\u7597\u6cd5\u7684\u9700\u6c42\u5f88\u9ad8\u3002\u5728\u8fc7\u53bb\u7684 15 \u5e74\u4e2d\uff0c\u51e0\u4e2a\u7814\u7a76\u5c0f\u7ec4\u8bd5\u56fe\u5f00\u53d1\u5408\u9002\u7684\u6591\u5757\u7834\u88c2\u6a21\u578b\uff0c\u4f46\u5728\u8fd9\u4e9b\u6a21\u578b\u4e2d\uff0c\u7834\u88c2\u53ea\u662f\u5076\u5c14\u53d1\u751f\uff0c\u6216\u8005\u9700\u8981\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\uff0c\u6216\u8005\u53d6\u51b3\u4e8e\u673a\u68b0\u635f\u4f24\uff08Chen \u7b49\u4eba\uff0c2013 \u5e74\uff0cNi \u7b49\u4eba\u3002 \uff0c2009 \u5e74\uff0c\u65bd\u74e6\u8328\u7b49\u4eba\uff0c2007 \u5e74\uff09\u3002\u6b64\u5916\uff0c\u91cd\u73b0\u6027\u4f4e\uff0c\u5f88\u5c11\u89c2\u5bdf\u5230\u5728\u4eba\u7c7b\u8eab\u4e0a\u770b\u5230\u7684\u4e8b\u4ef6\u3002<\/p>\n\n\n\n<p id=\"p0255\">\u5982\u524d\u6240\u8ff0\uff0c\u5c0f\u9f20\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u53d1\u80b2\u4e8e\u7279\u5b9a\u90e8\u4f4d\uff0c\u4f8b\u5982\u4e3b\u52a8\u8109\u6839\u90e8\u3001\u4e3b\u52a8\u8109\u5f13\u5c0f\u5f2f\u4ee5\u53ca\u5934\u81c2\u52a8\u8109\u3001\u5de6\u9888\u52a8\u8109\u548c\u9501\u9aa8\u4e0b\u52a8\u8109\u7684\u5206\u652f\u70b9\u3002\u7136\u800c\uff0c\u5c0f\u9f20\u5728\u51a0\u72b6\u52a8\u8109\u548c\u9888\u52a8\u8109\u4e2d\u4ec5\u8868\u73b0\u51fa\u8f7b\u5fae\u7684\u6591\u5757\u53d1\u80b2\uff0c\u800c\u8fd9\u662f\u4eba\u7c7b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u53d1\u80b2\u7684\u4e3b\u8981\u90e8\u4f4d\uff08&nbsp;Bond \u548c Jackson\uff0c2011\uff0cGetz \u548c Reardon\uff0c2012\uff0cVanderLaan \u7b49\uff0c2004\uff09\u3002\u4e3a\u4e86\u8bf1\u5bfc\u5c0f\u9f20\u6591\u5757\u7834\u88c2\uff0c\u5df2\u7ecf\u63d0\u51fa\u4e86\u51e0\u79cd\u57fa\u4e8e\u624b\u672f\uff08\u5982\u52a8\u8109\u7ed3\u624e\u6216\u5c06\u624e\u5e26\u5b9a\u4f4d\u5728\u52a8\u8109\u5468\u56f4\uff09\u6216\u57fa\u56e0\u64cd\u4f5c\u7684\u65b9\u6cd5\uff08\u8868 1\uff09\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u6a21\u578b\u6709\u52a9\u4e8e\u7406\u89e3\u6591\u5757\u7834\u88c2\u7684\u6982\u5ff5\uff0c\u4f46\u5b83\u4eec\u90fd\u6ca1\u6709\u8868\u73b0\u51fa\u4eba\u7c7b\u6613\u635f\/\u7834\u88c2\u6591\u5757\u6240\u89c1\u7279\u5f81\u7684\u5b8c\u6574\u7ec4\u5408\u3002<a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/thrombus\"><\/a>\u6b64\u5916\uff0c\u5f88\u5c11\u89c2\u5bdf\u5230\u6591\u5757\u7834\u88c2\u4f34\u6709\u91cd\u53e0\u7684\u95ed\u585e\u6027\u8840\u6813\uff0c\u8fd9\u662f\u4eba\u7c7b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6700\u5e38\u89c1\u7684\u5e76\u53d1\u75c7\uff08 Bentzon \u548c Falk\uff0c2010 \u5e74\uff09\u3002<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/myocardial-infarction\"><\/a>\u56e0\u6b64\uff0c\u5728\u8fd9\u4e9b\u6a21\u578b\u4e2d\u51e0\u4e4e\u4ece\u672a\u89c1\u8fc7\u8bf8\u5982MI\u6216\u7f3a\u8840\u6027\u4e2d\u98ce\u4e4b\u7c7b\u7684\u4e34\u5e8a\u4e8b\u4ef6\uff08 Bond \u548c Jackson\uff0c2011 \u5e74\uff0c&nbsp;Yl\u00e4-Herttuala \u7b49\u4eba\uff0c2011 \u5e74\uff09\uff09\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u6a21\u578b\u4e2d\u7684\u5927\u591a\u6570\u90fd\u6ca1\u6709\u663e\u793a\u201c\u81ea\u53d1\u201d\u6591\u5757\u7834\u88c2\u3002\u5f53\u89c2\u5bdf\u5230\u81ea\u53d1\u7834\u88c2\u65f6\uff0c\u5b83\u4eec\u53ea\u662f\u5076\u5c14\u53d1\u751f\u5e76\u4e14\u5728\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\u540e\u53d1\u751f\u3002\u7136\u800c\uff0c\u6700\u8fd1\u5df2\u7ecf\u63cf\u8ff0\u4e86\u5c0f\u9f20\u4e2d\u4e00\u81f4\u7684\u3001\u81ea\u53d1\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7834\u88c2\u6a21\u578b\uff0c\u5982\u4e0b\u6240\u8ff0\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>\u62c9\u7d27<\/strong><\/th><th><strong>\u673a\u5236<\/strong><\/th><th><strong>\u6301\u7eed\u65f6\u95f4\uff08\u5468\uff09<\/strong><\/th><th><strong>\u6591\u5757\u7834\u574f<\/strong><\/th><th><strong>\u8154\u5185\u8840\u6813<\/strong><\/th><th><strong>\u6591\u5757\u5185\u65b0\u8840\u7ba1<\/strong><\/th><th><strong>IPH<\/strong><\/th><th><strong>\u5411\u5916\u91cd\u5851<\/strong><\/th><th><strong>\u201c\u7c7b\u4eba\u201d\u5e76\u53d1\u75c7<\/strong><\/th><th><strong>\u8bc4\u8bba<\/strong><\/th><th><strong>\u53c2\u8003\u3002<\/strong><\/th><\/tr><\/thead><tbody><tr><th>ApoE&nbsp;<sup>-\/-<\/sup><\/th><td>\u2018\u8001\u5316\u2019<\/td><td>60<\/td><td>12%<\/td><td>3%<\/td><td>ND<\/td><td>ND<\/td><td>ND<\/td><td>\u51a0\u72b6\u52a8\u8109\u8840\u6813\u5f62\u6210<\/td><td>\u957f\u671f\u5b9e\u9a8c<br>\u6591\u5757\u7834\u88c2\u548c\u8840\u6813\u5f62\u6210\u7387\u4f4e<\/td><td>\uff08\u5361\u62c9\u62c9\u7b49\u4eba\uff0c2001 \u5e74\uff09<\/td><\/tr><tr><th>ApoE&nbsp;<sup>-\/-<\/sup><\/th><td>\u6df7\u5408 C57BL\/6\u2013129SvJ \u80cc\u666f<\/td><td>30\u201365<\/td><td>52%<\/td><td>73%<\/td><td>ND<\/td><td>ND<\/td><td>ND<\/td><td>MI\uff08\u201c\u67d0\u4e9b\u60c5\u51b5\u201d\uff09\u731d\u6b7b<\/td><td>\u957f\u671f\u5b9e\u9a8c\u6df7\u5408\u80cc\u666f<\/td><td>\uff08\u5a01\u5ec9\u59c6\u65af\uff0c2002\uff09<\/td><\/tr><tr><th>ApoE&nbsp;<sup>-\/-<\/sup><\/th><td>\u9888\u5708\uff1aSMC<br>+ \u53bb\u6c27\u80be\u4e0a\u817a\u7d20\u4e2d\u7684 Ad-p53<\/td><td>15\u201317<\/td><td>40%<\/td><td>5%<\/td><td>ND<\/td><td>35%<\/td><td>ND<\/td><td>ND<\/td><td>\u6591\u5757\u7834\u88c2\u4e0d\u662f\u81ea\u53d1\u7684\uff0c\u64cd\u4f5c\u590d\u6742<\/td><td>\uff08\u51af\u5fb7\u82cf\u68ee\u7b49\u4eba\uff0c2002 \u5e74\uff09<\/td><\/tr><tr><th>ApoE&nbsp;<sup>-\/-<\/sup><\/th><td>M\u03c6 \u4e2d\u7684\u6d3b\u6027 MMP-9 \u8fc7\u8868\u8fbe<\/td><td>41<\/td><td>40%<\/td><td>\u7ea4\u7ef4\u86cb\u767d\u6c89\u79ef<br>(100%)<\/td><td>ND<\/td><td>90%<\/td><td>ND<\/td><td>\u731d\u6b7b<br>(20%)<\/td><td>\u957f\u671f\u5b9e\u9a8c\uff0c\u64cd\u4f5c\u590d\u6742<\/td><td>\uff08\u9ad8\u592b\u7b49\u4eba\uff0c2006 \u5e74\uff09<\/td><\/tr><tr><th>ApoE&nbsp;<sup>-\/-<\/sup><\/th><td>\u5957\u56ca\uff08+\u7ed3\u624e\uff09<\/td><td>13-14<\/td><td>29\u201363%<\/td><td>17\u201342%<\/td><td>ND<\/td><td>31\u201347%<\/td><td>ND<\/td><td>ND<\/td><td>\u6591\u5757\u7834\u88c2\u4e0d\u662f\u81ea\u53d1\u7684<\/td><td>\uff08\u4f50\u4f50\u6728\u7b49\u4eba\uff0c2006 \u5e74\uff09<\/td><\/tr><tr><th>ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;: TM&nbsp;<sup>Pro\/Pro<\/sup><\/th><td>\u9888\u5708\uff0c\u9057\u4f20\u6027\u9ad8\u51dd\u72b6\u6001<\/td><td>16\u201317<\/td><td>+<\/td><td>+<\/td><td>ND<\/td><td>+<\/td><td>+<\/td><td>ND<\/td><td>\u6591\u5757\u7834\u88c2\u4e0d\u662f\u81ea\u53d1\u7684<\/td><td>\uff08\u9c8d\u91cc\u7d22\u592b\u7b49\u4eba\uff0c2013 \u5e74\uff09<\/td><\/tr><tr><th>ApoE&nbsp;<sup>-\/-<\/sup><\/th><td>\u90e8\u5206\u7ed3\u624e\u9888\u52a8\u8109+\u80be\u52a8\u8109<\/td><td>16<\/td><td>+<\/td><td>50%<\/td><td>ND<\/td><td>80%<\/td><td>ND<\/td><td>ND<\/td><td>\u6591\u5757\u7834\u88c2\u4e0d\u662f\u81ea\u53d1\u7684<\/td><td>\uff08\u91d1\u7b49\u4eba\uff0c2012\uff09<\/td><\/tr><tr><th>ApoE&nbsp;<sup>-\/-<\/sup><\/th><td>M\u03c6\u4e2d\u7684uPA\u8fc7\u8868\u8fbe<\/td><td>43\u201348<\/td><td>78%<\/td><td>\u7ea4\u7ef4\u86cb\u767d\u6c89\u79ef (67%)<\/td><td>ND<\/td><td>61%<\/td><td>ND<\/td><td>ND<\/td><td>\u957f\u671f\u5b9e\u9a8c\uff0c\u64cd\u4f5c\u590d\u6742<\/td><td>\uff08\u80e1\u7b49\u4eba\uff0c2010\uff09<\/td><\/tr><tr><th>ApoE&nbsp;<sup>-\/-<\/sup><\/th><td>\u4e32\u8054\u72ed\u7a84<\/td><td>14-22<\/td><td>32%<\/td><td>+<\/td><td>+<\/td><td>50%<\/td><td>+<\/td><td>ND<\/td><td>\u6591\u5757\u7834\u88c2\u4e0d\u662f\u81ea\u53d1\u7684<\/td><td>\uff08\u9648\u7b49\u4eba\uff0c2013 \u5e74\uff09<\/td><\/tr><tr><th>ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup><\/th><td>\u5f39\u6027\u86cb\u767d\u788e\u7247<\/td><td>20\u201335<\/td><td>50\u201370%<\/td><td>\u9888\u52a8\u8109<\/td><td>+<\/td><td>90%<\/td><td>+<\/td><td>\u5fc3\u808c\u6897\u6b7b\u3001\u4e2d\u98ce\u3001\u731d\u6b7b<\/td><td>\u81ea\u53d1\u6027\u6591\u5757\u7834\u88c2<\/td><td>\uff08\u8303\u5fb7\u5510\u514b\u7279\u7b49\u4eba\uff0c2015b\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u663e\u793a\u8be6\u7ec6\u4fe1\u606f<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sect0055\">3.1&nbsp;.&nbsp;\u8f7d\u8102\u86cb\u767d E \u7f3a\u9677 Fibrillin-1 \u7a81\u53d8\u4f53 (ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>&nbsp;) \u5c0f\u9f20<\/h3>\n\n\n\n<p id=\"p0260\">\u7ec6\u80de\u5916\u57fa\u8d28\u662f\u4e3b\u8981\u7531\u5f39\u6027\u86cb\u767d\u548c\u80f6\u539f\u86cb\u767d\u7ec4\u6210\u7684\u590d\u6742\u7f51\u7edc\uff0c\u8fd9\u5bf9\u4e8e\u4e3a\u8840\u7ba1\u58c1\u63d0\u4f9b\u7ed3\u6784\u3001\u7c98\u9644\u548c\u751f\u5316\u4fe1\u53f7\u652f\u6301\u81f3\u5173\u91cd\u8981\u3002\u5728\u5f39\u6027\u52a8\u8109\u4e2d\uff0c\u5f39\u6027\u86cb\u767d\u662f\u6700\u4e30\u5bcc\u7684\u86cb\u767d\u8d28\u3002\u5f39\u6027\u7ea4\u7ef4\u5305\u542b\u5f39\u6027\u86cb\u767d\u6838\u5fc3\uff0c\u5f39\u6027\u86cb\u767d\u6838\u5fc3\u88ab\u5bcc\u542b\u539f\u7ea4\u7ef4\u86cb\u767d\u7684\u5fae\u7ea4\u7ef4\u5305\u88f9\uff08Kielty et al., 2002&nbsp;\uff09\u3002\u4e0e\u5f39\u6027\u7ea4\u7ef4\u76f8\u5173\u7684\u5fae\u7ea4\u7ef4\u7684\u4e3b\u8981\u7ed3\u6784\u6210\u5206\u662f\u539f\u7ea4\u7ef4\u86cb\u767d-1\uff0c\u8fd9\u662f\u4e00\u79cd\u7ea6 350 kDa \u7684\u5927\u7cd6\u86cb\u767d&nbsp;\uff0c\u5176\u4e3b\u8981\u4f5c\u7528\u662f\u7ed3\u5408\u548c\u9694\u79bb\u751f\u957f\u56e0\u5b50\uff0c\u5982\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2 (TGF-\u03b2)\uff0c\u5982\u4ee5\u53ca\u4e3a\u5f39\u6027\u86cb\u767d\u7684\u6c89\u79ef\u548c\u4ea4\u8054\u63d0\u4f9b\u652f\u67b6\uff08(Judge and Dietz, 2005; Van Herck et al., 2009\uff09\u3002<\/p>\n\n\n\n<p id=\"p0265\">\u6700\u8fd1\uff0c\u6211\u4eec\u901a\u8fc7\u5c06 Apo<sup>E -\/-<\/sup>\u5c0f\u9f20\u4e0efibrillin-1 (Fbn1) \u57fa\u56e0\u4e2d\u542b\u6709\u6742\u5408\u7a81\u53d8 (C1039G&nbsp;<sup>+\/-<\/sup>&nbsp;) \u7684\u5c0f\u9f20\u6742\u4ea4\uff0c\u62a5\u9053\u4e86\u8840\u7ba1\u58c1\u5f39\u6027\u86cb\u767d\u7ed3\u6784\u53d7\u635f\u5bf9\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8fdb\u5c55\u7684\u5f71\u54cd\u3002(Van Herck et al., 2009\uff09\u3002Fbn1 \u57fa\u56e0\u7684\u7a81\u53d8\u5bfc\u81f4\u9a6c\u51e1\u7efc\u5408\u5f81\uff0c\u8fd9\u662f\u4e00\u79cd\u4ee5\u5f39\u6027\u7ea4\u7ef4\u65ad\u88c2\u4e3a\u7279\u5f81\u7684\u9057\u4f20\u75be\u75c5\uff08Judge et al., 2004\uff09\u3002\u8fd9\u4f1a\u5bfc\u81f4\u52a8\u8109\u786c\u5316\u589e\u52a0\u3001\u8109\u538b\u5347\u9ad8\u548c\u8fdb\u884c\u6027\u4e3b\u52a8\u8109\u6269\u5f20\uff08Mariko et al., 2011&nbsp;,&nbsp;Medley et al., 2002&nbsp;,&nbsp;Van Herck et al., 2009\uff09\u3002\u6b64\u5916\uff0c\u8be5\u7a81\u53d8\u5bfc\u81f4 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u4e2d\u51fa\u73b0\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u7684\u6591\u5757\uff0c\u5bfc\u81f4\u81ea\u53d1\u6027\u6591\u5757\u7834\u88c2\uff0c\u7ec8\u70b9\u5305\u62ec MI \u548c\u731d\u6b7b\uff08Van der Donckt \u7b49\u4eba\uff0c2015b\uff0cVan Herck \u7b49\u4eba\uff0c2009 \u5e74\uff09\uff09\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u4e8b\u4ef6\u4e0d\u4f1a\u6216\u8005\u53ea\u662f\u975e\u5e38\u5076\u5c14\u53d1\u751f\u5728\u91c7\u7528\u897f\u65b9\u996e\u98df\u7684 ApoE&nbsp;<sup>-\/-&nbsp;<\/sup>\u5c0f\u9f20\u6216\u5582\u98df\u6b63\u5e38\u996e\u98df\u7684 ApoE&nbsp;<sup>-\/-&nbsp;<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u4e2d\uff08&nbsp;Van der Donckt et al., 2015a&nbsp;,&nbsp;Van der Donckt \u7b49\u4eba\uff0c2015b\uff09\u3002\u8fd9\u4e9b\u53d1\u73b0\u5f3a\u8c03\u4e86\u5f39\u6027\u86cb\u767d\u788e\u88c2\u4e0e\u897f\u65b9\u996e\u98df\u76f8\u7ed3\u5408\u4f5c\u4e3a\u5c0f\u9f20\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7834\u88c2\u7684\u5148\u51b3\u6761\u4ef6\u7684\u91cd\u8981\u6027\u3002<\/p>\n\n\n\n<p id=\"p0270\">ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u5177\u6709\u660e\u663e\u8f83\u5927\u7684\u6591\u5757\uff0c\u5177\u6709\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u7684\u8868\u578b\uff0c\u5176\u7279\u5f81\u662f\u8f83\u5927\u7684\u574f\u6b7b\u6838\u5fc3\uff08\u5360\u6591\u5757\u603b\u9762\u79ef\u7684\u7ea6 