{"id":169,"date":"2025-06-18T02:37:03","date_gmt":"2025-06-17T18:37:03","guid":{"rendered":"http:\/\/www.leishidiet.com\/?p=169"},"modified":"2025-06-19T02:52:47","modified_gmt":"2025-06-18T18:52:47","slug":"%e4%b8%8d%e5%90%8c%e5%93%81%e7%b3%bb%e5%b0%8f%e9%bc%a0%e8%83%86%e7%bb%93%e7%9f%b3%e9%80%a0%e6%a8%a1%e7%9a%84%e5%b7%ae%e5%bc%82","status":"publish","type":"post","link":"https:\/\/www.leishidiet.com\/?p=169","title":{"rendered":"\u4e0d\u540c\u54c1\u7cfb\u5c0f\u9f20\u80c6\u7ed3\u77f3\u9020\u6a21\u7684\u5dee\u5f02"},"content":{"rendered":"\n

\u5c0f\u9f20\u56e0\u4e3a\u5176\u5e9e\u5927\u7684\u4fdd\u6709\u91cf\uff0c\u65b9\u4fbf\u83b7\u53d6\uff0c\u662f\u826f\u597d\u7684\u80c6\u7ed3\u77f3\u9020\u6a21<\/a>\u5b9e\u9a8c\u52a8\u7269\u4e4b\u4e00\u3002Fujihira\u7b49\u7814\u7a76\u8005\u7ed9\u516b\u79cd\u8fd1\u4ea4\u7cfb\u5c0f\u9f20\u9972\u5582\u81f4\u77f3\u9972\u659910\u5468\u540e\u89c2\u5bdf\u5230\u5c0f\u9f20\u51fa\u73b0\u80c6\u7ed3\u77f3\uff0c\u60a3\u75c5\u7387\u4ece0%~100%\u4e0d\u7b49\uff1bAlexander\u3001Portman\u3001wang\u7b49\u4eba\u7684\u7814\u7a76\u8fdb\u4e00\u6b65\u786e\u8ba4\u4e86\u5c0f\u9f20\u5728\u81f4\u77f3\u9972\u6599\u7684\u5582\u517b\u4e0b\uff0c\u80c6\u7ed3\u77f3\u60a3\u75c5\u7387\u5b58\u5728\u54c1\u7cfb\u548c\u6027\u522b\u5dee\u5f02\uff1bMatsumoto\u7b49\u7814\u7a76\u8005\u53d1\u73b0\u57fa\u56e0\u7f16\u8f91\u5c0f\u9f20\u5728\u81f4\u77f3\u9972\u6599\u7684\u77ed\u671f\u5582\u517b\u4e0b\u5f88\u5feb\u5c31\u51fa\u73b0\u4e86\u80c6\u7ed3\u77f3\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cC57BL\/6\u54c1\u7cfb\u5c0f\u9f20\u6700\u9002\u5408\u7528\u4e8e\u80c6\u7ed3\u77f3\u9020\u6a21\uff0c\u5bf9\u80c6\u56fa\u9187\u76f8\u5bf9\u6bd4\u8f83\u654f\u611f\uff0c\u5728\u996e\u98df\u8bf1\u5bfc\u7684\u6761\u4ef6\u4e0b\u6210\u77f3\u65f6\u95f4\u8f83\u5feb\uff0c\u7279\u522b\u662f\u5728\u4f34\u968f\u4e00\u4e9b\u8c03\u63a7\u57fa\u56e0\u7f3a\u5931\u65f6\uff0c\u4f1a\u66f4\u5feb\u7684\u6210\u6a21\uff0c\u8fd9\u4e9b\u7814\u7a76\u5206\u6790\u4e3a\u5c0f\u9f20\u80c6\u7ed3\u77f3\u9020\u6a21\u7814\u7a76\u6253\u4e0b\u4e86\u826f\u597d\u57fa\u7840\uff08\u89c1\u88681\u6240\u793a\uff09\u3002<\/p>\n\n\n\n

\u88681<\/strong>  \u4e0d\u540c\u54c1\u7cfb\u3001\u6027\u522b\u3001\u5904\u7406\u7684\u5c0f\u9f20\u80c6\u7ed3\u77f3\u9020\u6a21\u7814\u7a76<\/a><\/p>\n\n\n\n

Table<\/strong> 1<\/strong>  Study on gallstone model of mice with different strains, genders and treatments<\/p>\n\n\n\n

 <\/td>\u5c0f\u9f20\u54c1\u7cfb Strains\/genders<\/td>\u9020\u6a21\u65f6\u95f4Timeconsuming<\/td>\u6210\u6a21\u7ed3\u679cStudy result<\/td><\/tr>
Fujihira, et al.<\/td> C57BL\/6\u3001NC\u3001DBA\u3001C3H\u3001BALB\/C\u30019BL -at\u3001KK\u3001C57BL\/6-db\/db<\/td>10\u5468(wk)<\/td>\u654f\u611f\uff1aC57BL\/6\u3001NC\uff1b\u4e0d\u654f\u611f\uff1aKK\u3001C57BL\/6-db\/db
Sensitive strains:C57BL\/6\u3001NCNon-sensitive strains: KK\u3001C57BL\/6-db\/db<\/td><\/tr>
Alexander, Portman, et al.<\/td>\u96cc\u6027CBA\/J(Female)\u3001\u96c4\u6027CBA\/J(Male)\u3001\u96cc\u6027C57BL6J(Female)\u3001\u96c4\u6027C57BL6J(Male)<\/td>2\u5468(wk)<\/td>\u7ed3\u77f3\u7387\uff1a\u96c4\u6027C57BL6J\u4e3a48.9%\uff1b\u96cc\u6027C57BL6J\u4e3a2.7%\uff1bCBA\/J\u4e3a0
Gallstones percent: C57BL6J(Male)48.9%,C57BL6J(Female)2.7%,CBA\/J 0%<\/td><\/tr>
Wang, et al.<\/td>\u96cc\u6027C57L\u3001AKR\u3001C57L\u00d7AKR(Female)<\/td>8\u5468(wk)<\/td>\u654f\u611f\uff1aC57L\uff1b\u4e2d\u5ea6\u654f\u611f\uff1aC57L\u00d7AKR\uff1b\u4e0d\u654f\u611f\uff1aAKR
Sensitive strains:C57L\u3001Medium sensitive:C57L\u00d7AKR\u3001Non-sensitive strains: AKR<\/td><\/tr>
Histochemica, et al.<\/td> \u96c4\u6027C57BL(Male)\u3001\u96cc\u6027C57BL(Female)<\/td>8\u5468(wk)<\/td>\u96c4\u6027C57BL6J\u89c2\u5bdf\u5230\u7ed3\u77f3
Gallstones Observed on C57BL(Male)<\/td><\/tr>
Matsumoto, et al.<\/td>Cldn2\u57fa\u56e0\u6572\u9664C57BL\/6J(Cldn2 gene knockout) <\/td>4\u5468(wk)<\/td>\u6210\u77f3\u7387\uff1a100%
Gallstones percent\uff1a100%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u663e\u793a\u8be6\u7ec6\u4fe1\u606f<\/p>\n\n\n\n

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