30%\uff09\uff0c\u5e76\u4e14\u80f6\u539f\u86cb\u767d\u542b\u91cf\u5f3a\u70c8\u51cf\u5c11\u3002\u8fd9\u4e9b\u5c0f\u9f20\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u52a0\u901f\u53ef\u80fd\u662f\u8840\u7ba1\u708e\u75c7\u589e\u5f3a\u7684\u7ed3\u679c\uff0c\u5bfc\u81f4<a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/vasculitis\"><\/a>\u5355\u6838\u7ec6\u80de\u5438\u5f15\u3001\u6c27\u5316\u548c\u8102\u8d28\u79ef\u7d2f\u589e\u52a0\uff08Fulop \u7b49\uff0c2005&nbsp;\uff09\u3002\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176(iNOS) \u662f\u6d3b\u5316\u5de8\u566c\u7ec6\u80de\u548c\u708e\u75c7\u7684\u6807\u5fd7\u7269\uff0c\u5728 ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u7684\u6591\u5757\u4e2d\u8868\u8fbe\u66f4\u591a\u897f\u65b9\u996e\u98df\u6216\u6b63\u5e38\u996e\u98df\u7684\u5c0f\u9f20\u4e0e\u897f\u65b9\u996e\u98df\u7684 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u76f8\u6bd4\u3002\u56e0\u6b64\uff0c\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff08TNF-\u03b1\uff09\u3001\u767d\u7ec6\u80de\u4ecb\u7d20-1\u03b2\uff08IL-1\u03b2\uff09\u548c\u767d\u7ec6\u80de\u4ecb\u7d206\uff08IL-6\uff09\u9ad8\u5ea6\u589e\u52a0\u3002\u6b64\u5916\uff0c\u5b58\u5728\u8f83\u9ad8\u7684 T \u7ec6\u80de\u6d78\u6da6\u53ca\u5176\u6fc0\u6d3b\u6807\u5fd7\u7269\u5e72\u6270\u7d20-\u03b3 (IFN-\u03b3)\uff0c\u540e\u8005\u901a\u8fc7\u6291\u5236 SMC \u5408\u6210\u80f6\u539f\u86cb\u767d\u5728\u80f6\u539f\u86cb\u767d\u8f6c\u6362\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u8fd9\u662f\u4fee\u590d\u548c\u7ef4\u6301\u7ea4\u7ef4\u5e3d\u6240\u5fc5\u9700\u7684\u5b8c\u6574\u6027\uff08Koenig \u548c Khuseyinova\uff0c2007 \u5e74\uff0cLibby\uff0c2013 \u5e74\uff09\u3002\u6b64\u5916\uff0c\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176 (MMP)-2\u3001-9\u3001-12 \u548c -13 \u5728 ApoE<sup>&nbsp;-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u4e2d\u7684\u8868\u8fbe\u6216\u6d3b\u6027\u589e\u52a0\u8001\u9f20\u3002MMP-2 \u548c MMP-9 \u4e0e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u548c\u8840\u7ba1\u751f\u6210\u6709\u5173\uff08Raffetto \u548c Khalil\uff0c2008 \u5e74\uff09\u3002\u4f8b\u5982\uff0c\u7f3a\u4e4f MMP-2 \u7684 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u4f1a\u5f62\u6210\u66f4\u5c0f\u3001\u66f4\u7a33\u5b9a\u7684\u6591\u5757\uff0c\u800c\u8fc7\u5ea6\u8868\u8fbe\u6d3b\u6027 MMP-9 \u7684\u5de8\u566c\u7ec6\u80de\u4f1a\u4fc3\u8fdb\u65b0\u8840\u7ba1\u5f62\u6210\u3001\u6591\u5757\u5185\u51fa\u8840\uff08de Nooijer \u7b49\u4eba\uff0c2005 \u5e74\uff0cGough \u7b49\u4eba\uff0c2006 \u5e74\uff09\u548cApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u6591\u5757\u7834\u88c2\u7684\u7279\u5f81(&nbsp;Gough et al., 2006\uff09\u3002\u5728\u540e\u4e00\u79cd\u60c5\u51b5\u4e0b\uff0c\u8fd9\u4e9b\u7279\u5f81\u5f52\u56e0\u4e8e\u5f39\u6027\u86cb\u767d\u964d\u89e3\uff0c\u5f3a\u8c03\u4e86\u5176\u5728\u6591\u5757\u4e0d\u7a33\u5b9a\u548c\u7834\u88c2\u4e2d\u7684\u4f5c\u7528\u3002MMP-12 \u548c MMP-13 \u8fd8\u5206\u522b\u6709\u52a9\u4e8e\u5f39\u6027\u86cb\u767d\u548c\uff08I \u578b\uff09\u80f6\u539f\u86cb\u767d\u964d\u89e3\u3002\u603b\u4e4b\uff0c\u5728\u897f\u5f0f\u996e\u98df\u7684 ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u4e2d\uff0c\u589e\u5f3a\u7684\u80f6\u539f\u86cb\u767d\/\u7ec6\u80de\u5916\u57fa\u8d28\u5206\u89e3\u4ee5\u53ca\u5408\u6210\u548c\u4fee\u590d\u51cf\u5c11\u53ef\u80fd\u662f\u5bfc\u81f4\u7ea4\u7ef4\u5e3d\u51cf\u5f31\u5e76\u4f7f\u5176\u66f4\u5bb9\u6613\u7834\u88c2\u7684\u539f\u56e0 (Libby, 2013; Raffetto and Khalil, 2008)\u3002<\/p>\n\n\n\n<p id=\"p0275\">\u4f7f\u7528\u897f\u65b9\u578b\u996e\u98df\u7684ApoE<sup>-\/-<\/sup>Fbn1<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u7684\u5934\u81c2\u52a8\u8109\u548c\u9888\u603b\u52a8\u8109\u6301\u7eed\u53d1\u751f\u5e7f\u6cdb\u7684\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u548c\u6591\u5757\u5185\u51fa\u8840\u3002\u8fd9\u4e9b\u7279\u5f81\u5728\u5c0f<a href=\"https:\/\/www.shuyudiet.com\/tag\/166\">\u9f20\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6a21\u578b<\/a>\u4e2d\u5f88\u5c11\u89c1\uff0c\u4f46\u5df2\u77e5\u5176\u9ad8\u5ea6\u5f71\u54cd\u4eba\u7c7b\u7684\u6591\u5757\u7684\u8fdb\u5c55\u548c\u8106\u5f31\u6027(Virmanietal.\uff0c2005)\u3002\u5728\u91c7\u7528\u897f\u5f0f\u996e\u98df\u7684ApoE-\/-Fbn1C1039G+\/-\u5c0f\u9f20\u4e2d\uff0c\u53ef\u80fd\u7531\u5916\u819c\u8840\u7ba1\u5f15\u8d77\u7684\u6591\u5757\u5185\u65b0\u8840\u7ba1\u660e\u663e\u4ece\u4ecb\u8d28\u4e2d\u51fa\u73b0\uff08Moulton et al., 2004; Rademakers et al., 2013\uff09\u3002\u65b0\u8840\u7ba1\u4e0d\u4ec5\u5b58\u5728\u4e8e\u6591\u5757\u7684\u5e95\u90e8\uff0c\u800c\u4e14\u8fd8\u7ecf\u5e38\u5728\u5176\u4e2d\u5fc3\u89c2\u5bdf\u5230\uff0c\u7c7b\u4f3c\u4e8e\u4eba\u7c7b\u75c5\u7406\uff08Rademakers et al., 2013; Virmani et al., 2005\uff09\u3002\u8840\u7ba1\u751f\u6210\u9700\u8981\u901a\u8fc7\u5305\u62ec\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u5728\u5185\u7684\u86cb\u767d\u9176\u964d\u89e3\u7ec6\u80de\u5916\u57fa\u8d28\uff0c\u4ee5\u4f7f\u5185\u76ae\u7ec6\u80de\u8fc1\u79fb\u5230\u5468\u56f4\u7ec4\u7ec7(Raffetto\u548cKhalil\uff0c2008)\u3002\u6b64\u5916\uff0c\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u964d\u89e3\u8bf1\u5bfc\u9694\u79bb\u7684\u8840\u7ba1\u751f\u6210\u56e0\u5b50\uff0c\u5982\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50 (VEGF) \u548c TGF-\u03b2 \u7684\u91ca\u653e\uff08de Nooijer \u7b49\u4eba\uff0c2005 \u5e74\uff0cRaffetto \u548c Khalil\uff0c2008 \u5e74\uff09\uff0c\u4e5f\u5728\u897f\u5f0f\u996e\u98df\u7684ApoE<sup>-\/-<\/sup>&nbsp;fbn1<sup>c1039g +\/-<\/sup>\u5c0f\u9f20\u4e2d\u89c2\u5bdf\u5230\u3002ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u7684\u65b0\u8840\u7ba1\u5f62\u6210\u7a0b\u5ea6\u4e0e\u8840\u7ba1\u58c1\u5f39\u6027\u86cb\u767d\u788e\u88c2\u7a0b\u5ea6\u76f8\u5173\u3002\u7136\u800c\uff0c\u4ec5\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u964d\u89e3\u4e0d\u8db3\u4ee5\u5728\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u4e2d\u8bf1\u5bfc\u65b0\u8840\u7ba1\u5f62\u6210\uff0c\u56e0\u4e3a\u5728\u6b63\u5e38\u996e\u98df\u7684 ApoE&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/microvessel\"><\/a><sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u7684<a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/hypoxia\"><\/a>\u6591\u5757\u4e2d\u4e0d\u5b58\u5728\u5fae\u8840\u7ba1\u3002\u8fd9\u4e00\u89c2\u5bdf\u7ed3\u679c\u8868\u660e\u9700\u8981\u4e00\u4e2a\u989d\u5916\u7684\u56e0\u7d20\u6765\u89e6\u53d1\u6591\u5757\u65b0\u8840\u7ba1\u5f62\u6210\u3002\u7f3a\u6c27\u662f\u4e00\u79cd\u4f17\u6240\u5468\u77e5\u7684\u8840\u7ba1\u751f\u6210\u89e6\u53d1\u56e0\u7d20 (&nbsp;Sluimer et al., 2009&nbsp;)\uff0c\u5b83\u4f7f\u5728\u897f\u5f0f\u996e\u98df\u9972\u5582\u7684 ApoE&nbsp;<sup>-\/-<\/sup>Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u7684\u5934\u81c2\u548c\u9888\u52a8\u8109\u4e2d\u6591\u5757\u663e\u8457\u589e\u52a0\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5347\u4e3b\u52a8\u8109\u7684\u7f3a\u6c27\u8f83\u5c0f\uff0c\u8fd9\u53ef\u80fd\u89e3\u91ca\u4e86\u8be5\u90e8\u4f4d\u7684\u65b0\u8840\u7ba1\u7684\u7f3a\u5931\u3002\u56e0\u6b64\uff0c\u5728\u897f\u65b9\u578b\u996e\u98df\u7684ApoE<sup>-\/-<\/sup>Fbn1<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u4e2d\uff0c\u9ad8\u6e17\u900f\u6027\u52a8\u8109\u58c1\u7684\u964d\u89e3\u3001\u7ec6\u80de\u5916\u57fa\u8d28\u548c\u6591\u5757\u5185\u7f3a\u6c27\u4f3c\u4e4e\u662f\u65b0\u8840\u7ba1\u5f62\u6210\u6240\u5fc5\u9700\u7684\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u65b0\u8840\u7ba1\u662f\u9ad8\u5ea6\u6cc4\u6f0f\u7684\u3002\u6b64\u5916\uff0c\u5728\u6591\u5757\u5e95\u90e8\u7684\u65b0\u8840\u7ba1\u9644\u8fd1\u5b58\u5728\u6591\u5757\u5185\u7ea2\u7ec6\u80de\uff0c\u8868\u660e\u6591\u5757\u5185\u51fa\u8840\uff0c\u8bc1\u5b9e\u65b0\u8840\u7ba1\u7834\u88c2\u662f\u6591\u5757\u5185\u51fa\u8840\u7684\u6765\u6e90\uff08de Nooijer \u7b49\u4eba\uff0c2005 \u5e74\uff0cKockx \u7b49\u4eba., 2003 \u5e74,Virmani \u7b49\u4eba\uff0c2005 \u5e74\uff09\u3002\u7ea2\u7ec6\u80de\u662f\u6e38\u79bb\u80c6\u56fa\u9187\u7684\u91cd\u8981\u6765\u6e90\uff0c\u56e0\u6b64\u4f1a\u589e\u52a0\u574f\u6b7b\u6838\u5fc3\u7684\u5927\u5c0f\u3002\u56e0\u6b64\uff0c\u65b0\u8840\u7ba1\u5f62\u6210\u9664\u4e86\u4e3a\u6591\u5757\u63d0\u4f9b\u767d\u7ec6\u80de\u548c\u8102\u86cb\u767d\u5916\uff0c\u8fd8\u53ef\u4ee5\u5728\u5fae\u8840\u7ba1\u7834\u88c2\u6216\u8840\u6813\u5f62\u6210\u65f6\u4fc3\u8fdb\u5c40\u7076\u6027\u6591\u5757\u6269\u5f20\uff08Kockx \u7b49\u4eba\uff0c2003 \u5e74\uff0cSluimer \u7b49\u4eba\uff0c2009 \u5e74\uff0cVirmani \u7b49\u4eba\uff0c2005 \u5e74\uff09\u3002\u603b\u4e4b\uff0c\u5728\u8fd9\u4e2a\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\u7b26\u5408\u5f53\u524d\u4eba\u7c7b\u6613\u635f\u6591\u5757\u7684\u6982\u5ff5\u3002<\/p>\n\n\n\n<p id=\"p0280\">\u9664\u4e86\u589e\u5f3a\u7684\u6591\u5757\u6613\u635f\u6027\u5916\uff0c\u6591\u5757\u7834\u88c2\u59cb\u7ec8\u5b58\u5728\u4e8e\u91c7\u7528\u897f\u65b9\u996e\u98df\u7684 ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u4e2d\uff0c\u4f46\u5f88\u5c11\u51fa\u73b0\u5728\u91c7\u7528\u897f\u65b9\u996e\u98df\u7684 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u4e2d\u3002\u6b64\u5916\uff0c\u5bcc\u542b\u7ea4\u7ef4\u86cb\u767d\u7684\u9644\u58c1\u8840\u6813\u5b58\u5728\u4e8e\u5934\u81c2\u52a8\u8109\u3001\u9888\u52a8\u8109\u548c\u51a0\u72b6\u52a8\u8109\u4ee5\u53ca\u5347\u4e3b\u52a8\u8109\u4e2d\u3002\u5185\u5728\u56e0\u7d20\uff08\u5373\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u7684\u6591\u5757\u8868\u578b\uff09\u548c\u5916\u5728\u56e0\u7d20\uff08\u5373\u4f5c\u7528\u5728\u6591\u5757\u4e0a\u7684\u529b\uff09\u90fd\u662f\u6591\u5757\u7834\u88c2\u7684\u57fa\u672c\u56e0\u7d20\uff08Slager \u7b49\u4eba\uff0c2005 \u5e74\uff09\uff09\u3002\u901a\u5e38\uff0c\u5f53\u65bd\u52a0\u5728\u7ea4\u7ef4\u5e3d\u4e0a\u7684\u673a\u68b0\u5e94\u529b\u8d85\u8fc7\u5176\u6297\u62c9\u5f3a\u5ea6\u65f6\uff0c\u5c31\u4f1a\u53d1\u751f\u7834\u88c2\u3002\u540e\u8005\u4e3b\u8981\u7531\u6591\u5757\u4e2d\u7684\u80f6\u539f\u86cb\u767d\u542b\u91cf\u51b3\u5b9a\uff0c\u5728\u897f\u5f0f\u996e\u98df\u7684 ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u7684\u6591\u5757\u4e2d\uff0c\u80f6\u539f\u86cb\u767d\u542b\u91cf\u663e\u7740\u964d\u4f4e\uff08&nbsp;Libby, 2013&nbsp;,&nbsp;Slager et al., 2005\uff09\u3002\u5347\u9ad8\u7684\u8109\u538b\uff08\u4f5c\u4e3a\u52a8\u8109\u786c\u5316\u7684\u7ed3\u679c\uff09\uff08Van Herck \u7b49\u4eba\uff0c2009 \u5e74\uff09\u5bfc\u81f4\u53cd\u590d\u7684\u6591\u5757\u53d8\u5f62\uff0c\u589e\u52a0\u4e86\u5e3d\u4e0a\u7684\u62c9\u4f38\u5e94\u529b\uff08Huang \u7b49\u4eba\uff0c2013 \u5e74\uff0cMedley \u7b49\u4eba\uff0c2002 \u5e74\uff09\u3002\u5f53\u957f\u671f\u4f7f\u7528\u65f6\uff0c\u8fd9\u4f1a\u5bfc\u81f4\u6591\u5757\u75b2\u52b3\uff0c\u4f7f\u5176\u5bb9\u6613\u7834\u88c2\uff08Huang et al., 2013&nbsp;,Slager \u7b49\u4eba\uff0c2005 \u5e74\uff09\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u8fdb\u884c\u6027\u4e3b\u52a8\u8109\u6269\u5f20\u548c\u5411\u5916\u91cd\u5851\uff08\u7531\u4e8e\u5927\u6591\u5757\uff09\uff0c\u5e3d\u7684\u80f6\u539f\u86cb\u767d\u548c\u5f39\u6027\u86cb\u767d\u7ea4\u7ef4\u88ab\u62c9\u4f38\u5e76\u53d8\u5f97\u66f4\u52a0\u575a\u786c\uff0c\u4ece\u800c\u589e\u52a0\u4e86\u5bf9\u673a\u68b0\u5e94\u529b\u7684\u654f\u611f\u6027\u3002ApoE<sup>&nbsp;-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u5347\u4e3b\u52a8\u8109\u7684\u4e3b\u52a8\u8109\u6269\u5f20\u975e\u5e38\u660e\u663e\uff0c\u8fd9\u8868\u660e\u8fd9\u79cd\u673a\u5236\u662f\u5bfc\u81f4\u8be5\u90e8\u4f4d\u4e0d\u7a33\u5b9a\u6591\u5757\u7834\u88c2\u7684\u539f\u56e0\u3002\u5728\u5934\u81c2\u52a8\u8109\u548c\u9888\u52a8\u8109\u4e2d\uff0c\u6591\u5757\u5185\u65b0\u8840\u7ba1\u5f62\u6210\u548c\u51fa\u8840\u7ecf\u5e38\u51fa\u73b0\uff0c\u8fdb\u4e00\u6b65\u589e\u52a0\u6591\u5757\u5927\u5c0f\u548c\u6613\u7834\u88c2\u6027\u3002<\/p>\n\n\n\n<p id=\"p0285\">\u6b64\u5916\uff0c\u5728\u897f\u5f0f\u996e\u98df\u7684 ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u4e2d\u89c2\u5bdf\u5230\u731d\u6b7b\uff0c\u4e3b\u8981\u5728 16 \u81f3 23 \u5468\u4e4b\u95f4\uff0c20 \u5468\u540e\u6b7b\u4ea1\u7387\u4e3a 50%\u3002\u6b64\u5916\uff0c\u4e0e\u5e78\u5b58\u8005\u76f8\u6bd4\uff0c\u7a81\u7136\u6b7b\u4ea1\u7684\u897f\u5f0f\u996e\u98df\u7684ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u7684\u51a0\u72b6\u52a8\u8109\u72ed\u7a84\u9891\u7387\u663e\u8457\u5347\u9ad8\uff0c\u8fd9\u8868\u660e\u51a0\u72b6\u52a8\u8109\u6591\u5757\u7684\u5b58\u5728\u5728\u5fc3\u6e90\u6027\u6b7b\u4ea1\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002\u5927\u591a\u6570 ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup><a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/coronary-artery-obstruction\"><\/a>\u897f\u5f0f\u996e\u98df\u7684\u5c0f\u9f20\u51fa\u73b0\u6897\u585e\u533a\u57df\uff0c\u8fd9\u5bf9\u5fc3\u810f\u529f\u80fd\u7684\u5f71\u54cd\u66f4\u5927\u3002\u867d\u7136\u4e0d\u77e5\u9053\u6897\u6b7b\u9762\u79ef\u589e\u52a0\u662f\u6591\u5757\u7834\u88c2\u7684\u7ed3\u679c\u8fd8\u662f\u7531\u4e8e\u660e\u663e\u7684\u6591\u5757\u5f62\u6210\u548c\u51a0\u72b6\u52a8\u8109\u72ed\u7a84\uff0c\u4f46\u8fd9\u4e9b\u53d1\u73b0\u662f\u663e\u8457\u7684\uff0c\u56e0\u4e3a\u5728\u897f\u65b9\u996e\u98df\u9972\u5582\u4e0b\u7684 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u4e2d\u51e0\u4e4e\u4ece\u672a\u51fa\u73b0\u51a0\u72b6\u52a8\u8109\u6591\u5757\u548c\u81ea\u53d1\u6027\u5fc3\u808c\u6897\u6b7b\u3002\u540c\u6837\u5728\u4eba\u7c7b\u4e2d\uff0cfibrillin-1 \u57fa\u56e0\u578b\u7684\u5dee\u5f02\u5df2\u663e\u793a\u6781\u5927\u5730\u5f71\u54cd\u6591\u5757\u8fdb\u5c55\u548c\u51a0\u72b6\u52a8\u8109\u75be\u75c5\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u5f3a\u8c03\u4e86 fibrillin-1 \u7a81\u53d8\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\u4e2d\u7684\u75c5\u7406\u751f\u7406\u5b66\u76f8\u5173\u6027\uff08Medley \u7b49\uff0c2002\uff09\u3002<\/p>\n\n\n\n<p id=\"p0290\">\u56e0\u6b64\uff0c\u5f39\u6027\u86cb\u767d\u788e\u88c2\u4e0e\u897f\u65b9\u996e\u98df\u76f8\u7ed3\u5408\u4f1a\u5bfc\u81f4 ApoE&nbsp;<sup>-\/-<\/sup>\u5c0f\u9f20\u7684\u6591\u5757\u4e0d\u7a33\u5b9a\u548c\u7834\u88c2\u3002ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u8868\u73b0\u51fa\u4eba\u7c7b\u7ec8\u672b\u671f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u8bb8\u591a\u7279\u5f81\uff0c\u4f8b\u5982\u6269\u5927\u7684\u574f\u6b7b\u6838\u5fc3\u3001\u5177\u6709\u91cd\u8981\u80f6\u539f\u7ea4\u7ef4\u635f\u5931\u7684\u8584\u7ea4\u7ef4\u5e3d\u3001\u5916\u5728\u91cd\u5851\u4ee5\u53ca\u6591\u5757\u5185\u5fae\u8840\u7ba1\u548c\u51fa\u8840\u7684\u5b58\u5728\uff0c\u5bfc\u81f4\u6591\u5757\u7834\u88c2\u3001\u5fc3\u808c\u6897\u6b7b\u548c\u731d\u6b7b\u3002\u56e0\u6b64\uff0cApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u897f\u5f0f\u996e\u98df\u7684\u5c0f\u9f20\u63d0\u4f9b\u4e86\u7814\u7a76\u53c2\u4e0e\u6591\u5757\u4e0d\u7a33\u5b9a\u7684\u5173\u952e\u56e0\u7d20\u7684\u673a\u4f1a\uff0c\u5305\u62ec\u6591\u5757\u5185\u65b0\u8840\u7ba1\u5f62\u6210\uff0c\u8fd9\u5c06\u63d0\u4f9b\u5bf9\u6591\u5757\u7834\u574f\u673a\u5236\u548c\u6cbb\u7597\u5e72\u9884\u6f5c\u5728\u76ee\u6807\u7684\u66f4\u591a\u89c1\u89e3\uff08Roth \u7b49\u4eba\u3002 , 2015a&nbsp;,&nbsp;Roth \u7b49\u4eba, 2016&nbsp;,&nbsp;Roth \u7b49\u4eba, 2015b&nbsp;,&nbsp;Van der Donckt \u7b49\u4eba, 2015b&nbsp;)\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sect0060\">4&nbsp;.&nbsp;\u5154\u5b50<\/h2>\n\n\n\n<p id=\"p0295\">\u5154\u5b50\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7814\u7a76\u4e2d\u6700\u5e38\u7528\u7684\u52a8\u7269\u4e4b\u4e00\uff0c\u56e0\u4e3a\u5b83\u4eec\u6613\u4e8e\u64cd\u4f5c\u4e14\u7ef4\u62a4\u6210\u672c\u76f8\u5bf9\u4f4e\u5ec9\uff08Getz \u548c Reardon\uff0c2012 \u5e74\uff09\u3002\u7136\u800c\uff0c\u81ea 2000 \u5e74\u4ee5\u6765\uff0c\u4f7f\u7528\u8fd9\u79cd\u52a8\u7269\u6a21\u578b\u7684\u8d8b\u52bf\u6709\u6240\u51cf\u5c11\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8eApoE\u548cLDL\u53d7\u4f53\u6572\u9664\u5c0f\u9f20\u5177\u6709\u66f4\u65b9\u4fbf\u7684\u53ef\u7528\u6027\uff08Fan et al., 2015&nbsp;\uff09\u3002\u591a\u79cd\u65b9\u6cd5\u548c\u6a21\u578b\u5df2\u88ab\u7528\u4e8e\u7814\u7a76\u5154\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53ca\u5176\u5e76\u53d1\u75c7\uff0c\u5305\u62ec\u9057\u4f20\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u5154\uff0c\u5982Watanabe \u9057\u4f20\u6027\u9ad8\u8102\u8840\u75c7\u5154(WHHL) (&nbsp;Watanabe, 1980&nbsp;)\u3001\u5582\u98df\u5bcc\u542b\u80c6\u56fa\u9187\u996e\u98df\u7684\u65b0\u897f\u5170\u767d\u5154 (Baumgartner \u7b49\u4eba\uff0c2016 \u5e74\uff09\uff0c\u4ee5\u53ca\u6700\u8fd1\u7684 ApoE&nbsp;<sup>-\/-<\/sup>\u5154\u5b50\uff08Niimi \u7b49\u4eba\uff0c2016 \u5e74\uff09\u3002<\/p>\n\n\n\n<p id=\"p0300\">\u5154\u5b50\u7684\u8102\u86cb\u767d\u4ee3\u8c22\u4e0e\u4eba\u7c7b\u76f8\u4f3c\uff08\u9664\u4e86\u809d\u8102\u80aa\u9176\u7f3a\u4e4f\uff09\uff0c\u5e76\u4e14\u4e0e\u5c0f\u9f20\u6709\u663e\u7740\u5dee\u5f02\u3002\u4e0eHDL\u662f\u4e3b\u8981\u8840\u6d46\u8102\u86cb\u767d\u7684\u5c0f\u9f20\u4e0d\u540c\uff0c\u5154\u5b50\u901a\u8fc7\u542b\u6709 ApoB \u7684\u9897\u7c92\uff08VLDL \u548c LDL\uff09\u8fd0\u8f93\u5927\u91cf\u80c6\u56fa\u9187\uff08&nbsp;Fan \u548c Watanabe\uff0c2000 \u5e74\uff09\u3002\u56e0\u6b64\uff0c\u5154\u5b50\u6709\u52a9\u4e8e\u6307\u51fa\u5347\u9ad8\u7684\u8840\u6d46\u80c6\u56fa\u9187\u4f5c\u4e3a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8d77\u59cb\u7684\u5173\u952e\u56e0\u7d20\u7684\u4f5c\u7528\u3002\u5154\u6a21\u578b\u7684\u5c40\u9650\u6027\u5305\u62ec\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u53d1\u5c55\u6240\u9700\u7684\u9ad8\u5ea6\u5f02\u5e38\u996e\u98df\u3001\u5927\u91cf\u708e\u75c7\u548c\u7531\u4e8e\u957f\u671f\u9ad8\u80c6\u56fa\u9187\u5582\u517b\u5bfc\u81f4\u7684\u809d\u6bd2\u6027\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sect0065\">4.1&nbsp;.&nbsp;Watanabe \u9057\u4f20\u6027\u9ad8\u8102\u8840\u75c7 (WHHL) \u5154<\/h3>\n\n\n\n<p id=\"p0305\">WHHL \u5154\u662f\u4e00\u79cd\u7a81\u53d8\u682a\uff0c\u7531\u4e8eLDL \u53d7\u4f53\u7f3a\u9677\u800c\u8868\u73b0\u51fa\u81ea\u53d1\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u548c\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff08Watanabe\uff0c1980\uff09\u3002\u5582\u98df\u6b63\u5e38\u996e\u98df\u7684\u7eaf\u5408 WHHL \u5154\u4ece\u51fa\u751f\u5c31\u5177\u6709\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff0c\u5176\u4e2d LDL \u662f\u4e3b\u8981\u7684\u8102\u86cb\u767d\u3002\u5b83\u4eec\u8868\u73b0\u51fa\u5404\u79cd\u7c7b\u578b\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\uff0c\u4ece\u65e9\u671f\u8102\u80aa\u6761\u7eb9\u5230\u4e3b\u52a8\u8109\u3001\u51a0\u72b6\u52a8\u8109\u548c\u5927\u8111\u52a8\u8109\u7684\u665a\u671f\u75c5\u53d8\uff08Atkinson \u7b49\u4eba\uff0c1989 \u5e74\uff0cBaumgartner \u7b49\u4eba\uff0c2016 \u5e74\uff09\u3002\u8fd9\u4e9b\u5154\u5b50\u4e5f\u663e\u793a\u51fa\u5fc3\u808c\u6897\u6b7b\u7684\u98ce\u9669\u589e\u52a0\u3002WHHL\u5154\u662f\u6700\u65e9\u7814\u7a76\u4ed6\u6c40\u7c7b\u836f\u7269\u6291\u5236\u6591\u5757\u4e0d\u7a33\u5b9a\u548c\u964d\u4f4e\u8840\u6813\u5f62\u6210\u6027\u7684\u5bb6\u5154\u6a21\u578b\u4e4b\u4e00\u3002<a href=\"http:\/\/www.shuyudiet.com\/?s=%E9%AB%98%E6%9E%9C%E7%B3%96\">\u9ad8\u679c\u7cd6<\/a>\u548c\u9ad8\u8102\u80aa\u996e\u98df\u5582\u517b\u7684WHHL\u5154\u51fa\u73b0\u65e9\u671f\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u8461\u8404\u7cd6\u8010\u91cf\uff0c\u5e76\u8868\u73b0\u51fa\u5177\u6709\u8102\u8d28\u6838\u5fc3\u548c\u9499\u5316\u7684\u4e3b\u52a8\u8109\u75c5\u53d8\u3002\u8be5\u6a21\u578b\u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u7814\u7a76\u80f0\u5c9b\u7d20\u62b5\u6297\u5bf9\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\u5f62\u6210\u7684\u5f71\u54cd\uff08Ning \u7b49\u4eba\uff0c2015 \u5e74\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sect0070\">4.2&nbsp;.&nbsp;\u65b0\u897f\u5170\u767d (NZW) \u5154<\/h3>\n\n\n\n<p id=\"p0310\">NZW\u5154\u901a\u5e38\u7528\u4e8e\u7814\u7a76\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3002\u5582\u98df\u6b63\u5e38\u996e\u98df\u7684 NZW \u5154\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u8f83\u4f4e\uff08\u5927\u591a &lt;50&nbsp;&nbsp;mg\/dl\uff09\uff0c\u56e0\u6b64\u4e0d\u4f1a\u53d1\u751f\u81ea\u53d1\u6027\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3002\u7136\u800c\uff0c\u5728\u996e\u98df\u4e2d\u6dfb\u52a0 0.3-0.5% \u7684\u80c6\u56fa\u9187\u4f1a\u4f7f\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u63d0\u9ad8\u5230 1000&nbsp;&nbsp;mg\/dl\u3002\u6591\u5757\u7684\u7ec4\u6210\u53d6\u51b3\u4e8e\u81b3\u98df\u80c6\u56fa\u9187\u7684\u6c34\u5e73\u548c\u80c6\u56fa\u9187\u5582\u517b\u7684\u6301\u7eed\u65f6\u95f4\u3002\u5176\u4e2d\u4e00\u79cd\u65b9\u6848\u662f\u8ba9\u6210\u5e74\u5154\u5b50\u5582\u98df\u5bcc\u542b\u80c6\u56fa\u9187\u7684\u996e\u98df\uff081.0-1.5%\u7684\u80c6\u56fa\u9187\uff09\u5f88\u77ed\u7684\u65f6\u95f4\uff08\u7ea68\u5468\uff09\u3002\u901a\u8fc7\u4f7f\u7528\u8fd9\u79cd\u996e\u98df\uff0c\u5154\u5b50\u60a3\u4e0a\u4e86\u4e25\u91cd\u7684\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff0c\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u57281500 \u2013 3000\u6beb\u514b\/\u5206\u5347\u4e4b\u95f4\uff0c\u8fd9\u5728\u4eba\u7c7b\u4e2d\u4ece\u672a\u89c1\u8fc7\uff0c\u5bfc\u81f4\u4e3b\u8981\u7531\u5de8\u566c\u7ec6\u80de\u6765\u6e90\u7684\u6ce1\u6cab\u7ec6\u80de\u7ec4\u6210\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u3002\u51fa\u4e8e\u8fd9\u4e2a\u539f\u56e0\uff0c\u6700\u5e38\u7528\u7684\u65b9\u6848\u662f\u4f7f\u7528\u542b\u6709 0.3% \u80c6\u56fa\u9187\u7684\u996e\u98df\uff0c\u8fdb\u884c\u6301\u7eed 20-26 \u5468\u7684\u5efa\u6a21\u3002\u5c31\u8be5\u79cd\u65b9\u6cd5\u5e73\u5747\u8ba1\u7b97\uff0c\u80c6\u56fa\u9187\u6c34\u5e73\u4e0a\u5347\u81f3\u7ea6 800&nbsp;&nbsp;mg\/dl\u3002\u8be5\u65b9\u6848\u5728\u4e3b\u52a8\u8109\u5f13\u548c\u80f8\u4e3b\u52a8\u8109\u4e2d\u5f62\u6210\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\uff0c\u800c\u4e0d\u662f\u5728\u8179\u4e3b\u52a8\u8109\uff08\u6591\u5757\u5f62\u6210\u4e0d\u592a\u660e\u663e\uff09\uff08&nbsp;Baumgartner \u7b49\u4eba\uff0c2016 \u5e74\uff0c&nbsp;Fan \u548c Watanabe\uff0c2000 \u5e74\uff09\uff0c\u800c\u5728\u4eba\u7c7b\u4e2d\uff0c\u6591\u5757\u901a\u5e38\u5728\u8179\u4e3b\u52a8\u8109\u3002\u51a0\u72b6\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5728\u80c6\u56fa\u9187\u5582\u517b\u7684\u5154\u5b50\u4e2d\u4e5f\u89c2\u5bdf\u5230\uff0c\u4f46\u901a\u5e38\u4ec5\u9650\u4e8e\u5de6\u51a0\u72b6\u52a8\u8109\u5e72\u3002\u6839\u636e\u80c6\u56fa\u9187\u5582\u517b\u7684\u65f6\u95f4\u957f\u77ed\uff0c\u4e5f\u4f1a\u53d1\u751f\u6591\u5757\u9499\u5316\u3002\u7136\u800c\uff0c\u6ca1\u6709\u8bc1\u636e\u8868\u660e\u81ea\u53d1\u6027\u6591\u5757\u7834\u88c2\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sect0075\">4.3&nbsp;.&nbsp;\u8f7d\u8102\u86cb\u767d E \u6572\u9664 (ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;) \u5154<\/h3>\n\n\n\n<p id=\"p0315\">\u6700\u8fd1\uff0cApoE&nbsp;<sup>-\/-<\/sup>\u5154\u88ab\u62a5\u9053\u4f5c\u4e3a\u7814\u7a76\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4e0e\u4eba\u7c7b\u9ad8\u8102\u8840\u75c7\u4e4b\u95f4\u5173\u7cfb\u7684\u6a21\u578b\uff08Niimi et al., 2016\uff09\u3002\u53ef\u4ee5\u4f7f\u7528\u57fa\u56e0\u7ec4\u7f16\u8f91\u9176\u751f\u6210ApoE&nbsp;<sup>-\/-<\/sup>\u5154\uff0c\u4f8b\u5982\u950c\u6307\u6838\u9178\u9176\u3001\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b50\u6837\u6548\u5e94\u6838\u9178\u9176 (TALEN) \u6216 RNA \u5f15\u5bfc\u7684 CRISPR \u76f8\u5173\u86cb\u767d 9 (Cas9)\u6838\u9178\u5185\u5207\u9176\u3002\u56e0\u4e3a\u5154\u5b50\u7684\u8102\u86cb\u767d\u8c31\u4e0e\u4eba\u7c7b\u76f8\u4f3c(Brousseau and Hoeg, 1999)\uff0c ApoE-\/-\u5154\u662fApoE-\/-\u5c0f\u9f20\u7684\u4e00\u4e2a\u6709\u5438\u5f15\u529b\u7684\u66ff\u4ee3\u54c1\u3002\u5373\u4f7f\u5728\u6b63\u5e38\u996e\u98df\u4e2d\uff0cApoE&nbsp;<sup>-\/-<\/sup><a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/zinc-finger-nuclease\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/endonuclease\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib12\"><\/a>\u5154\u5b50\u8868\u73b0\u51fa\u8f7b\u5ea6\u9ad8\u8102\u8840\u75c7\uff0c\u8840\u6d46\u603b\u80c6\u56fa\u9187\u6c34\u5e73\u7ea6\u4e3a 200&nbsp;mg\/dl\u3002\u7136\u800c\uff0c\u5f53\u5582\u98df\u5bcc\u542b\u80c6\u56fa\u9187\u7684\u996e\u98df\uff080.3% \u80c6\u56fa\u9187\u548c 3%\u5927\u8c46\u6cb9\uff0c\u6301\u7eed 2 \u5468\uff09\u65f6\uff0c\u5b83\u4eec\u7684\u8840\u6d46\u603b\u80c6\u56fa\u9187\u6c34\u5e73\u4f1a\u589e\u52a0\u5230\u7ea6 1000&nbsp;mg\/dl\uff08\u800c\u5582\u98df\u80c6\u56fa\u9187\u7684\u91ce\u751f\u578b\u5154\u5b50\u7ea6\u4e3a 170 mg\/dl&nbsp;\uff09\u3002\u5f53\u5582\u98df\u80c6\u56fa\u9187\u996e\u98df 10 \u5468\u65f6\uff0c\u4e0e\u91ce\u751f\u578b\u5154\u76f8\u6bd4\uff0c&nbsp;ApoE&nbsp;<sup>-\/-<\/sup>\u5154\u51fa\u73b0\u66f4\u660e\u663e\u7684\u4e3b\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff08 Niimi \u7b49\u4eba\uff0c2016 \u5e74\uff09\u3002\u56e0\u4e3a ApoE \u548c LDL \u53d7\u4f53\u90fd\u5728\u4ecb\u5bfc\u80c6\u56fa\u9187\u4ee3\u8c22\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u6240\u4ee5 ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/soybean-oil\"><\/a>&nbsp;&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/aortic-atherosclerosis\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299917303205?via%3Dihub#bib68\"><\/a>\u5bb6\u5154\u548c LDL \u53d7\u4f53\u7f3a\u9677\u578b WHHL \u5bb6\u5154\u53ef\u80fd\u662f\u7814\u7a76\u4eba\u7c7b\u9ad8\u8102\u8840\u75c7\u7684\u6709\u4ef7\u503c\u6a21\u578b\uff1aApoE&nbsp;<sup>-\/-<\/sup>\u5bb6\u5154\u663e\u793a\u6b8b\u4f59\u8102\u86cb\u767d\u5347\u9ad8\uff0c\u800c WHHL \u5bb6\u5154\u5177\u6709\u9ad8\u6c34\u5e73\u7684 LDL \u4f34\u968f\u7740\u4f4e HDL (&nbsp;Niimi et al., 2016)\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sect0080\">5&nbsp;.&nbsp;\u5927\u578b\u52a8\u7269\u6a21\u578b\uff08\u732a\u548c\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\uff09<\/h2>\n\n\n\n<p id=\"p0320\">\u5c3d\u7ba1\u5c0f\u52a8\u7269\u6a21\u578b\u63d0\u4f9b\u4e86\u5bf9\u52a8\u8109\u7ca5\u6837\u786c\u5316\u9a71\u52a8\u673a\u5236\u7684\u6df1\u5165\u4e86\u89e3\uff0c\u4f46\u4ecd\u9700\u8981\u989d\u5916\u7684\u7b56\u7565\u5c06\u8fd9\u4e9b\u53d1\u73b0\u8f6c\u5316\u4e3a\u5bf9\u4eba\u7c7b\u75c7\u72b6\u6027\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u9884\u9632\u548c\u6cbb\u7597\u3002\u9ad8\u6548\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5927\u578b\u52a8\u7269\u6a21\u578b\u53ef\u80fd\u6709\u52a9\u4e8e\u5e94\u5bf9\u8fd9\u4e9b\u6311\u6218\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5c06\u4ece\u5c0f\u9f20\u7814\u7a76\u4e2d\u83b7\u5f97\u7684\u77e5\u8bc6\u8f6c\u5316\u4e3a\u4eba\u7c7b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u836f\u7269\u7684\u5f00\u53d1\u53ef\u4ee5\u53d7\u76ca\u4e8e\u4e00\u79cd\u6865\u63a5\u5de5\u5177\uff0c\u4f8b\u5982\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u732a\u6a21\u578b\u3002\u4e0d\u4ec5\u53ef\u4ee5\u5728\u6b64\u7c7b\u6a21\u578b\u4e2d\u7814\u7a76\u836f\u7269\u6cbb\u7597\u5bf9\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5f71\u54cd\uff0c\u8fd8\u53ef\u4ee5\u8bc4\u4f30\u4e34\u5e8a\u6210\u50cf\u7ec8\u70b9\u4f5c\u4e3a\u540e\u7eed II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6307\u5bfc\u5de5\u5177 (&nbsp;Shim et al., 2016\uff09\u3002\u5927\u578b\u52a8\u7269\u7684\u57fa\u56e0\u7f16\u8f91\u5de5\u5177\u4f7f\u5f97\u521b\u9020\u57fa\u56e0\u4fee\u9970\u7684\u5c0f\u578b\u732a\u6210\u4e3a\u53ef\u80fd\uff0c\u8fd9\u4e9b\u5c0f\u578b\u732a\u5728\u75c5\u53d8\u90e8\u4f4d\u548c\u7ec4\u7ec7\u75c5\u7406\u5b66\u7684\u504f\u597d\u65b9\u9762\u4e0e\u4eba\u7c7b\u6709\u8bb8\u591a\u76f8\u4f3c\u4e4b\u5904\u3002\u4f8b\u5982\uff0c\u5177\u6709\u4eba\u7c7b D374Y-PCSK9 \u809d\u810f\u7279\u5f02\u6027\u8868\u8fbe\u7684\u5c0f\u578b\u732a\u8868\u73b0\u51fa\u4e25\u91cd\u7684\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u548c\u8fdb\u884c\u6027\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75c5\u53d8\u7684\u53d1\u5c55\uff08&nbsp;Al-Mashhadi \u7b49\u4eba\uff0c2013 \u5e74\uff09\u3002\u4e0e\u73b0\u6709\u7684\u57fa\u4e8e\u81ea\u53d1\u7a81\u53d8\u6216\u4e25\u91cd\u7cd6\u5c3f\u75c5\u7684\u732a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6a21\u578b\u4e00\u8d77\uff0c\u8fd9\u4e9b\u6a21\u578b\u53ef\u80fd\u4e3a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u8f6c\u5316\u7814\u7a76\u63d0\u4f9b\u65b0\u7684\u65b9\u6cd5\uff08&nbsp;Shim et al., 2016\uff09\u3002<\/p>\n\n\n\n<p id=\"p0325\">\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u5728\u5582\u98df\u9ad8\u8102\u80aa\/\u9ad8\u80c6\u56fa\u9187\u996e\u98df\u65f6\u4f1a\u8868\u73b0\u51fa\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff0c\u5e76\u4f1a\u51fa\u73b0\u4e0e\u4eba\u7c7b\u76f8\u4f3c\u7684\u51a0\u72b6\u52a8\u8109\u7ea4\u7ef4\u8102\u80aa\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\uff08Getz \u548c Reardon\uff0c2012 \u5e74\uff09\u3002\u7136\u800c\uff0c\u4f7f\u7528\u5b9e\u9a8c\u7334\u8fdb\u884c\u5efa\u6a21\u662f\u975e\u5e38\u6602\u8d35\u7684\uff0c\u4e5f\u4f1a\u53d7\u5230\u9ad8\u5ea6\u76d1\u7ba1\uff0c\u5e76\u4e14\u9700\u8981\u975e\u5e38\u4e13\u4e1a\u7684\u5b9e\u9a8c\u52a8\u7269\u79d1\u5b66\u6280\u80fd\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u6a21\u578b\u5e76\u4e0d\u7ecf\u5e38\u4f7f\u7528\u3002\u7136\u800c\uff0c\u51e0\u5e74\u524d\uff0c\u4e5f\u6709\u4eba\u53d1\u660e\u4e86\u6572\u9664\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\uff0c\u8fd9\u53ef\u80fd\u4f1a\u52a0\u5f3a\u4eba\u4eec\u5bf9\u52a0\u901f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5927\u578b\u52a8\u7269\u6a21\u578b\u7684\u5174\u8da3\uff08Niu \u7b49\u4eba\uff0c2014 \u5e74\uff0cShim \u7b49\u4eba\uff0c2016 \u5e74\uff09\u3002<\/p>\n\n\n\n<p id=\"p0330\">\u603b\u4e4b\uff0c\u5168\u4e16\u754c\u7684\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u505a\u51fa\u4e86\u8bb8\u591a\u52aa\u529b\u6765\u5f00\u53d1\u5c3d\u53ef\u80fd\u597d\u5730\u7c7b\u4f3c\u4e8e\u4eba\u7c7b\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u52a8\u7269\u6a21\u578b\u3002\u7136\u800c\uff0c\u76ee\u524d\u7684\u6bcf\u79cd\u52a8\u7269\u6a21\u578b\u90fd\u6709\u5176\u4f18\u70b9\u548c\u5c40\u9650\u6027\uff0c\u5982\u8868 2 \u6240\u793a\u3002\u5f53\u4e0b\uff0c\u5f00\u53d1\u4e00\u79cd\u81ea\u53d1\uff08\u5373\u6ca1\u6709\u673a\u68b0\u5e72\u9884\uff09\u6591\u5757\u7834\u88c2\u7684\u52a8\u7269\u6a21\u578b\u662f\u4e00\u4e2a\u5177\u6709\u975e\u5e38\u5927\u6311\u6218\u7684\u4e8b\u60c5\uff0c\u6211\u4eec\u5e0c\u671b\u8be5\u6a21\u578b\u5177\u6709\u7c7b\u4f3c\u4eba\u7c7b\u7684\u7684\u75c5\u53d8\u665a\u671f\u75c7\u72b6\uff0c\u4f8b\u5982\u5fc3\u808c\u6897\u6b7b\u3001\u4e2d\u98ce\u548c\u731d\u6b7b\u3002\u8fd9\u4e9b\u7279\u5f81\u5b58\u5728\u4e8e ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u4e2d\uff0c\u4f7f\u5176\u6210\u4e3a\u8bc4\u4f30\u6f5c\u5728\u6591\u5757\u7a33\u5b9a\u7597\u6cd5\u7684\u6709\u524d\u666f\u7684\u6a21\u578b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td>\u7a7a\u5355\u5143\u683c<\/td><th><strong>\u597d\u5904<\/strong><\/th><th><strong>\u9650\u5236<\/strong><\/th><\/tr><\/thead><tbody><tr><th><strong>\u8001\u9f20<\/strong><\/th><td>\u2022\u76f8\u5bf9\u4fbf\u5b9c\u2022\u9ad8\u6548\u7684\u2022\u5bb9\u6613\u6742\u4ea4\u2022\u836f\u7269\u5e72\u9884\u7814\u7a76\u6210\u672c\u4f4e<\/td><td>\u2022\u4e0e\u4eba\u7c7b\u6591\u5757\u7684\u533a\u522b\uff1a\u8f83\u5c11\u7684\u51a0\u72b6\u52a8\u8109\u6591\u5757\u5f62\u6210\u2013\u65e0\u6591\u5757\u5185\u65b0\u751f\u8840\u7ba1\u548c\u51fa\u8840\u2013\u7f55\u89c1\u7684\u6591\u5757\u7834\u88c2\u548c\u8840\u6813\u5f62\u6210\uff0c\u7136\u800c\uff0c\u8fd9\u4e9b\u9650\u5236\u5728 ApoE&nbsp;<sup>-\/-<\/sup>&nbsp;Fbn1&nbsp;<sup>C1039G+\/-<\/sup>\u5c0f\u9f20\u4e2d\u5f97\u5230\u4e86\u514b\u670d\u3002<\/td><\/tr><tr><th><strong>\u5154\u5b50<\/strong><\/th><td>\u2022\u5141\u8bb8\u8f6c\u8bd1\u7814\u7a76\uff0c\u4f8b\u5982\u4e3b\u52a8\u8109\u5bfc\u7ba1\u63d2\u5165\u672f\uff08\u51a0\u72b6\u52a8\u8109\u592a\u5c0f\uff09\u2022\u76f8\u5bf9\u4fbf\u5b9c\u2022\u6613\u4e8e\u7e41\u6b96\u548c\u5904\u7406<\/td><td>\u2022\u4e0e\u4eba\u7c7b\u76f8\u6bd4\uff0c\u6591\u5757\u5b9a\u4f4d\u7684\u5dee\u5f02\uff1a\u2013\u6591\u5757\u5728\u4e3b\u52a8\u8109\u5f13\u548c\u964d\u4e3b\u52a8\u8109\u4e2d\u6700\u4e3a\u660e\u663e\uff08\u4e0e\u4eba\u7c7b\u7684\u8179\u4e3b\u52a8\u8109\u76f8\u53cd\uff09<\/td><\/tr><tr><th><strong>\u732a<\/strong><\/th><td>\u2022\u4e0e\u4eba\u7c7b\u6591\u5757\u7684\u76f8\u4f3c\u4e4b\u5904\uff1a\u2013\u5b9a\u4f4d\uff1a\u51a0\u72b6\u52a8\u8109\u3001\u8179\u4e3b\u52a8\u8109\u3001\u56de\u80a1\u52a8\u8109\u2013\u671d\u5411\u6591\u5757\u7684\u65b0\u751f\u8840\u7ba1\u5f62\u6210<\/td><td>\u2022\u6591\u5757\u53d1\u80b2\u4e3b\u8981\u5728\u6ce1\u6cab\u7ec6\u80de\u9636\u6bb5\u7ed3\u675f\uff08\u8fd9\u53ef\u4ee5\u901a\u8fc7\u9009\u62e9\u5929\u7136\u7a81\u53d8\u4f53\u3001\u673a\u68b0\u635f\u4f24\u3001\u5f15\u5165\u5176\u4ed6\u98ce\u9669\u56e0\u7d20\u3001\u5c0f\u578b\u732a\u57fa\u56e0\u5de5\u7a0b\u6765\u514b\u670d\uff09\u2022\u6591\u5757\u7834\u88c2\u5bfc\u81f4\u7684\u8840\u6813\u5f62\u6210\u5f88\u5c11\u89c1\uff08\u4e0e\u4eba\u7c7b\u76f8\u6bd4\uff09\u2022\u76f8\u5bf9\u6602\u8d35\u4e14\u66f4\u96be\u5904\u7406<\/td><\/tr><tr><th><strong>\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269<\/strong><\/th><td>\u2022\u4e0e\u4eba\u7c7b\u76f8\u6bd4\uff0c\u6591\u5757\u5f62\u6210\u975e\u5e38\u76f8\u4f3c\uff08\u5fae\u89c2\u548c\u5b8f\u89c2\uff09\u2022\u51a0\u72b6\u52a8\u8109\u6591\u5757\u5f62\u6210<\/td><td>\u2022\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u4ef7\u683c\u6602\u8d35\u4e14\u53d7\u5230\u4e25\u683c\u76d1\u7ba1\u2022\u9700\u8981\u4e13\u95e8\u7684\u57f9\u8bad<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u663e\u793a\u8be6\u7ec6\u4fe1\u606f<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u539f\u6587\u4e0b\u8f7d<\/h2>\n\n\n\n<p><a href=\"http:\/\/www.shuyudiet.com\/download\/492\/?tmstv=1750186151\">Animal models of atherosclerosis (2651 downloads )<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u8981 \u7406\u60f3\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u52a8\u7269\u6a21\u578b\uff0c\u5e94\u8be5\u662f\u5177\u6709\u7c7b\u4f3c\u4e8e\u4eba\u4f53\u89e3\u5256\u5b66\u548c\u75c5\u7406\u751f\u7406\u5b66\u7684\u75c5\u53d8\u72b6\u6001\uff0c\u5e76\u6709\u53ef\u80fd\u7528\u4e8e\u533b\u5b66\u548c\u836f\u7269\u7814\u7a76 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":174,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[30,134],"class_list":["post-176","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","tag-as","tag-134"],"_links":{"self":[{"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=\/wp\/v2\/posts\/176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=176"}],"version-history":[{"count":1,"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=\/wp\/v2\/posts\/176\/revisions"}],"predecessor-version":[{"id":177,"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=\/wp\/v2\/posts\/176\/revisions\/177"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=\/wp\/v2\/media\/174"}],"wp:attachment":[{"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=176"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.leishidiet.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}